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KRT12 keratin 12 [ Homo sapiens (human) ]

Gene ID: 3859, updated on 30-Oct-2014
Official Symbol
KRT12provided by HGNC
Official Full Name
keratin 12provided by HGNC
Primary source
HGNC:HGNC:6414
See related
Ensembl:ENSG00000187242; HPRD:03405; MIM:601687; Vega:OTTHUMG00000133369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K12
Summary
KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008]
See KRT12 in Epigenomics, MapViewer
Location:
17q12
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (40861178..40867210, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39017430..39023462, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 28 Neighboring gene transmembrane protein 99 Neighboring gene keratin 10 Neighboring gene keratin 20 Neighboring gene keratin 23 (histone deacetylase inducible)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
visual perception TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
keratin, type I cytoskeletal 12
Names
keratin, type I cytoskeletal 12
CK-12
keratin-12
cytokeratin-12

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008077.1 

    Range
    5001..11033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000223.3NP_000214.1  keratin, type I cytoskeletal 12

    See proteins identical to NP_000214.1

    Status: REVIEWED

    Source sequence(s)
    CV573989, D78367
    Consensus CDS
    CCDS11378.1
    UniProtKB/Swiss-Prot
    Q99456
    Related
    ENSP00000251643, OTTHUMP00000164524, ENST00000251643, OTTHUMT00000257214
    Conserved Domains (1) summary
    pfam00038
    Location:124436
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NW_003871091.1 

    Range
    10446..16478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    40861178..40867210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    34811768..34817815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    39252770..39258802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)