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    KRT10 keratin 10 [ Homo sapiens (human) ]

    Gene ID: 3858, updated on 9-Jun-2013
    Official Symbol
    KRT10provided by HGNC
    Official Full Name
    keratin 10provided by HGNC
    Primary source
    HGNC:6413
    See related
    Ensembl:ENSG00000186395; HPRD:01021; MIM:148080; Vega:OTTHUMG00000133368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BIE; EHK; K10; KPP; BCIE; CK10
    Summary
    This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
    Location :
    17q21
    Sequence :
    Chromosome: 17; NC_000017.10 (38974369..38978863, complement)
    See KRT10 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene keratin 27 Neighboring gene keratin 28 Neighboring gene transmembrane protein 99 Neighboring gene keratin 12 Neighboring gene keratin 20

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Bett JS, et al. Biochem J, 2013 Apr 15. PMID 23398456.
    2. Epidemiology and clinical characteristics of bullous congenital ichthyosiform erythroderma (keratinolytic ichthyosis) in Japan: results from a nationwide survey. Kurosawa M, et al. J Am Acad Dermatol, 2013 Feb. PMID 23182068.
    3. Molecular mimicry between HSP 65 of Mycobacterium leprae and cytokeratin 10 of the host keratin; role in pathogenesis of leprosy. Singh I, et al. Cell Immunol, 2012 Jul-Aug. PMID 23121977.
    4. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. Singh G, et al. Cell, 2012 Nov 9. PMID 23084401.
    5. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.

    See all (80) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Most of the orthokeratotic dysplasia constituent cells were immunopositive for keratin 10, but not for keratins 13, 17 or 19.
      Title: Keratin 10-positive orthokeratotic dysplasia: a new leucoplakia-type precancerous entity of the oral mucosa.
    2. Among Japanese patients with bullous congenital ichthyosiform erythroderma for which genetic diagnosis was determined, all showed mustations in KRT1 or KRT10.
      Title: Epidemiology and clinical characteristics of bullous congenital ichthyosiform erythroderma (keratinolytic ichthyosis) in Japan: results from a nationwide survey.
    3. Molecular mimicry between HSP 65 of Mycobacterium leprae and cytokeratin 10 of the host keratin play the role in pathogenesis of leprosy.
      Title: Molecular mimicry between HSP 65 of Mycobacterium leprae and cytokeratin 10 of the host keratin; role in pathogenesis of leprosy.
    4. Pneumococcal ligands K10, laminin receptor and platelet-activating factor receptor are elevated in aged lungs and contribute to the enhanced susceptibility to pneumonia.
      Title: Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia.
    5. mutation analysis in patients with epidermolytic ichthyosis by direct sequencing of KRT1 and KRT10 genes; identified 14 different mutations, of which four have not been published previously
      Title: Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis.
    6. mapping and identifying disease-causing mutations in gene encoding KRT10 in ichthyosis with confetti; high frequency of somatic reversion suggests revertant stem cell clones are under positive selection and/or rate of mitotic recombination is elevated
      Title: Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10.
    7. Data show that TIMP-1 and cytokeratin-10 were identified as 2 newly synthesized secreted proteins in
      Title: Profiling pancreatic cancer-secreted proteome using 15N amino acids and serum-free media.
    8. Expression was altered in oral lichen planus lesions
      Title: Expression of cytokeratins 10, 13, 14 and 19 in oral lichen planus.
    9. premature termination codon of KRT10 maybe involved in recessive epidermolytic hyperkeratosis
      Title: Recessive epidermolytic hyperkeratosis caused by a previously unreported termination codon mutation in the keratin 10 gene.
    10. EHK is an autosomal dominant disorder of keratinization, caused by mutations in either the KRT1 or KRT10 genes. Our patient presents EHK with palmoplantar involvement and KRT10 mutation.
      Title: Epidermolytic hyperkeratosis with palmoplantar keratoderma in a patient with KRT10 mutation.
    Submit: New GeneRIF Correction See all (23)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    P13645 P31749 AKT1    HPRD  PubMed  
    P13645 Q92817 EVPL    HPRD  PubMed  
    P13645 Q05513 PRKCZ    HPRD  PubMed  
    P13645 P84022 SMAD3    HPRD  PubMed  
    BioGRID:110056 BioGRID:125226 AHNAK2    BioGRID  PubMed Co-fractionation 
    BioGRID:110056 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:110056 BioGRID:106715 ALB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:107587 AP2M1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:107788 CRK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:114031 CUL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:114028 CUL4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:113743 CUL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:229729 Cep290    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:119920 DCUN1D1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:115119 EIF4A3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:108309 ELAVL1    BioGRID  PubMed Co-fractionation 
    BioGRID:110056 BioGRID:108374 EPS15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:108995 GLE1    BioGRID  PubMed Two-hybrid 
    BioGRID:110056 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:109848 INPPL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:115015 IQCB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:200780 Invs    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:235913 Iqcb1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:110046 KRT1    BioGRID  PubMed Co-fractionation 
    BioGRID:110056 BioGRID:110047 KRT2    BioGRID  PubMed Co-fractionation 
    BioGRID:110056 BioGRID:110290 MAGOH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:110455 MME    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:207511 Nphp1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:234431 Nphp4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:115252 PAN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:111314 PIK3R2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:111456 POU5F1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:110056 BioGRID:111576 PRKCZ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110056 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:112937 TJP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:117577 TRAF3IP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:124390 UBASH3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:119509 UCHL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110056 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    structural constituent of epidermis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    keratinocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    intermediate filament NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    keratin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    keratin, type I cytoskeletal 10
    Names
    keratin, type I cytoskeletal 10
    CK-10
    keratin-10
    cytokeratin 10

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008405.1 RefSeqGene

      Range
      5001..9495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000421.3 → NP_000412.3  keratin, type I cytoskeletal 10

      Status: REVIEWED

      Source sequence(s)
      BC034697, CU455823, M77663
      Consensus CDS
      CCDS11377.1
      UniProtKB/Swiss-Prot
      P13645
      Related
      ENSP00000269576, OTTHUMP00000165049, ENST00000269576, OTTHUMT00000257875
      Conserved Domains (1) summary
      pfam00038
      Location:145 – 454
      Blast Score: 934
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p10 Primary Assembly

      Range
      38974369..38978863, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      34768729..34773223, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018928.1 Alternate CHM1_1.0

      Range
      39761298..39765792, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01031821.1 (82943..87437) None
    genomic AC090283.7 (28139..32617) None
    genomic AMYH01008384.1 (585910..586648) None
    genomic AMYH01008385.1 None
    genomic CH471152.1 EAW60680.1
      EAW60681.1
    genomic L20218.1 AAB59438.1
    genomic L20219.1 AAB59439.1
    genomic X14487.1 CAA32649.1
    mRNA BC034697.1 AAH34697.1
    mRNA CU455823.1 None
    mRNA J04029.1 AAA60544.1
    mRNA M19156.1 AAA59468.1
    mRNA M77663.1 AAA59199.1
    other-genetic DQ893356.2 ABM84282.1
    other-genetic DQ896675.2 ABM87674.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13645.6 GenPept UniProtKB/Swiss-Prot:P13645

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • GTR
        GTR associated with a gene
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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