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KRT14 keratin 14 [ Homo sapiens (human) ]

Gene ID: 3861, updated on 8-May-2016
Official Symbol
KRT14provided by HGNC
Official Full Name
keratin 14provided by HGNC
Primary source
HGNC:HGNC:6416
See related
Ensembl:ENSG00000186847 HPRD:01017; MIM:148066; Vega:OTTHUMG00000133426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K14; NFJ; CK14; EBS3; EBS4
Summary
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (41582279..41586895, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39738531..39743147, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 974 Neighboring gene keratin 9 Neighboring gene keratin 16 Neighboring gene keratin 17

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
keratin filament binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
aging IDA
Inferred from Direct Assay
more info
PubMed 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hair cycle IDA
Inferred from Direct Assay
more info
PubMed 
hemidesmosome assembly TAS
Traceable Author Statement
more info
 
intermediate filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
response to zinc ion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell periphery IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
keratin filament IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
keratin, type I cytoskeletal 14
Names
cytokeratin 14
cytokeratin-14
keratin 14, type I
keratin-14

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008624.1 RefSeqGene

    Range
    5001..9617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000526.4NP_000517.2  keratin, type I cytoskeletal 14

    See identical proteins and their annotated locations for NP_000517.2

    Status: REVIEWED

    Source sequence(s)
    BC002690, BC019097, BC042437, DB018715
    Consensus CDS
    CCDS11400.1
    UniProtKB/Swiss-Prot
    P02533
    Related
    ENSP00000167586, OTTHUMP00000164624, ENST00000167586, OTTHUMT00000257289
    Conserved Domains (1) summary
    pfam00038
    Location:114425
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    41582279..41586895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    39973838..39978454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)