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    KRT18 keratin 18 [ Homo sapiens ]

    Gene ID: 3875, updated on 11-May-2012
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    Summary

    Official Symbol
    KRT18provided by HGNC
    Official Full Name
    keratin 18provided by HGNC
    Primary source
    HGNC:6430
    Locus tag
    PIG46
    See related
    Ensembl:ENSG00000111057; HPRD:01020; MIM:148070; Vega:OTTHUMG00000169882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K18; CYK18
    Summary
    KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    12q13
    Sequence :
    Chromosome: 12; NC_000012.11 (53342655..53346685)
    See KRT18 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 41 Neighboring gene keratin 8 Neighboring gene eukaryotic translation initiation factor 4B Neighboring gene uncharacterized LOC283335 Neighboring gene tensin like C1 domain containing phosphatase (tensin 2)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. Redox regulation of cytokeratin 18 protein by NADPH oxidase 1 in preneoplastic human epithelial cells. Sattayakhom A, et al. J Cancer Res Clin Oncol, 2011 Nov. PMID 21877197.

    See all (150) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Redox regulation of cytokeratin 18 protein by NADPH oxidase 1 in preneoplastic human epithelial cells
      Title: Redox regulation of cytokeratin 18 protein by NADPH oxidase 1 in preneoplastic human epithelial cells.
    2. Suggest that CK18 is unsuitable for early diagnosis of tongue squamous cell carcinoma.
      Title: Quantitative expression study of four cytokeratins and p63 in squamous cell carcinoma of the tongue: suitability for sentinel node navigation surgery using one-step nucleic acid amplification.
    3. Patients with nonalcoholic steatohepatitis (NASH) had significantly higher levels of CK-18 and soluble Fas than patients in the "not NASH" group.
      Title: An apoptosis panel for nonalcoholic steatohepatitis diagnosis.
    4. the KRT8/KRT18 heterodimeric intermediary filaments of the cytoskeleton apparently are an essential component for the proper targeting of CFTR to the apical membrane in epithelial cells.
      Title: An association study on contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride secretion.
    5. speculated that chymotrypsin C might regulate pancreatic cancer cell migration in relation to cytokeratin 18 expression
      Title: Effect of chymotrypsin C and related proteins on pancreatic cancer cell migration.
    6. degradation of plectin induced by staurosporine-treatment in liver cells resulted in cytoskeleton disruption and induced morphological changes in these cells by affecting the expression and organization of cytokeratin 18.
      Title: Cytokeratin 18-mediated disorganization of intermediate filaments is induced by degradation of plectin in human liver cells.
    7. These findings reveal the potential for cytokeratin 18 to be used as a diagnostic marker for early detection of hepatosplenic schistosomiasis.
      Title: Identification of cytokeratin 18 as a biomarker of mouse and human hepatosplenic schistosomiasis.
    8. Cervical cancer cells with diminished CK18 expression are more susceptible to cytokine-induced apoptosis, particularly in response to FasL treatment.
      Title: Cytokeratin 18 expression inhibits cytokine-induced death of cervical cancer cells.
    9. evidence for increased total CK-18 serum and urine levels in chronic kidney disease patients
      Title: Increased total cytokeratin-18 serum and urine levels in chronic kidney disease.
    10. caspase-cleaved epitope M30 serum levels are associated with survival in advanced gastric carcinoma patients
      Title: Serum M30 levels are associated with survival in advanced gastric carcinoma patients.
    Submit: New GeneRIF Correction See all (74)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Cirrhosis, cryptogenic

