ple pale [Drosophila melanogaster] - Gene

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Summary

Official Symbol: pleprovided by Flybase
Official Full Name: paleprovided by Flybase
Primary source: FLYBASE:FBgn0005626
Locus tag: Dmel_CG10118
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10118; DH65B; Dmel\CG10118; DTH; dTH1; dTH65B; Pale; pale/ple; Th; TH; VII

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Genomic context

Location :: 65C3-65C3; 3-18 cM

Sequence :: Chromosome: 3L; NT_037436.3 (6706455..6712624, complement)

See ple in Epigenomics, MapViewer

Chromosome 3L - NT_037436.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

activity of tyrosine hydroxylase is also increased by this interaction, in excess of the stimulation resulting from phosphorylation alone
Title: Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis.
The biochemically conserved regulatory mechanisms of recombinant DTH parallel those from mammals.
Title: Biochemical conservation of recombinant Drosophila tyrosine hydroxylase with its mammalian cognates.
maternal as well as embryonic effects on the secretion and/or functionality of Tyrosine hydroxylase (pale) may play roles in the early developmental program of the organism.
Title: Maternal and embryonic sources of tyrosine hydroxylase during Drosophila embryogenesis.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:64196	BioGRID:57628	CG11380	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:66425	CG14684	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:58073	CG3342	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:67996	CG5112	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:64643	CG6175	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:65440	CG7757	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:68389	CG7824	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:624876	CR11700	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:61175	Ddc	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:64196	BioGRID:65272	MED19	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:61822	Map60	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:60555	Nup107	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:70027	Pk17E	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:68753	Plap	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:63049	Pu	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:64196	BioGRID:67443	RpS30	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:63077	Sdc	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:59332	cactin	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:66207	hb	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:63143	mei-S332	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:77553	mld	BioGRID	PubMed	Two-hybrid
BioGRID:64196	BioGRID:64438	smg	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the ple gene: The ple gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, and C.elegans.

Pathways from BioSystems

Amine-derived hormones, organism-specific biosystem (from REACTOME)
Amine-derived hormones, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Biogenic Amine Synthesis, organism-specific biosystem (from WikiPathways)
Biogenic Amine Synthesis, organism-specific biosystemBiogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepin...
Catecholamine biosynthesis, organism-specific biosystem (from REACTOME)
Catecholamine biosynthesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
Metabolism of amino acids and derivatives, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Tyrosine metabolism, organism-specific biosystem (from KEGG)
Tyrosine metabolism, organism-specific biosystem
Tyrosine metabolism
Tyrosine metabolism, conserved biosystem (from KEGG)
Tyrosine metabolism, conserved biosystem
Tyrosine metabolism

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
iron ion binding	IEA Inferred from Electronic Annotation more info
tyrosine 3-monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
tyrosine 3-monooxygenase activity	NAS Non-traceable Author Statement more info	PubMed
tyrosine 3-monooxygenase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
adult chitin-containing cuticle pigmentation	IMP Inferred from Mutant Phenotype more info
adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
aromatic amino acid family metabolic process	IEA Inferred from Electronic Annotation more info
catecholamine metabolic process	NAS Non-traceable Author Statement more info	PubMed
courtship behavior	NAS Non-traceable Author Statement more info	PubMed
cuticle pigmentation	IMP Inferred from Mutant Phenotype more info
developmental pigmentation	TAS Traceable Author Statement more info	PubMed
dopamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
dopamine metabolic process	IMP Inferred from Mutant Phenotype more info
male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
oxidation-reduction process	IEA Inferred from Electronic Annotation more info
regulation of adult chitin-containing cuticle pigmentation	IGI Inferred from Genetic Interaction more info
regulation of adult chitin-containing cuticle pigmentation	IMP Inferred from Mutant Phenotype more info
regulation of dopamine metabolic process	NAS Non-traceable Author Statement more info
regulation of epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
thermosensory behavior	IMP Inferred from Mutant Phenotype more info
thermotaxis	IMP Inferred from Mutant Phenotype more info
wing disc development	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info

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General protein information

Preferred Names: CG10118 gene product from transcript CG10118-RA

Names: CG10118-PA; CG10118-PB; Tyrosine-3-hydroxylase; XBB70 group VII; drosophila tyrosine hydroxylase; pale; ple-PA; ple-PB; tyrosine hydrodroxylase; tyrosine hydroxylase; tyrosine-hydroxylase

NP_476897.1

EC 1.14.16.2

NP_476898.1

EC 1.14.16.2

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.3

Range

6706455..6712624, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057549.2 → NP_476897.1 pale, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P18459

Related

FBpp0076665, FBtr0076956

Conserved Domains (3) summary

cd03345
Location:173 – 470
Blast Score: 1404

eu_TyrOH; Eukaryotic tyrosine hydroxylase (TyrOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic ...

TIGR01269
Location:48 – 505
Blast Score: 1992

Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric

cd04930
Location:48 – 163
Blast Score: 308

ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
NM_057550.3 → NP_476898.1 pale, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

B5X0J4

UniProtKB/Swiss-Prot

P18459

Related

FBpp0076666, FBtr0076957

Conserved Domains (3) summary

cd03345
Location:244 – 541
Blast Score: 1399

eu_TyrOH; Eukaryotic tyrosine hydroxylase (TyrOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic ...

TIGR01269
Location:130 – 576
Blast Score: 1952

Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric

cl09141
Location:130 – 234
Blast Score: 267

ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	U14395.1	AAA62877.1
genomic	AE014296.4	AAN12080.1
mRNA	X76209.1	CAA53802.1
genomic	U14395.1	AAA62876.1
genomic	AE014296.4	AAF50648.1
mRNA	BT044563.1	ACI15758.1