We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

KRT18 keratin 18 [ Homo sapiens (human) ]

Gene ID: 3875, updated on 16-May-2013

Summary

Go to the top of the page Help

Official Symbol: KRT18provided by HGNC
Official Full Name: keratin 18provided by HGNC
Primary source: HGNC:6430
Locus tag: PIG46
See related: Ensembl:ENSG00000111057; HPRD:01020; MIM:148070; Vega:OTTHUMG00000169882
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: K18; CYK18
Summary: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Genomic context

Go to the top of the page Help

Location :: 12q13

Sequence :: Chromosome: 12; NC_000012.11 (53342655..53346685)

See KRT18 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low Cytokeratin 18 expression is associated with less response to therapy in non-small-cell lung cancer.
Title: Can determination of circulating endothelial cells and serum caspase-cleaved CK18 predict for response and survival in patients with advanced non-small-cell lung cancer receiving endostatin and paclitaxel-carboplatin chemotherapy? a retrospective study.
There is aberrant expression of CK18 in dysplasia, oral submucous fibrosis, and oral squamous cell carcinoma, suggesting CK18 as a surrogate marker of malignant transformation.
Title: Increased expression of CK8 and CK18 in leukoplakia, oral submucous fibrosis, and oral squamous cell carcinoma: an immunohistochemistry study.
A key K8/K18 regulation of glucose metabolism in normal and cancerous hepatic cells through differential modulations of mitochondrial hexokinase status and insulin-mediated signaling.
Title: Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling.
H. pylori-mediated cleavage of CK18 appeared proportional to the number of CagA EPIYA-C and CM motifs, which seemed to be downplayed in the presence of EPIYA-B motifs
Title: A potential association between Helicobacter pylori CagA EPIYA and multimerization motifs with cytokeratin 18 cleavage rate during early apoptosis.
Keratin 18 increases CFTR expression by binding to its C-terminal hydrophobic domain.
Title: Keratin K18 increases cystic fibrosis transmembrane conductance regulator (CFTR) surface expression by binding to its C-terminal hydrophobic patch.
Elevated serum M30 and M65 is associated with treatment response in advanced gastric cancer.
Title: The prognostic significance of the increase in the serum M30 and M65 values after chemotherapy and relationship between these values and clinicopathological factors in patients with advanced gastric cancer.
Keratin filaments were assembled from recombinant keratin proteins 8 (K8) and 18 (K18) in the presence of divalent ions (Mg(2+)).
Title: Properties of intermediate filament networks assembled from keratin 8 and 18 in the presence of Mg²+.
loss of cytokeratin 18 expression might be a good indicator of the poor prognosis of the breast cancer and it may play an active role in the breast tumorigenesis.
Title: The prognostic potential of keratin 18 in breast cancer associated with tumor dedifferentiation, and the loss of estrogen and progesterone receptors.
There is a synergism between risky alcohol consumption and common metabolic disorders (particularly obesity) in relation to serum concentrations of cytokeratin-18.
Title: Synergistic effect of alcohol consumption and body mass on serum concentrations of cytokeratin-18.
In patients with hemochromatosis, intronic but not exonic K8/K18 variants associate with liver fibrosis development.
Title: Non-coding keratin variants associate with liver fibrosis progression in patients with hemochromatosis.

