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    IPO5 importin 5 [ Homo sapiens ]

    Gene ID: 3843, updated on 11-May-2012
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    Summary

    Official Symbol
    IPO5provided by HGNC
    Official Full Name
    importin 5provided by HGNC
    Primary source
    HGNC:6402
    Locus tag
    RP11-72J7.1
    See related
    Ensembl:ENSG00000065150; HPRD:03597; MIM:602008; Vega:OTTHUMG00000017244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IMB3; Pse1; imp5; KPNB3; RANBP5; MGC2068; FLJ43041; DKFZp686O1576
    Summary
    Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    13q32.2
    Sequence :
    Chromosome: 13; NC_000013.10 (98605929..98676550)
    See IPO5 in Epigenomics, MapViewer

    Chromosome 13 - NC_000013.10Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, alpha type, 6 pseudogene 4 Neighboring gene ribosomal protein L7a pseudogene 61 Neighboring gene uncharacterized LOC100652878 Neighboring gene ferritin, light polypeptide pseudogene 8 Neighboring gene FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) Neighboring gene ring finger protein 113B Neighboring gene microRNA 3170

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. Kang HC, et al. Proc Natl Acad Sci U S A, 2011 Aug 23. PMID 21825151.
    4. Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5. Hutchinson EC, et al. J Gen Virol, 2011 Aug. PMID 21562121.
    5. Purification and identification of endogenous polySUMO conjugates. Bruderer R, et al. EMBO Rep, 2011 Feb. PMID 21252943.

    See all (74) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The N-terminal of influenza A virus PB1 mediates its binding to host RanBP5.
      Title: Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5.
    2. The results of this study suggested that abnormal expression and alternative splicing of the IPO5 gene may be involved in the pathophysiology of schizophrenia.
      Title: Genetic and functional study of the IPO5 gene in schizophrenia.
    3. importin beta3 is essential for the nuclear import of RPL7. The import is mediated via the multifaceted basic amino acid clusters present in the NH(2)-region of RPL7, and is RanGTP-dependent
      Title: Importin β3 mediates the nuclear import of human ribosomal protein L7 through its interaction with the multifaceted basic clusters of L7.
    4. Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells.
      Title: Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells.
    5. These results suggest that karyopherin beta3 plays a crucial role in apo A-I secretion.
      Title: A novel function of karyopherin beta3 associated with apolipoprotein A-I secretion.
    6. Lack of association of the KPNB3 locus in schizophrenia.
      Title: Lack of association of the KPNB3 locus in case-control samples.
    7. HPV-16 E5 protein binds to karyopherin beta3.
      Title: Karyopherin beta3: a new cellular target for the HPV-16 E5 oncoprotein.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic and functional study of the IPO5 gene in schizophrenia.
    9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.
    10. The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia.
      Title: A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.
    Submit: New GeneRIF Correction See all (14)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Rev rev importin beta can inhibit the interaction of HIV-1 Rev with HIV-1 RRE RNA PubMed
    rev importin beta specifically binds to the Rev nuclear localization signal (NLS, amino acids 35-50) and mediates the nuclear import of Rev PubMed
    Tat tat The binding of HIV-1 Tat with importin beta is inhibited by RanGTP PubMed
    tat Importin beta binds to the HIV-1 Tat protein nuclear localization signal (NLS; amino acids 49-57) and mediates the nuclear import of Tat through a novel import pathway PubMed
    Vpr vpr HIV-1 Vpr co-localizes with karyopherin beta and regulates karyopherin beta-mediated docking of the HIV-1 preintegration complex at the nuclear envelope, however multiple reports indicate the two proteins do not directly interact PubMed
    integrase gag-pol Some reports indicate a possible role for the interactions between karyopherin alpha and beta with HIV-1 integrase in the nuclear import of HIV-1 preintegration complexes (PIC), while other reports indicate integrase is not involved in PIC nuclear import PubMed
    gag-pol Karyopherin beta binds to complexes between HIV-1 integrase (integrase/GST fusion protein) and karyopherin alpha, but not to integrase alone PubMed
    gag-pol Karyopherin alpha and beta are reported to interact with HIV-1 integrase (IN) to facilitate nuclear import of IN, however a conflicting report indicates nuclear accumulation of IN does not involve karyopherin alpha, beta 1, or beta 2 mediated pathways PubMed
    matrix gag Karyopherin beta mediates the nuclear import of HIV-1 preintegration complexes through karyopherin alpha, which binds directly to nuclear localization signals in HIV-1 Matrix PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002262.3 NP_751927.1 HCVgp1    BIND  PubMed Hepatitis C virus (HCV) nonstructural protein 5A interacts with karyopherin beta 3. 
    O00410 Basic helix-loop-helix domain containing, class B, 9 BHLHB9    HPRD  PubMed  
    O00410 Q6W0C5 DPPA3    HPRD  PubMed  
    O00410 P07305 H1F0    HPRD  PubMed  
    O00410 P49790 NUP153    HPRD  PubMed  
    O00410 P35658 NUP214    HPRD  PubMed  
    O00410 P37198 NUP62    HPRD  PubMed  
    O00410 P52948 NUP98    HPRD  PubMed  
    O00410 P55895 RAG2    HPRD  PubMed  
    O00410 P62826 RAN    HPRD  PubMed  
    O00410 P49792 RANBP2    HPRD  PubMed  
    O00410 P26373 RPL13    HPRD  PubMed  
    O00410 P62829 RPL23    HPRD  PubMed  
    O00410 P62750 RPL23A    HPRD  PubMed  
    O00410 P46777 RPL5    HPRD  PubMed  
    O00410 P62081 RPS7    HPRD  PubMed  
    BioGRID:110041 BioGRID:198290 Azi1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:113911 BAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:123857 DTNBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:110041 BioGRID:116465 GABARAP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:117223 GABARAPL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:116473 GABARAPL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:110763 NBN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:115297 NUP153    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110041 BioGRID:113717 NUP214    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110041 BioGRID:203509 Nhp2l1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:111391 PMS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110041 BioGRID:111837 RAN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110041 BioGRID:123598 RNF146    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:112067 RPL23A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110041 BioGRID:112606 SRP19    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110041 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:122548 TAF1D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110041 BioGRID:131884 USP50    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the IPO5 gene: The IPO5 gene is conserved in chimpanzee, , dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Influenza Infection, organism-specific biosystem (from REACTOME)
      Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
    • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
      Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
    • Influenza Viral RNA Transcription and Replication, organism-specific biosystem (from REACTOME)
      Influenza Viral RNA Transcription and Replication, organism-specific biosystemIn the host cell nucleus, the viral negative-strand RNA (vRNA) serves as a template for the synthesis both of capped, polyadenylated viral messenger RNA and of full-length positive-strand RNA or comp...
    • vRNP Assembly, organism-specific biosystem (from REACTOME)
      vRNP Assembly, organism-specific biosystemFor each of eight gene segments, a viral ribonucleoprotein (vRNP), containing a viral negative-sense RNA (vRNA) segment complexed with nucleoprotein (NP) and the trimeric influenza polymerase (PB1, P...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Ran GTPase binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NLS-bearing substrate import into nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    ribosomal protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear pore TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    importin-5
    Names
    importin-5
    karyopherin beta-3
    RAN binding protein 5
    ran-binding protein 5
    importin beta-3 subunit
    importin subunit beta-3
    Ran_GTP binding protein 5
    karyopherin (importin) beta 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002271.4 → NP_002262.3  importin-5

