KPNA5 karyopherin alpha 5 (importin alpha 6) [Homo sapiens] - Gene

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Summary

Official Symbol: KPNA5provided by HGNC
Official Full Name: karyopherin alpha 5 (importin alpha 6)provided by HGNC
Primary source: HGNC:6398
Locus tag: RP3-412I7.4
See related: Ensembl:ENSG00000196911; HPRD:05179; MIM:604545; Vega:OTTHUMG00000015448
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SRP6; IPOA6
Summary: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 6q22.1

Sequence :: Chromosome: 6; NC_000006.11 (117002367..117063030)

See KPNA5 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study identified the sequences KKKRR, KKKRK, and KKRKK as the optimal sequences for binding to this site for mouse importin-alpha2, human importin-alpha1, and human importin-alpha5, respectively.
Title: Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
integrase	gag-pol	Some reports indicate a possible role for the interactions between karyopherin alpha and beta with HIV-1 integrase in the nuclear import of HIV-1 preintegration complexes (PIC), while other reports indicate integrase is not involved in PIC nuclear import	PubMed
	gag-pol	Karyopherin alpha binds to a bipartite nuclear localization signal in HIV-1 integrase (amino acids 186-189 and 211-219)	PubMed
	gag-pol	Karyopherin alpha and beta are reported to interact with HIV-1 integrase (IN) to facilitate nuclear import of IN, however a conflicting report indicates nuclear accumulation of IN does not involve karyopherin alpha, beta 1, or beta 2 mediated pathways	PubMed
matrix	gag	Nuclear import of HIV-1 preintegration complexes by karyopherin alpha is governed by phosphorylation of HIV-1 Matrix on tyrosine and serine, however the exact role of phosphorylation of the C-terminal tyrosine of Matrix has been debated	PubMed
	gag	HIV-1 Matrix increases intracellular ATP content, an effect hypothesized to support the ATP-dependent nuclear import of HIV-1 preintegration complexes by karyopherin alpha	PubMed
	gag	HIV-1 Vpr increases the affinity of karyopherin alpha to the HIV-1 Matrix nuclear localization signal, thereby mediating the nuclear import of HIV-1 preintegration complexes	PubMed
	gag	Hsp70 stimulates the binding of HIV-1 matrix to karyopherin alpha	PubMed
	gag	The role of HIV-1 Matrix during nuclear import of the HIV-1 preintegration complex has been controversial, however recent understanding indicates HIV-1 Matrix and Vpr proteins act in concert to facilitate nuclear import by binding to karyopherin alpha	PubMed
	gag	HIV-1 Matrix contains two nuclear localization signals (NLS) spanning amino acids 24-33 and 110-114 that are recognized by karyopherin alpha and mediate the nuclear import of HIV-1 preintegration complexes	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
O15131	P39687	ANP32A	HPRD	PubMed
O15131	Q9HCU9	BRMS1	HPRD	PubMed
O15131	P46527	CDKN1B	HPRD	PubMed
BioGRID:110039	BioGRID:107533	CHD4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110039	BioGRID:121122	MEPCE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110039	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NLS-bearing substrate import into nucleus	TAS Traceable Author Statement more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
protein import into nucleus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: importin subunit alpha-6

Names: importin subunit alpha-6; importin alpha 6; karyopherin subunit alpha-5

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002269.2 → NP_002260.2 importin subunit alpha-6

Status: REVIEWED

Source sequence(s)

AA332147, BC047409, BG721781

Consensus CDS

CCDS5111.1

UniProtKB/Swiss-Prot

O15131

Related

ENSP00000348704, ENST00000356348

Conserved Domains (3) summary

cd00020
Location:254 – 368
Blast Score: 266

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

COG5064
Location:12 – 521
Blast Score: 1459

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

pfam01749
Location:5 – 97
Blast Score: 331

IBB; Importin beta binding domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

117002367..117063030

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

114581937..114642615

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL132795.12	CAI20500.1
		CAI20501.1
		CAI20502.1
genomic	AL354716.9 (100..387)	None
genomic	CH471051.2	EAW48216.1
mRNA	AA332147.1	None
mRNA	AF005361.1	AAC51868.1
mRNA	AK314206.1	BAG36882.1
mRNA	BC047409.1	AAH47409.1
mRNA	BG721781.1	None
other-genetic	HQ447973.1	ADQ32456.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O15131.2	GenPept	UniProtKB/Swiss-Prot:O15131
Q5TD89	GenPept	UniProtKB/TrEMBL:Q5TD89
Q5TD90	GenPept	UniProtKB/TrEMBL:Q5TD90