KPNA3 karyopherin alpha 3 (importin alpha 4) [Homo sapiens] - Gene

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Summary

Official Symbol: KPNA3provided by HGNC
Official Full Name: karyopherin alpha 3 (importin alpha 4)provided by HGNC
Primary source: HGNC:6396
Locus tag: RP11-432M24.3
See related: Ensembl:ENSG00000102753; HPRD:03536; MIM:601892; Vega:OTTHUMG00000016922
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SRP1; SRP4; IPOA4; hSRP1; SRP1gamma
Summary: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]

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Genomic context

Location :: 13q14.3

Sequence :: Chromosome: 13; NC_000013.10 (50273443..50367057, complement)

See KPNA3 in Epigenomics, MapViewer

Chromosome 13 - NC_000013.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.
The present study suggests that the KPNA3 may contribute genetically to schizophrenia in a small effect size.
Title: The KPNA3 gene may be a susceptibility candidate for schizophrenia.
The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia.
Title: A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
integrase	gag-pol	Karyopherin alpha binds to a bipartite nuclear localization signal in HIV-1 integrase (amino acids 186-189 and 211-219)	PubMed
	gag-pol	Some reports indicate a possible role for the interactions between karyopherin alpha and beta with HIV-1 integrase in the nuclear import of HIV-1 preintegration complexes (PIC), while other reports indicate integrase is not involved in PIC nuclear import	PubMed
	gag-pol	Karyopherin alpha and beta are reported to interact with HIV-1 integrase (IN) to facilitate nuclear import of IN, however a conflicting report indicates nuclear accumulation of IN does not involve karyopherin alpha, beta 1, or beta 2 mediated pathways	PubMed
matrix	gag	Nuclear import of HIV-1 preintegration complexes by karyopherin alpha is governed by phosphorylation of HIV-1 Matrix on tyrosine and serine, however the exact role of phosphorylation of the C-terminal tyrosine of Matrix has been debated	PubMed
	gag	The role of HIV-1 Matrix during nuclear import of the HIV-1 preintegration complex has been controversial, however recent understanding indicates HIV-1 Matrix and Vpr proteins act in concert to facilitate nuclear import by binding to karyopherin alpha	PubMed
	gag	HIV-1 Matrix increases intracellular ATP content, an effect hypothesized to support the ATP-dependent nuclear import of HIV-1 preintegration complexes by karyopherin alpha	PubMed
	gag	HIV-1 Vpr increases the affinity of karyopherin alpha to the HIV-1 Matrix nuclear localization signal, thereby mediating the nuclear import of HIV-1 preintegration complexes	PubMed
	gag	Hsp70 stimulates the binding of HIV-1 matrix to karyopherin alpha	PubMed
	gag	HIV-1 Matrix contains two nuclear localization signals (NLS) spanning amino acids 24-33 and 110-114 that are recognized by karyopherin alpha and mediate the nuclear import of HIV-1 preintegration complexes	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
O00505	P46527	CDKN1B	HPRD	PubMed
O00505	P38432	COIL	HPRD	PubMed
O00505	Q9Y247	FAM50B	HPRD	PubMed
O00505	Q14974	KPNB1	HPRD	PubMed
O00505	P19838	NFKB1	HPRD	PubMed
O00505	P18754	RCC1	HPRD	PubMed
O00505	P21980	TGM2	HPRD	PubMed
BioGRID:110037	BioGRID:106901	ARRB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110037	BioGRID:106902	ARRB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110037	BioGRID:117631	FAM50B	BioGRID	PubMed	Two-hybrid
BioGRID:110037	BioGRID:109424	HNRNPC	BioGRID	PubMed	Two-hybrid
BioGRID:110037	BioGRID:110035	KPNB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110037	BioGRID:121122	MEPCE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110037	BioGRID:201430	Mki67	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110037	BioGRID:110857	NFKB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110037	BioGRID:107529	RCC1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110037	BioGRID:202582	Ranbp2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110037	BioGRID:116983	SIRT1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110037	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110037	BioGRID:123904	USP42	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
nuclear localization sequence binding	TAS Traceable Author Statement more info	PubMed
protein C-terminus binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NLS-bearing substrate import into nucleus	TAS Traceable Author Statement more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
interspecies interaction between organisms	IEA Inferred from Electronic Annotation more info
protein complex assembly	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
nuclear pore	TAS Traceable Author Statement more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: importin subunit alpha-3

Names: importin subunit alpha-3; qip2; SRP1-gamma; importin alpha 4; importin alpha-3; importin alpha Q2; importin-alpha-Q2; karyopherin subunit alpha-3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002267.3 → NP_002258.2 importin subunit alpha-3

Status: REVIEWED

Source sequence(s)

AI309735, AK291000, AU132188, BC035090, DN991804

Consensus CDS

CCDS9421.1

UniProtKB/Swiss-Prot

O00505

UniProtKB/TrEMBL

Q8IYQ9

Related

ENSP00000261667, OTTHUMP00000018426, ENST00000261667, OTTHUMT00000044939

Conserved Domains (3) summary

cd00020
Location:242 – 355
Blast Score: 267

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

COG5064
Location:2 – 515
Blast Score: 1259

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

pfam01749
Location:3 – 94
Blast Score: 300

IBB; Importin beta binding domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000013.10 Reference GRCh37.p5 Primary Assembly

Range

50273443..50367057, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000145.1 Alternate HuRef

Range

31066776..31160103, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL135901.23	CAI40716.1
		CAI40722.1
genomic	AL136301.21	CAH71145.1
genomic	CH471075.1	EAX08837.1
		EAX08838.1
		EAX08839.1
mRNA	AF005263.1	AAQ13404.1
mRNA	AF034756.1	AAB87693.1
mRNA	AI309735.1	None
mRNA	AK223480.1	BAD97200.1
mRNA	AK290528.1	BAF83217.1
mRNA	AK291000.1	BAF83689.1
mRNA	AU132188.1	None
mRNA	BC017355.2	AAH17355.1
mRNA	BC024202.2	AAH24202.1
mRNA	BC035090.2	AAH35090.1
mRNA	D89618.1	BAA20378.1
mRNA	DN991804.1	None
mRNA	Y12394.1	CAA73026.1
other-genetic	DQ892644.2	ABM83570.1
other-genetic	DQ895882.2	ABM86808.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O00505.2	GenPept	UniProtKB/Swiss-Prot:O00505
Q53F09	GenPept	UniProtKB/TrEMBL:Q53F09
Q5JVN1	GenPept	UniProtKB/TrEMBL:Q5JVN1
Q8IYQ9	GenPept	UniProtKB/TrEMBL:Q8IYQ9