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    SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 387082, updated on 13-May-2012

    Summary

    Official Symbol
    SUMO4provided by HGNC
    Official Full Name
    SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:21181
    See related
    Ensembl:ENSG00000177688; HPRD:10584; MIM:608829; Vega:OTTHUMG00000015785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IDDM5; SMT3H4; SUMO-4; dJ281H8.4
    Summary
    This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    6q25
    Sequence :
    Chromosome: 6; NC_000006.11 (149721495..149722182)
    See SUMO4 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene uronyl-2-sulfotransferase Neighboring gene uncharacterized LOC100128176 Neighboring gene small nuclear ribonucleoprotein polypeptide B pseudogene Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 2 Neighboring gene zinc finger CCCH-type containing 12D Neighboring gene coiled-coil domain containing 59 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q6EEV6 P11310 ACADM    HPRD  PubMed  
    Q6EEV6 Q99798 ACO2    HPRD  PubMed  
    Q6EEV6 P63261 ACTG1    HPRD  PubMed  
    Q6EEV6 P04075 ALDOA    HPRD  PubMed  
    Q6EEV6 P52565 ARHGDIA    HPRD  PubMed  
    Q6EEV6 P06576 ATP5B    HPRD  PubMed  
    Q6EEV6 P27797 CALR    HPRD  PubMed  
    Q6EEV6 P04040 CAT    HPRD  PubMed  
    Q6EEV6 P78371 CCT2    HPRD  PubMed  
    Q6EEV6 P48643 CCT5    HPRD  PubMed  
    Q6EEV6 P40227 CCT6A    HPRD  PubMed  
    Q6EEV6 Q99832 CCT7    HPRD  PubMed  
    Q6EEV6 O00299 CLIC1    HPRD  PubMed  
    Q6EEV6 P31689 DNAJA1    HPRD  PubMed  
    Q6EEV6 Q9UBS4 DNAJB11    HPRD  PubMed  
    Q6EEV6 Q13347 EIF3I    HPRD  PubMed  
    Q6EEV6 P06733 ENO1    HPRD  PubMed  
    Q6EEV6 P09104 ENO2    HPRD  PubMed  
    Q6EEV6 P01100 FOS    HPRD  PubMed  
    Q6EEV6 P11413 G6PD    HPRD  PubMed  
    Q6EEV6 P04406 GAPDH    HPRD  PubMed  
    Q6EEV6 P49915 GMPS    HPRD  PubMed  
    Q6EEV6 P63244 GNB2L1    HPRD  PubMed  
    Q6EEV6 P09211 GSTP1    HPRD  PubMed  
    Q6EEV6 Q14103 HNRNPD    HPRD  PubMed  
    Q6EEV6 P52597 HNRNPF    HPRD  PubMed  
    Q6EEV6 P31943 HNRNPH1    HPRD  PubMed  
    Q6EEV6 P14866 HNRNPL    HPRD  PubMed  
    Q6EEV6 P08107 HSPA1B    HPRD  PubMed  
    Q6EEV6 P11021 HSPA5    HPRD  PubMed  
    Q6EEV6 P11142 HSPA8    HPRD  PubMed  
    Q6EEV6 P38646 HSPA9    HPRD  PubMed  
    Q6EEV6 P10809 HSPD1    HPRD  PubMed  
    Q6EEV6 O75874 IDH1    HPRD  PubMed  
    Q6EEV6 P50213 IDH3A    HPRD  PubMed  
    Q6EEV6 P12268 IMPDH2    HPRD  PubMed  
    Q6EEV6 P05412 JUN    HPRD  PubMed  
    Q6EEV6 P07195 LDHB    HPRD  PubMed  
    Q6EEV6 P02545 LMNA    HPRD  PubMed  
    Q6EEV6 P20700 LMNB1    HPRD  PubMed  
    Q6EEV6 P82650 MRPS22    HPRD  PubMed  
    Q6EEV6 P25963 NFKBIA    HPRD  PubMed  
    Q6EEV6 P04150 NR3C1    HPRD  PubMed  
    Q6EEV6 Q9UQ80 PA2G4    HPRD  PubMed  
    Q6EEV6 Q15102 PAFAH1B3    HPRD  PubMed  
    Q6EEV6 P30101 PDIA3    HPRD  PubMed  
    Q6EEV6 Q15084 PDIA6    HPRD  PubMed  
    Q6EEV6 P00558 PGK1    HPRD  PubMed  
    Q6EEV6 P35232 PHB    HPRD  PubMed  
    Q6EEV6 O43175 PHGDH    HPRD  PubMed  
    Q6EEV6 HT014 PITHD1    HPRD  PubMed  
    Q6EEV6 Q15181 PPA1    HPRD  PubMed  
    Q6EEV6 P32119 PRDX2    HPRD  PubMed  
    Q6EEV6 P30048 PRDX3    HPRD  PubMed  
    Q6EEV6 Q13162 PRDX4    HPRD  PubMed  
    Q6EEV6 P30041 PRDX6    HPRD  PubMed  
    Q6EEV6 P60891 PRPS1    HPRD  PubMed  
    Q6EEV6 P35998 PSMC2    HPRD  PubMed  
    Q6EEV6 P08865 RPSA    HPRD  PubMed  
    Q6EEV6 Q15427 SF3B4    HPRD  PubMed  
    Q6EEV6 O43291 SPINT2    HPRD  PubMed  
    Q6EEV6 P42224 STAT1    HPRD  PubMed  
    Q6EEV6 P40763 STAT3    HPRD  PubMed  
    Q6EEV6 P31948 STIP1    HPRD  PubMed  
    Q6EEV6 Q9UJZ1 STOML2    HPRD  PubMed  
    Q6EEV6 Q9Y3F4 STRAP    HPRD  PubMed  
    Q6EEV6 P05549 TFAP2A    HPRD  PubMed  
    Q6EEV6 P11388 TOP2A    HPRD  PubMed  
    Q6EEV6 P06753 TPM3    HPRD  PubMed  
    Q6EEV6 Q9BQE3 TUBA1C    HPRD  PubMed  
    Q6EEV6 O43396 TXNL1    HPRD  PubMed  
    Q6EEV6 Ubiquitin conjugating enzyme E2 variant 1 UBE2V1    HPRD  PubMed  
    Q6EEV6 P55072 VCP    HPRD  PubMed  
    Q6EEV6 P21796 VDAC1    HPRD  PubMed  
    Q6EEV6 O75312 ZNF259    HPRD  PubMed  
    BioGRID:132223 BioGRID:106552 ACADM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:106566 ACO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:106586 ACTG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:106728 ALDOA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:106889 ARHGDIA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:119115 ARHGEF3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:132223 BioGRID:106999 ATP5E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:119569 C22orf28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:107223 CA9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:107262 CALR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:107297 CAT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:115827 CCT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:116603 CCT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:107346 CCT6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:115825 CCT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:107604 CLIC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:113607 CXCR4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109534 DNAJA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:119699 DNAJB11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:114217 EIF3I    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:108338 ENO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:108340 ENO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:116704 ERP44    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:108636 FOS    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:132223 BioGRID:108814 G6PD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:108868 GAPDH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:114360 GMPS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109191 GSR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109205 GSTP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109425 HNRNPD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109426 HNRNPF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109428 HNRNPH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109431 HNRNPK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109432 HNRNPL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109535 HSPA1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109536 HSPA1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109541 HSPA5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109545 HSPA9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109561 HSPD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109643 IDH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109645 IDH3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109827 IMPDH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:132223 BioGRID:110137 LDHB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:110186 LMNA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:110187 LMNB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:121269 MRPS22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:110859 NFKBIA    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:132223 BioGRID:131486 NME9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:110904 NONO    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109165 NR3C1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:132223 BioGRID:111075 PA2G4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:111087 PAFAH1B3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:109180 PDIA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:115434 PDIA6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:111251 PGK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:111264 PHB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:117618 PHGDH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:121363 PITHD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:111330 PKLR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:111440 PON1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:111460 PPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:112860 PRDX2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:116136 PRDX3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:115800 PRDX4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:114956 PRDX6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:111615 PRPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:111674 PSMC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:111678 PSMC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:110115 RPSA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:115554 SF3B4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:106788 SLC25A4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:112530 SOD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:115896 SPINT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:112649 STAT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:132223 BioGRID:116162 STIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:119062 STOML2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:116342 STRAP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:112878 TFAP2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:132223 BioGRID:113006 TOP2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:113023 TPM3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:124259 TUBA1C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:113135 TUFM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:114755 TXNL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:113183 UBE2V1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:113259 VDAC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:113272 VIM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:116272 WDR5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:132223 BioGRID:114401 ZNF259    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Genotypes

