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SUMO4 small ubiquitin-like modifier 4 [ Homo sapiens (human) ]

Gene ID: 387082, updated on 6-Jul-2014
Official Symbol
SUMO4provided by HGNC
Official Full Name
small ubiquitin-like modifier 4provided by HGNC
Primary source
HGNC:21181
See related
Ensembl:ENSG00000177688; HPRD:10584; MIM:608829; Vega:OTTHUMG00000015785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IDDM5; SMT3H4; SUMO-4; dJ281H8.4
Summary
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]
See SUMO4 in Epigenomics, MapViewer
Location:
6q25
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (149400359..149401046)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149721284..149722182)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uronyl-2-sulfotransferase Neighboring gene uncharacterized LOC101928683 Neighboring gene small nuclear ribonucleoprotein polypeptide B pseudogene Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 2 Neighboring gene zinc finger CCCH-type containing 12D Neighboring gene coiled-coil domain containing 59 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Nuclear pore complex, organism-specific biosystem (from KEGG)
    Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • Nuclear pore complex, conserved biosystem (from KEGG)
    Nuclear pore complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
small ubiquitin-related modifier 4
Names
small ubiquitin-related modifier 4
insulin-dependent diabetes mellitus 5
SMT3 suppressor of mif two 3 homolog 2
SMT3 suppressor of mif two 3 homolog 4
small ubiquitin-like modifier 4 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012301.1 

    Range
    5001..5688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002255.1NP_001002255.1  small ubiquitin-related modifier 4

    See proteins identical to NP_001002255.1

    Status: REVIEWED

    Source sequence(s)
    AY340238
    Consensus CDS
    CCDS34549.1
    UniProtKB/Swiss-Prot
    Q6EEV6
    Related
    ENSP00000318635, OTTHUMP00000017390, ENST00000326669, OTTHUMT00000042638
    Conserved Domains (1) summary
    cd01763
    Location:893
    Blast Score: 326
    Sumo; Small ubiquitin-related modifier (SUMO)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    149400359..149401046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    147288256..147288943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    149986244..149986931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)