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dyl dusky-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38531, updated on 4-Apr-2024

Summary

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Official Symbol
dylprovided by FlyBase
Official Full Name
dusky-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0066365
Locus tag
Dmel_CG15013
See related
AllianceGenome:FB:FBgn0066365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15013; Dmel\CG15013; Dyl
Summary
Predicted to be a structural constituent of chitin-based cuticle. Involved in several processes, including apical constriction; cell-matrix adhesion; and regulation of embryonic cell shape. Located in apical plasma membrane. Is expressed in adult head; embryonic/larval posterior spiracle; presumptive embryonic/larval system; and trichome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
64B1-64B1; 3-12 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4294004..4307718, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4294004..4307718, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Hexosaminidase 1 Neighboring gene uncharacterized protein Neighboring gene Ferredoxin 2 Neighboring gene claspin Neighboring gene Peroxisomal Membrane Protein 34 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenotypic robustness conferred by apparently redundant transcriptional enhancers. Frankel N, et al. Nature, 2010 Jul 22. PMID 20512118, Free PMC Article
  2. Mechano-chemical enforcement of tendon apical ECM into nano-filaments during Drosophila flight muscle development. Chu WC, et al. Curr Biol, 2021 Apr 12. PMID 33545042
  3. ChtVis-Tomato, a genetic reporter for in vivo visualization of chitin deposition in Drosophila. Sobala LF, et al. Development, 2015 Nov 15. PMID 26395478, Free PMC Article
  4. Dusky-like functions as a Rab11 effector for the deposition of cuticle during Drosophila bristle development. Nagaraj R, et al. Development, 2012 Mar. PMID 22278919, Free PMC Article
  5. Molecular analysis of the Drosophila miniature-dusky ( m-dy) gene complex: m-dy mRNAs encode transmembrane proteins with similarity to C. elegans cuticulin. DiBartolomeis SM, et al. Mol Genet Genomics, 2002 Jul. PMID 12172795

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that Dyl functions as a Rab11 effector for mediating the attachment of the bristle cell membrane to chitin to establish a stable cuticle.
    Title: Dusky-like functions as a Rab11 effector for the deposition of cuticle during Drosophila bristle development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of chitin-based cuticle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apical constriction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of embryonic cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dusky-like
Names
CG15013-PA
CG15013-PB
CG15013-PC
Dusky-like
dyl-PA
dyl-PB
dyl-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4294004..4307718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168078.2 → NP_728979.1  dusky-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728979.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZE0
    Related
    FBpp0073197
    Conserved Domains (2) summary
    smart00241
    Location:90 → 345
    ZP; Zona pellucida (ZP) domain
    PHA03378
    Location:339 → 494
    PHA03378; EBNA-3B; Provisional

  2. NM_139633.3 → NP_647890.2  dusky-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647890.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZE0
    Related
    FBpp0073198
    Conserved Domains (2) summary
    smart00241
    Location:90 → 345
    ZP; Zona pellucida (ZP) domain
    PHA03378
    Location:339 → 494
    PHA03378; EBNA-3B; Provisional

  3. NM_168079.2 → NP_728980.1  dusky-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728980.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZE0
    Related
    FBpp0073199
    Conserved Domains (2) summary
    smart00241
    Location:90 → 345
    ZP; Zona pellucida (ZP) domain
    PHA03378
    Location:339 → 494
    PHA03378; EBNA-3B; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q960I7 Q960I7
Q9VZE0 Q9VZE0

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