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    KRT3 keratin 3 [ Homo sapiens (human) ]

    Gene ID: 3850, updated on 5-May-2013
    Official Symbol
    KRT3provided by HGNC
    Official Full Name
    keratin 3provided by HGNC
    Primary source
    HGNC:6440
    See related
    Ensembl:ENSG00000186442; HPRD:01013; MIM:148043; Vega:OTTHUMG00000169799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K3; CK3
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
    Location :
    12q13.13
    Sequence :
    Chromosome: 12; NC_000012.11 (53183469..53189892, complement)
    See KRT3 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 2 binding protein pseudogene 2 Neighboring gene keratin 76 Neighboring gene keratin 4 Neighboring gene keratin 79

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    2. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    3. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    4. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Location of the E498V mutation emphasizes the functional relevance of the highly conserved boundary motifs at the COOH-terminus of the alpha-helical rod domain in keratin 3 (K3).
      Title: Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation.
    2. A novel missense mutation (R503P) in KRT3 leads to MCD in 2 unrelated Taiwanese families.
      Title: Novel mutations in the helix termination motif of keratin 3 and keratin 12 in 2 Taiwanese families with Meesmann corneal dystrophy.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:110048 BioGRID:107587 AP2M1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110048 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110048 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110048 BioGRID:107788 CRK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110048 BioGRID:113743 CUL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110048 BioGRID:108374 EPS15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110048 BioGRID:109433 HNRNPU    BioGRID  PubMed Co-fractionation 
    BioGRID:110048 BioGRID:119128 HP1BP3    BioGRID  PubMed Co-fractionation 
    BioGRID:110048 BioGRID:109848 INPPL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110048 BioGRID:109891 ITGAV    BioGRID  PubMed Co-fractionation 
    BioGRID:110048 BioGRID:110059 KRT14    BioGRID  PubMed Co-fractionation 
    BioGRID:110048 BioGRID:110050 KRT5    BioGRID  PubMed Co-fractionation 
    BioGRID:110048 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110048 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ95909

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    structural molecule activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		  
    epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    intermediate filament cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    intermediate filament NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    keratin filament TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Preferred Names
    keratin, type II cytoskeletal 3
    Names
    keratin, type II cytoskeletal 3
    CK-3
    cytokeratin 3
    cytokeratin-3
    65 kDa cytokeratin
    type-II keratin Kb3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008350.1 RefSeqGene

      Range
      5001..11424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057088.2 → NP_476429.2  keratin, type II cytoskeletal 3

      Status: REVIEWED

      Source sequence(s)
      AC107016, AJ628418, BM672628, CV571376
      Consensus CDS
      CCDS44895.1
      UniProtKB/Swiss-Prot
      P12035
      Related
      ENSP00000413479, OTTHUMP00000242121, ENST00000417996, OTTHUMT00000405930
      Conserved Domains (1) summary
      pfam00038
      Location:197 – 512
      Blast Score: 913
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p10 Primary Assembly

      Range
      53183469..53189892, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      50227434..50233858, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018923.1 Alternate CHM1_1.0

      Range
      53017874..53024318, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01008295.1 (100130..106554) None
    genomic AC107016.20 (175547..181889) None
    genomic AMYH01004474.1 (316544..322988) None
    genomic CH471054.1 EAW96645.1
      EAW96646.1
    genomic X05418.1 CAA28991.1
    genomic X05419.1 CAA28992.1
    genomic X05420.1 CAA28993.1
      CAA28994.1
      CAA28995.1
    genomic X05421.1 CAA28996.1
    mRNA AJ628418.1 CAF31522.1
    mRNA AK314987.1 None
    mRNA BM672628.1 None
    mRNA CV571376.1 None
    other-genetic BC156125.1 AAI56126.1
    other-genetic BC172453.1 AAI72453.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12035.3 GenPept UniProtKB/Swiss-Prot:P12035

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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