Mir122a microRNA 122a [Mus musculus] - Gene

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Summary

Official Symbol: Mir122aprovided by MGI
Official Full Name: microRNA 122aprovided by MGI
Primary source: MGI:2676805
See related: miRBase:MI0000256
Gene type: miscRNA
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mirn122a; mmu-mir-122
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

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Genomic context

Location :: 18; 18

Sequence :: Chromosome: 18; NC_000084.6 (65248861..65248926)

See Mir122a in Epigenomics, MapViewer

Chromosome 18 - NC_000084.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hepatocyte differentiation is directed by a positive feedback loop that includes a transcription factor (HNF6) and a microRNA (miR-122) that are specifically expressed in liver.
Title: A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation.
miRNA122a-mediated antigen silencing induced significantly higher anti-HBsAg antibody titers allowing an up to 100-fold vector dose reduction.
Title: miRNA-mediated silencing in hepatocytes can increase adaptive immune responses to adenovirus vector-delivered transgenic antigens.
TCDD dysregulates the expression of miR101a and miR122.
Title: Involvement of microRNAs in dioxin-induced liver damage in the mouse.
TNF-alpha regulates intestinal tight junction permeability by inducing miR-122a-mediated degradation of occludin mRNA.
Title: MicroRNA regulation of intestinal epithelial tight junction permeability.
MicroRNA122 is a key regulator of alpha-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma.
Title: MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma.
increased Hamp mRNA levels and subsequent iron deficiency in mice with reduced miR-122 levels establish a direct mechanistic link between miR-122 and the regulation of systemic iron metabolism
Title: The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice.
Results suggust that miR-122 regulates the expression of a large number of target mRNAs in adult mouse liver.
Title: Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver.
miR-122 had a negative correlation with acute liver failure and positive correlations with TNFa and IL-6.
Title: [The role of miRNA-122 expression during the acute liver failure in mice induced by D-GalN/LPS].
miR-370 acting via miR-122 may have a causative role in the accumulation of hepatic triglycerides by modulating initially the expression of SREBP-1c, DGAT2, and Cpt1alpha.
Title: MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism.
specific microRNA species, such as mir-122 and mir-192, both are enriched in the liver tissue and exhibit dose- and exposure duration-dependent changes in the plasma that parallel serum aminotransferase levels and the histopathology of liver degeneration
Title: Circulating microRNAs, potential biomarkers for drug-induced liver injury.

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Process	Evidence Code	Pubs
cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info
erythrocyte differentiation	IGI Inferred from Genetic Interaction more info
multicellular organismal iron ion homeostasis	IGI Inferred from Genetic Interaction more info
regulation of gene expression	IGI Inferred from Genetic Interaction more info

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.