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KRT10 keratin 10 [ Homo sapiens (human) ]

Gene ID: 3858, updated on 17-Apr-2014
Official Symbol
KRT10provided by HGNC
Official Full Name
keratin 10provided by HGNC
Primary source
HGNC:6413
See related
Ensembl:ENSG00000186395; HPRD:01021; MIM:148080; Vega:OTTHUMG00000133368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIE; EHK; K10; KPP; BCIE; CK10
Summary
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
Location :
17q21
Sequence :
Chromosome: 17; NC_000017.11 (40818117..40822611, complement)
See KRT10 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 27 Neighboring gene keratin 28 Neighboring gene transmembrane protein 99 Neighboring gene keratin 12 Neighboring gene keratin 20

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
    Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • Staphylococcus aureus infection, conserved biosystem (from KEGG)
    Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of epidermis NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
keratinocyte differentiation IEP
Inferred from Expression Pattern
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
keratin filament IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
keratin, type I cytoskeletal 10
Names
keratin, type I cytoskeletal 10
CK-10
keratin-10
cytokeratin 10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008405.1 RefSeqGene

    Range
    5001..9495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000421.3NP_000412.3  keratin, type I cytoskeletal 10

    Status: REVIEWED

    Source sequence(s)
    BC034697, CU455823, M77663
    Consensus CDS
    CCDS11377.1
    UniProtKB/Swiss-Prot
    P13645
    Related
    ENSP00000269576, OTTHUMP00000165049, ENST00000269576, OTTHUMT00000257875
    Conserved Domains (1) summary
    pfam00038
    Location:145454
    Blast Score: 962
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11

    Range
    40818117..40822611, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257343.1XP_005257400.1  

    Conserved Domains (1) summary
    pfam00038
    Location:145454
    Blast Score: 985
    Filament; Intermediate filament protein

Alternate HuRef

Genomic

  1. AC_000149.1 Alternate HuRef

    Range
    34768729..34773223, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    39209679..39214200, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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