Submit: New GeneRIF Correction See all (85)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
NP_000215.1	NP_005179.2	CBL	BIND	PubMed	c-Cbl interacts with Keratin 18.
NP_000215.1	NP_003780.1	TRADD	BIND	PubMed	K18 interacts with TRADD.
P05783	Q9UQM7	CAMK2A	HPRD	PubMed
P05783	P42574	CASP3	HPRD	PubMed
P05783	P55212	CASP6	HPRD	PubMed
P05783	P55210	CASP7	HPRD	PubMed
P05783	Q14790	CASP8	HPRD	PubMed
P05783	P22681	CBL	HPRD	PubMed
P05783	Q15834	CCDC85B	HPRD	PubMed
P05783	P06493	CDK1	HPRD	PubMed
P05783	Q9UMD9	COL17A1	HPRD	PubMed
P05783	O75618	DEDD	HPRD	PubMed
P05783	O75190	DNAJB6	HPRD	PubMed
P05783	P00533	EGFR	HPRD	PubMed
P05783	Q8IYI6	EXOC8	HPRD	PubMed
P05783	O14964	HGS	HPRD	PubMed
P05783	Heat shock 70 KD protein 1A	HSPA1A	HPRD	PubMed
P05783	P11021	HSPA5	HPRD	PubMed
P05783	P19012	KRT15	HPRD	PubMed
P05783	P13647	KRT5	HPRD	PubMed
P05783	P05787	KRT8	HPRD	PubMed
P05783	O95751	LDOC1	HPRD	PubMed
P05783	Q16539	MAPK14	HPRD	PubMed
P05783	Q9Y5B8	NME7	HPRD	PubMed
P05783	P98161	PKD1	HPRD	PubMed
P05783	Q99959	PKP2	HPRD	PubMed
P05783	Q9H307	PNN	HPRD	PubMed
P05783	P17252	PRKCA	HPRD	PubMed
P05783	Q02156	PRKCE	HPRD	PubMed
P05783	P04049	RAF1	HPRD	PubMed
P05783	Q8IUC4	RHPN2	HPRD	PubMed
P05783	P51812	RPS6KA3	HPRD	PubMed
P05783	P05121	SERPINE1	HPRD	PubMed
P05783	P29353	SHC1	HPRD	PubMed
P05783	Trichoplein	TCHP	HPRD	PubMed
P05783	P20333	TNFRSF1B	HPRD	PubMed
P05783	Q15628	TRADD	HPRD	PubMed
P05783	P23258	TUBG1	HPRD	PubMed
P05783	Gamma tubulin ring complex protein	TUBGCP4	HPRD	PubMed
P05783	O75445	USH2A	HPRD	PubMed
P05783	P31946	YWHAB	HPRD	PubMed
P05783	P62258	YWHAE	HPRD	PubMed
P05783	P61981	YWHAG	HPRD	PubMed
P05783	Q04917	YWHAH	HPRD	PubMed
P05783	P63104	YWHAZ	HPRD	PubMed
BioGRID:110073	BioGRID:106739	ALK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:107776	ATF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:119650	C14orf166	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:119569	C22orf28	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:107315	CBL	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:116198	CCDC85B	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:116179	CCNI	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:107424	CDC5L	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:107434	CDH1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:112978	CLEC3B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:116660	CNOT1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:107704	COL17A1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110073	BioGRID:108019	DDX1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:114627	DEDD	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110073	BioGRID:115360	DNAJB6	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110073	BioGRID:108347	EP300	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:127206	EXOC8	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:108577	FKBP3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:108603	FLII	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:108621	FN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:115340	FRAT1	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:115154	GIT2	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:109153	GRN	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:114593	HGS	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:115530	HNRNPR	BioGRID	PubMed	Co-fractionation
BioGRID:110073	BioGRID:109433	HNRNPU	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:109501	HRAS	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:109540	HSPA4	BioGRID	PubMed	Reconstituted Complex
BioGRID:110073	BioGRID:114089	IKBKG	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110073	BioGRID:115015	IQCB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:109883	ITGA4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:110036	KPNA2	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:110064	KRT15	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:110050	KRT5	BioGRID	PubMed	Co-purification
BioGRID:110073	BioGRID:126715	KRT72	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:110054	KRT8	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:117169	LDOC1	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:110333	MCC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:118963	NME7	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:110906	NOS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:111043	ORC5	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:115017	PDE4DIP	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:119624	PIAS4	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:111327	PKD1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110073	BioGRID:111335	PKP2	BioGRID	PubMed	Reconstituted Complex
	NP_009114.1	PKP3	BIND	PubMed	PKP3 interacts with KRT18 (CK18)
BioGRID:110073	BioGRID:116357	PKP3	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:111412	PNN	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110073	BioGRID:117417	POT1	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:111490	PPM1B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:111567	PRKCE	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110073	BioGRID:117406	RCHY1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110073	BioGRID:111914	RFC2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:114507	RPL14	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:115247	SEC16A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:112486	SMARCD1	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:114397	SQSTM1	BioGRID	PubMed	Co-localization
BioGRID:110073	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110073	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110073	BioGRID:112496	SUMO3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110073	BioGRID:112707	SVIL	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:112987	TNFRSF1B	BioGRID	PubMed	Reconstituted Complex
BioGRID:110073	BioGRID:114257	TRADD	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110073	BioGRID:118078	TUBGCP4	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:117356	TXN2	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:119253	TXNDC11	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-localization
BioGRID:110073	BioGRID:124189	USP32	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:113255	VCAM1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110073	BioGRID:124871	YTHDC1	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:113364	YWHAG	BioGRID	PubMed	Two-hybrid
BioGRID:110073	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110073	BioGRID:113366	YWHAZ	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

Go to the top of the page Help

Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
Caspase cascade in apoptosis, organism-specific biosystem
Caspase cascade in apoptosis
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
Pathogenic Escherichia coli infection, organism-specific biosystemSources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG]
Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...