    Pathways from BioSystems

    • Nuclear pore complex, organism-specific biosystem (from KEGG)
      Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...

    General protein information

    Preferred Names
    small ubiquitin-related modifier 4
    Names
    small ubiquitin-related modifier 4
    SMT3 suppressor of mif two 3 homolog 2
    small ubiquitin-like modifier 4 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012301.1 RefSeqGene

      Range
      5001..5688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001002255.1NP_001002255.1  small ubiquitin-related modifier 4

      Status: REVIEWED

      Source sequence(s)
      AY340238
      Consensus CDS
      CCDS34549.1
      UniProtKB/Swiss-Prot
      Q6EEV6
      Related
      ENSP00000318635, OTTHUMP00000017390, ENST00000326669, OTTHUMT00000042638
      Conserved Domains (2) summary
      cd01763
      Location:893
      Blast Score: 312
      Sumo; Small ubiquitin-related modifier (SUMO)
      smart00213
      Location:1886
      Blast Score: 125
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      149721495..149722182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      147288256..147288943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB205057.1 BAH05006.1
    genomic AL031133.1 CAA20019.1
    genomic CH471051.2 EAW47808.1
    mRNA AY340238.1 AAR04484.1
    mRNA BC130305.1 AAI30306.1
    other-genetic HQ258040.1 ADR82794.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6EEV6.2 GenPept UniProtKB/Swiss-Prot:Q6EEV6

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