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SHISA2 shisa family member 2 [ Homo sapiens (human) ]

Gene ID: 387914, updated on 26-May-2016
Official Symbol
SHISA2provided by HGNC
Official Full Name
shisa family member 2provided by HGNC
Primary source
HGNC:HGNC:20366
See related
Ensembl:ENSG00000180730 HPRD:16589; Vega:OTTHUMG00000016612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM46; hShisa; C13orf13; PRO28631; WGAR9166; bA398O19.2
Orthologs
Location:
13q12.13
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (26044597..26059587, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (26618735..26625198, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8A2 Neighboring gene uncharacterized LOC105370122 Neighboring gene RNA, Ro-associated Y1 pseudogene 3 Neighboring gene ATPase phospholipid transporting 8A2 pseudogene 3 Neighboring gene prune exopolyphosphatase pseudogene 1 Neighboring gene ring finger protein 6

Replication interactions

Interaction Pubs
Knockdown of shisa homolog 2 (SHISA2; TMEM46) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein shisa-2 homolog
Names
shisa homolog 2
transmembrane protein 46

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007538.1NP_001007539.1  protein shisa-2 homolog precursor

    See identical proteins and their annotated locations for NP_001007539.1

    Status: VALIDATED

    Source sequence(s)
    AL139004
    Consensus CDS
    CCDS31951.1
    UniProtKB/Swiss-Prot
    Q6UWI4
    Related
    ENSP00000313079, OTTHUMP00000018153, ENST00000319420, OTTHUMT00000044239
    Conserved Domains (1) summary
    pfam13908
    Location:34151
    Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

    Range
    26044597..26059587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535073.1XP_011533375.1  

    See identical proteins and their annotated locations for XP_011533375.1

  2. XM_011535072.1XP_011533374.1  

    See identical proteins and their annotated locations for XP_011533374.1

  3. XM_011535071.1XP_011533373.1  

    See identical proteins and their annotated locations for XP_011533373.1

  4. XM_011535074.1XP_011533376.1  

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    26586869..26593340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)