General gene information

Go to the top of the page Help

Markers

RH71455 (e-PCR)
- UniSTS:34821

PMC17321P1 (e-PCR)
- UniSTS:271636

STS-N95819 (e-PCR)
- UniSTS:81461

SHGC-11808 (e-PCR)
- UniSTS:27701

G66074 (e-PCR)
- UniSTS:230065

D12S764 (e-PCR)
- UniSTS:148915

G66248 (e-PCR)
- UniSTS:230089

Genotypes

See KRT18 SNP Geneview Report
See KRT18 SNP Genotype Report
See KRT18 SNP Variation Viewer Report

Homology

Homologs of the KRT18 gene: The KRT18 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and zebrafish.
Map Viewer (Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Golgi to plasma membrane CFTR protein transport	IDA Inferred from Direct Assay more info	PubMed
anatomical structure morphogenesis	TAS Traceable Author Statement more info	PubMed
apoptotic process	IEA Inferred from Electronic Annotation more info
cell cycle	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
virus-host interaction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
centriolar satellite	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info
intermediate filament	IDA Inferred from Direct Assay more info	PubMed
keratin filament	IDA Inferred from Direct Assay more info	PubMed
microtubule organizing center	IDA Inferred from Direct Assay more info	PubMed
nucleolus	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: keratin, type I cytoskeletal 18

Names: keratin, type I cytoskeletal 18; CK-18; keratin-18; cytokeratin 18; cytokeratin-18; cell proliferation-inducing protein 46; cell proliferation-inducing gene 46 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008351.1 RefSeqGene

Range

5001..9031

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000224.2 → NP_000215.1 keratin, type I cytoskeletal 18

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

BC000180, CD106591, X12881

Consensus CDS

CCDS31809.1

UniProtKB/Swiss-Prot

P05783

Related

ENSP00000373487, OTTHUMP00000242378, ENST00000388835, OTTHUMT00000406405

Conserved Domains (1) summary

pfam00038
Location:79 – 389
Blast Score: 926

Filament; Intermediate filament protein
NM_199187.1 → NP_954657.1 keratin, type I cytoskeletal 18

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

BC000180, BG753529, CD106591, X12881

Consensus CDS

CCDS31809.1

UniProtKB/Swiss-Prot

P05783

Related

ENSP00000373489, ENST00000388837

Conserved Domains (1) summary

pfam00038
Location:79 – 389
Blast Score: 926

Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p10 Primary Assembly

Range

53342655..53346685

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

50386471..50390501

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018923.1 Alternate CHM1_1.0

Range

53176708..53180739

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01008301.1 (8452..12482)	None
genomic	AC107016.20 (18688..22718)	None
genomic	AF179904.1	AAA59461.1
genomic	AMYH01004475.1 (44754..48785)	None
genomic	CH471054.1	EAW96655.1
		EAW96656.1
genomic	HC921479.1	CBU83085.1
genomic	HD063881.1	CBU30436.1
mRNA	AK129587.1	None
mRNA	AK223093.1	BAD96813.1
mRNA	AK308506.1	None
mRNA	AK313988.1	BAG36700.1
mRNA	AY762101.1	AAX07828.1
mRNA	BC000180.2	AAH00180.1
mRNA	BC000698.2	AAH00698.1
mRNA	BC004253.1	AAH04253.1
mRNA	BC008636.1	AAH08636.1
mRNA	BC009754.2	AAH09754.3
mRNA	BC020982.1	AAH20982.1
mRNA	BC072017.1	AAH72017.1
mRNA	BG753529.1	None
mRNA	BT019412.1	AAV38219.1
mRNA	CD106591.1	None
mRNA	L32537.1	AAA73889.1
mRNA	X12876.1	CAA31369.1
mRNA	X12881.1	CAA31375.1
mRNA	X12883.1	CAA31377.1
other-genetic	DQ890555.2	ABM92172.1
other-genetic	DQ893715.2	ABM84641.1