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    Bj1 Bj1 protein [ Drosophila melanogaster ]

    Gene ID: 38669, updated on 10-May-2012
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    Summary

    Official Symbol
    Bj1provided by Flybase
    Official Full Name
    Bj1 proteinprovided by Flybase
    Primary source
    FLYBASE:FBgn0002638
    Locus tag
    Dmel_CG10480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BJ1; CG10480; CG18640 (Bj1); Dmel\CG10480; dRCC1; inxs; RanGEF; Rcc1; RCC1; sdt
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    Genomic context

    Location :
    65A1-65A1
    Sequence :
    Chromosome: 3L; NT_037436.3 (5923362..5925873, complement)
    See Bj1 in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene CG32407 gene product from transcript CG32407-RA Neighboring gene CG33523 gene product from transcript CG33523-RE Neighboring gene CG33993 gene product from transcript CG33993-RA Neighboring gene CG10479 gene product from transcript CG10479-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Structure of RCC1 chromatin factor bound to the nucleosome core particle. Makde RD, et al. Nature, 2010 Sep 30. PMID 20739938.
    3. The winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster. Hofmann A, et al. Chromosome Res, 2010 Apr. PMID 20213139.
    4. The nuclear transport machinery as a regulator of Drosophila development. Mason DA, et al. Semin Cell Dev Biol, 2009 Jul. PMID 19508860.
    5. Telomeric position effect--a third silencing mechanism in eukaryotes. Doheny JG, et al. PLoS One, 2008. PMID 19057646.

    See all (35) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. crystal structure of a complex of Drosophila RCC1 and the nucleosome core particle at 2.9 A resolution, providing an atomic view of how a chromatin protein interacts with the histone and DNA components of the nucleosome
      Title: Structure of RCC1 chromatin factor bound to the nucleosome core particle.
    2. Data show that dRCC1 is required for nuclear import of nuclear localization signal sequence (NLS)-carrying cargo molecules and for cell proliferation and/or survival during germline, eye and wing development and that dRCC1 appears to facilitate apoptosis.
      Title: The Drosophila RCC1 homolog, Bj1, regulates nucleocytoplasmic transport and neural differentiation during Drosophila development.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:64129 BioGRID:70214 CG11899    BioGRID  PubMed Two-hybrid 
    BioGRID:64129 BioGRID:58656 CG12723    BioGRID  PubMed Two-hybrid 
    BioGRID:64129 BioGRID:59001 CG13005    BioGRID  PubMed Two-hybrid 
    BioGRID:64129 BioGRID:57754 CG2865    BioGRID  PubMed Two-hybrid 
    BioGRID:64129 BioGRID:68613 CG31999    BioGRID  PubMed Two-hybrid 
    BioGRID:64129 BioGRID:61336 E2f2    BioGRID  PubMed Two-hybrid 
    BioGRID:64129 BioGRID:62401 HPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:64129 BioGRID:61232 Hakai    BioGRID  PubMed Two-hybrid 
    BioGRID:64129 BioGRID:61202 RanGap    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:64129 BioGRID:68501 zfh1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Bj1 gene: The Bj1 gene is conserved in human, chimpanzee, dog, cow, mouse, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, and P.falciparum.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    Ran guanyl-nucleotide exchange factor activity NAS
    Non-traceable Author Statement
    more info
    		  
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    central nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromosome condensation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mitotic chromosome condensation NAS
    Non-traceable Author Statement
    more info
    		  
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG10480 gene product from transcript CG10480-RA
    Names
    Bj1 protein
    Bj1-PA
    Bj1-PB
    Bj1-PC
    CG10480-PA
    CG10480-PB
    CG10480-PC
    in excess
    side-out
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      5923362..5925873, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079219.3 → NP_523943.1  Bj1 protein, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25171
      Related
      FBpp0076782, FBtr0077074
      Conserved Domains (2) summary
      pfam00415
      Location:363 – 414
      Blast Score: 119
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:131 – 158
      Blast Score: 96
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    2. NM_168152.2 → NP_729119.1  Bj1 protein, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25171
      Related
      FBpp0076784, FBtr0077076
      Conserved Domains (2) summary
      pfam00415
      Location:363 – 414
      Blast Score: 119
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:131 – 158
      Blast Score: 96
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    3. NM_168151.2 → NP_729118.1  Bj1 protein, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25171
      Related
      FBpp0076783, FBtr0077075
      Conserved Domains (2) summary
      pfam00415
      Location:363 – 414
      Blast Score: 119
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:131 – 158
      Blast Score: 96
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA AY070540.1 AAL48011.1
    genomic AE014296.4 AAN12235.1
    genomic AE014296.4 AAF50726.1
    genomic AE014296.4 AAF50727.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25171.2 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content