      Status: REVIEWED

      Source sequence(s)
      AF339834, AK125031, AL705630, BC000947, BC001497, BC045640, BM666295, BU618294, Y08890
      Consensus CDS
      CCDS31999.1
      UniProtKB/TrEMBL
      B3KWG6
      UniProtKB/Swiss-Prot
      O00410
      UniProtKB/TrEMBL
      Q9BVS9
      Related
      ENSP00000261574, OTTHUMP00000018583, ENST00000261574, OTTHUMT00000045533
      Conserved Domains (3) summary
      COG5215
      Location:31 – 652
      Blast Score: 180
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      pfam12755
      Location:392 – 440
      Blast Score: 102
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      pfam13513
      Location:937 – 997
      Blast Score: 94
      HEAT_EZ; HEAT-like repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000013.10 Reference GRCh37.p5 Primary Assembly

      Range
      98605929..98676550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000145.1 Alternate HuRef

      Range
      79203817..79274125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL137120.13 CAI16520.1
    genomic AL356580.13 CAI13757.1
      CAI13758.1
      CAI13759.1
    genomic CH471085.1 EAX08977.1
      EAX08978.1
      EAX08979.1
      EAX08980.1
      EAX08981.1
    mRNA AF339834.1 None
    mRNA AK125031.1 BAG54128.1
    mRNA AK225286.1 None
    mRNA AK302812.1 BAG64012.1
    mRNA AK303494.1 BAG64528.1
    mRNA AL705630.1 None
    mRNA BC000947.2 AAH00947.1
    mRNA BC001497.2 AAH01497.1
    mRNA BC019309.1 AAH19309.1
    mRNA BC045640.1 AAH45640.1
    mRNA BM666295.1 None
    mRNA BU618294.1 None
    mRNA BX648222.1 None
    mRNA U72761.1 AAC51317.1
    mRNA Y08890.1 CAA70103.1
    other-genetic DQ893033.2 ABM83959.1
    other-genetic EU176755.1 ABW03556.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00410.4 GenPept UniProtKB/Swiss-Prot:O00410
    Q5T576 GenPept UniProtKB/TrEMBL:Q5T576
    Q5T577 GenPept UniProtKB/TrEMBL:Q5T577
    Q9BVS9 GenPept UniProtKB/TrEMBL:Q9BVS9
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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