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KRT3 keratin 3, type II [ Homo sapiens (human) ]

Gene ID: 3850, updated on 26-Jun-2015
Official Symbol
KRT3provided by HGNC
Official Full Name
keratin 3, type IIprovided by HGNC
Primary source
HGNC:HGNC:6440
See related
Ensembl:ENSG00000186442; HPRD:01013; MIM:148043; Vega:OTTHUMG00000169799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K3; CK3
Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Orthologs
See KRT3 in Epigenomics, MapViewer
Location:
12q13.13
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (52789685..52805717, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53183469..53189892, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 2 binding protein pseudogene 2 Neighboring gene keratin 76, type II Neighboring gene keratin 4, type II Neighboring gene keratin 79, type II

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ95909

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
intermediate filament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
keratin filament TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
keratin, type II cytoskeletal 3
Names
keratin, type II cytoskeletal 3
65 kDa cytokeratin
CK-3
cytokeratin 3
cytokeratin-3
type-II keratin Kb3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008350.1 RefSeqGene

    Range
    5001..11424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057088.2NP_476429.2  keratin, type II cytoskeletal 3

    See identical proteins and their annotated locations for NP_476429.2

    Status: REVIEWED

    Source sequence(s)
    AC107016, AJ628418, BM672628, CV571376
    Consensus CDS
    CCDS44895.1
    UniProtKB/Swiss-Prot
    P12035
    Related
    ENSP00000413479, OTTHUMP00000242121, ENST00000417996, OTTHUMT00000405930
    Conserved Domains (2) summary
    pfam00038
    Location:197512
    Filament; Intermediate filament protein
    cl19113
    Location:382476
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    52789685..52805717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538324.1XP_011536626.1  

    Conserved Domains (2) summary
    pfam00038
    Location:77392
    Filament; Intermediate filament protein
    pfam10473
    Location:262356
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    53150250..53156694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)