    Cirrhosis, noncryptogenic, susceptibility to

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000215.1 NP_005179.2 CBL    BIND  PubMed c-Cbl interacts with Keratin 18. 
    NP_000215.1 NP_003780.1 TRADD    BIND  PubMed K18 interacts with TRADD. 
    P05783 Q9UQM7 CAMK2A    HPRD  PubMed  
    P05783 P42574 CASP3    HPRD  PubMed  
    P05783 P55212 CASP6    HPRD  PubMed  
    P05783 P55210 CASP7    HPRD  PubMed  
    P05783 Q14790 CASP8    HPRD  PubMed  
    P05783 P22681 CBL    HPRD  PubMed  
    P05783 Q15834 CCDC85B    HPRD  PubMed  
    P05783 P06493 CDK1    HPRD  PubMed  
    P05783 Q9UMD9 COL17A1    HPRD  PubMed  
    P05783 O75618 DEDD    HPRD  PubMed  
    P05783 O75190 DNAJB6    HPRD  PubMed  
    P05783 P00533 EGFR    HPRD  PubMed  
    P05783 Q8IYI6 EXOC8    HPRD  PubMed  
    P05783 O14964 HGS    HPRD  PubMed  
    P05783 Heat shock 70 KD protein 1A HSPA1A    HPRD  PubMed  
    P05783 P11021 HSPA5    HPRD  PubMed  
    P05783 P19012 KRT15    HPRD  PubMed  
    P05783 P13647 KRT5    HPRD  PubMed  
    P05783 P05787 KRT8    HPRD  PubMed  
    P05783 O95751 LDOC1    HPRD  PubMed  
    P05783 Q16539 MAPK14    HPRD  PubMed  
    P05783 Q9Y5B8 NME7    HPRD  PubMed  
    P05783 P98161 PKD1    HPRD  PubMed  
    P05783 Q99959 PKP2    HPRD  PubMed  
    P05783 Q9H307 PNN    HPRD  PubMed  
    P05783 P17252 PRKCA    HPRD  PubMed  
    P05783 Q02156 PRKCE    HPRD  PubMed  
    P05783 P04049 RAF1    HPRD  PubMed  
    P05783 Q8IUC4 RHPN2    HPRD  PubMed  
    P05783 P51812 RPS6KA3    HPRD  PubMed  
    P05783 P05121 SERPINE1    HPRD  PubMed  
    P05783 P29353 SHC1    HPRD  PubMed  
    P05783 Trichoplein TCHP    HPRD  PubMed  
    P05783 P20333 TNFRSF1B    HPRD  PubMed  
    P05783 Q15628 TRADD    HPRD  PubMed  
    P05783 P23258 TUBG1    HPRD  PubMed  
    P05783 Gamma tubulin ring complex protein TUBGCP4    HPRD  PubMed  
    P05783 O75445 USH2A    HPRD  PubMed  
    P05783 P31946 YWHAB    HPRD  PubMed  
    P05783 P62258 YWHAE    HPRD  PubMed  
    P05783 P61981 YWHAG    HPRD  PubMed  
    P05783 Q04917 YWHAH    HPRD  PubMed  
    P05783 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:110073 BioGRID:106739 ALK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110073 BioGRID:107315 CBL    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:116198 CCDC85B    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:112978 CLEC3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110073 BioGRID:107704 COL17A1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110073 BioGRID:114627 DEDD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110073 BioGRID:115360 DNAJB6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110073 BioGRID:127206 EXOC8    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110073 BioGRID:114593 HGS    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:109540 HSPA4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110073 BioGRID:110064 KRT15    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:110050 KRT5    BioGRID  PubMed Co-purification 
    BioGRID:110073 BioGRID:126715 KRT72    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:110054 KRT8    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:117169 LDOC1    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:110333 MCC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110073 BioGRID:118963 NME7    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:111327 PKD1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110073 BioGRID:111335 PKP2    BioGRID  PubMed Reconstituted Complex 
    NP_009114.1 PKP3    BIND  PubMed PKP3 interacts with KRT18 (CK18) 
    BioGRID:110073 BioGRID:116357 PKP3    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:111412 PNN    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110073 BioGRID:111490 PPM1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110073 BioGRID:111567 PRKCE    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110073 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110073 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110073 BioGRID:112496 SUMO3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110073 BioGRID:112707 SVIL    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:112987 TNFRSF1B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110073 BioGRID:114257 TRADD    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110073 BioGRID:118078 TUBGCP4    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110073 BioGRID:124189 USP32    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110073 BioGRID:113364 YWHAG    BioGRID  PubMed Two-hybrid 
    BioGRID:110073 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
      Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    Golgi to plasma membrane CFTR protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intermediate filament TAS
    Traceable Author Statement
    more info
    		 PubMed 
    keratin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    keratin, type I cytoskeletal 18
    Names
    keratin, type I cytoskeletal 18
    CK-18
    keratin-18
    cytokeratin 18
    cytokeratin-18
    cell proliferation-inducing protein 46
    cell proliferation-inducing gene 46 protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008351.1 RefSeqGene

      Range
      5001..9031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000224.2 → NP_000215.1  keratin, type I cytoskeletal 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC000180, CD106591, X12881
      Consensus CDS
      CCDS31809.1
      UniProtKB/Swiss-Prot
      P05783
      Related
      ENSP00000373487, OTTHUMP00000242378, ENST00000388835, OTTHUMT00000406405
      Conserved Domains (1) summary
      pfam00038
      Location:79 – 389
      Blast Score: 926
      Filament; Intermediate filament protein

    2. NM_199187.1 → NP_954657.1  keratin, type I cytoskeletal 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC000180, BG753529, CD106591, X12881
      Consensus CDS
      CCDS31809.1
      UniProtKB/Swiss-Prot
      P05783
      Related
      ENSP00000373489, ENST00000388837
      Conserved Domains (1) summary
      pfam00038
      Location:79 – 389
      Blast Score: 926
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      53342655..53346685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      50386471..50390501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC107016.20 (18687..22717) None
    genomic AF179904.1 AAA59461.1
    genomic CH471054.1 EAW96655.1
      EAW96656.1
    genomic HC921479.1 CBU83085.1
    genomic HD063881.1 CBU30436.1
    mRNA AK129587.1 None
    mRNA AK223093.1 BAD96813.1
    mRNA AK308506.1 None
    mRNA AK313988.1 BAG36700.1
    mRNA AY762101.1 AAX07828.1
    mRNA BC000180.2 AAH00180.1
    mRNA BC000698.2 AAH00698.1
    mRNA BC004253.1 AAH04253.1
    mRNA BC008636.1 AAH08636.1
    mRNA BC009754.2 AAH09754.3
    mRNA BC020982.1 AAH20982.1
    mRNA BC072017.1 AAH72017.1
    mRNA BG753529.1 None
    mRNA BT019412.1 AAV38219.1
    mRNA CD106591.1 None
    mRNA L32537.1 AAA73889.1
    mRNA X12876.1 CAA31369.1
    mRNA X12881.1 CAA31375.1
    mRNA X12883.1 CAA31377.1
    other-genetic DQ890555.2 ABM92172.1
    other-genetic DQ893715.2 ABM84641.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05783.2 GenPept UniProtKB/Swiss-Prot:P05783
    Q15899 GenPept UniProtKB/TrEMBL:Q15899
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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