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    Hsp83 Heat shock protein 83 [ Drosophila melanogaster ]

    Gene ID: 38389, updated on 19-May-2012
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    Summary

    Official Symbol
    Hsp83provided by Flybase
    Official Full Name
    Heat shock protein 83provided by Flybase
    Primary source
    FLYBASE:FBgn0001233
    Locus tag
    Dmel_CG1242
    Gene type
    protein coding
    RNA name
    heat shock protein 83
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    143198_at; 83; 83K HSP; anon-EST:Liang-2.53; anon-WO0068693; anon-WO0140519.209; CG1242; clone 2.53; Dmel\CG1242; DMHSP82; E(sev)3A; E(sina)2; en(lz)3C/4C; hsp82; Hsp82; HSP82; hsp83; HSP83; hsp84; hsp90; Hsp90; HSP90; l(3)j5C2; ms(3)08445; ORF1; stc; Su(Raf)3A
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    Genomic context

    Location :
    63B11-63B11; 3-5 cM
    Sequence :
    Chromosome: 3L; NT_037436.3 (3193027..3197059)
    See Hsp83 in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene CG14957 gene product from transcript CG14957-RA Neighboring gene CG42525 gene product from transcript CG42525-RA Neighboring gene CG14958 gene product from transcript CG14958-RA Neighboring gene CG14965 gene product from transcript CG14965-RA Neighboring gene CG14966 gene product from transcript CG14966-RA Neighboring gene CG32276 gene product from transcript CG32276-RC Neighboring gene gryzun Neighboring gene CG32271 gene product from transcript CG32271-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. Weake VM, et al. Genes Dev, 2011 Jul 15. PMID 21764853.
    3. The Rho-family GTPase Rac1 regulates integrin localization in Drosophila immunosurveillance cells. Xavier MJ, et al. PLoS One, 2011. PMID 21603603.
    4. Physical assessment of toxicology at nanoscale: nano dose-metrics and toxicity factor. Pompa PP, et al. Nanoscale, 2011 Jul. PMID 21547322.
    5. Environmental stress-dependent effects of deletions encompassing Hsp70Ba on canalization and quantitative trait asymmetry in Drosophila melanogaster. Takahashi KH, et al. PLoS One, 2011 Apr 25. PMID 21541022.

    See all (261) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Piwi functions in Hsp90-mediated suppression of phenotypic variation
      Title: Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation.
    2. A natural genetic variation in Hsp90 may mediate the evolution of canalized morphological traits even if it does not influence the expression of variation for uncanalized traits.
      Title: A naturally occurring variant of Hsp90 that is associated with decanalization.
    3. Hsp90 is required for Ago2 to receive the small interfering RNA (siRNA) duplex from the RNA-induced silencing complex-loading complex in RNA interference.
      Title: A direct role for Hsp90 in pre-RISC formation in Drosophila.
    4. Up to 120-fold differences in penetrance among six highly related selection lines, selected for and against a deformed eye trait, did not translate into measurable differences in viability, lifespan or competitive fitness.
      Title: Modularity and intrinsic evolvability of Hsp90-buffered change.
    5. To determine the effect of Hsp90 on quantitative trait variability we deconstructed genetic, stochastic and environmental components of variation in traits of genetically matched flies, differing only by Hsp90 loss-of-function or wild-type alleles.
      Title: Control of canalization and evolvability by Hsp90.
    6. Hsp83 mutations can generate new variation by transposon-mediated 'canonical' mutagenesis
      Title: Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons.
    7. Life span alteration after irradiation in Drosophila melanogaster strains with mutations of Hsf and Hsps.
      Title: Life span alteration after irradiation in Drosophila melanogaster strains with mutations of Hsf and Hsps.
    8. These findings suggest that Sgt1 is involved in the stabilization of Polo allowing normal centrosome maturation, entry and progression though mitosis.
      Title: Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization.
    9. Hsp90 interacts in vitro with the translational repressor Cup.
      Title: The molecular chaperone Hsp90 is a component of the cap-binding complex and interacts with the translational repressor Cup during Drosophila oogenesis.
    10. Hsp90 cooperates with Trx at chromatin for maintaining the active expression state of targets like the Hox genes.
      Title: Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression.
    Submit: New GeneRIF Correction See all (14)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:63886 BioGRID:68655 ATPsyn-beta    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:59312 AnnX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:65734 Arf79F    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:63355 CG12491    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:66384 CG12811    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:62970 CG13423    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:59255 CG14207    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:59284 CG14235    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:72680 CG15308    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:70901 CG16833    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:61182 CG17568    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:61582 CG2064    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:68613 CG31999    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:59869 CG3225    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:58683 CG32635    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:64510 CG3335    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:65149 CG4169    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:66534 CG6830    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:59065 CG8316    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:72161 Ca-P60A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:58885 Chc    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:63970 Chd64    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:66325 Crc    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:61363 Df31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:61464 Dpit47    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:60941 Gli    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:68235 Gp93    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:59458 Hop    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:62181 Nacalpha    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:68416 Nlp    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:68313 Vha100-1    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:63229 blw    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:62418 chn    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:59586 cpb    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:65132 fax    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:58331 lz    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:63886 BioGRID:62356 phyl    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:60572 porin    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:58570 regucalcin    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63886 BioGRID:67796 sec10    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:65183 sina    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:63886 BioGRID:68746 spag    BioGRID  PubMed Two-hybrid 
    BioGRID:63886 BioGRID:61589 tor    BioGRID  PubMed Phenotypic Suppression 
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    General gene information

    Homology

    • Homologs of the Hsp83 gene: The Hsp83 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, A.thaliana, rice, and P.falciparum.

    Pathways from BioSystems

    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATPase activity, coupled ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    R7 cell fate commitment TAS
    Traceable Author Statement
    more info
    		  
    actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    anterior/posterior axis specification, embryo TAS
    Traceable Author Statement
    more info
    		 PubMed 
    centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    oogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    pole plasm mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of circadian sleep/wake cycle, sleep TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    torso signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    		  
    lipid particle IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    CG1242 gene product from transcript CG1242-RA
    Names
    CG1242-PA
    Hsp83-PA
    enhancer of seven in absentia 2
    enhancer of sevenless 3A
    heat shock protein 83
    scratch
    NP_523899.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      3193027..3197059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079175.3 → NP_523899.1  heat shock protein 83 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02828
      Related
      FBpp0072904
      Conserved Domains (2) summary
      cd00075
      Location:30 – 143
      Blast Score: 103
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      PTZ00272
      Location:6 – 717
      Blast Score: 2104
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic X03810.1 CAA27435.1
    genomic AE014296.4 AAF47734.1
    genomic AX047373.1 CAC18966.1
    mRNA AY122080.1 AAM52592.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    A24827.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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