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    MEP-1 [ Drosophila melanogaster ]

    Gene ID: 38327, updated on 10-May-2012
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    Summary

    Official Symbol
    MEP-1provided by Flybase
    Primary source
    FLYBASE:FBgn0035357
    Locus tag
    Dmel_CG1244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.37; anon-WO0118547.584; CG1244; clone 1.37; Dmel\CG1244; dMEP-1; MEP1
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    Genomic context

    Location :
    62E8-62E8
    Sequence :
    Chromosome: 3L; NT_037436.3 (2631720..2641977)
    See MEP-1 in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene CG12182 gene product from transcript CG12182-RA Neighboring gene CG16985 gene product from transcript CG16985-RA Neighboring gene CG16986 gene product from transcript CG16986-RA Neighboring gene Peroxidasin Neighboring gene CG42245 gene product from transcript CG42245-RA Neighboring gene CG14949 gene product from transcript CG14949-RA Neighboring gene CG1143 gene product from transcript CG1143-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Reddy BA, et al. Mol Cell Biol, 2010 Nov. PMID 20733004.
    2. Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Gan Q, et al. Cell Res, 2010 Jul. PMID 20440302.
    3. A novel role of the glial fate determinant glial cells missing in hematopoiesis. Jacques C, et al. Int J Dev Biol, 2009. PMID 19598118.
    4. dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repression. Kunert N, et al. EMBO J, 2009 Mar 4. PMID 19165147.
    5. Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen. Stielow B, et al. Mol Cell, 2008 Mar 28. PMID 18374648.

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Genomewide expression analysis established that TTK69, MEP1, and Mi2 cooperate closely to control transcription.
      Title: Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:63832 BioGRID:58604 CG11138    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:61365 Cul-2    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:59275 Mer    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:64238 Neos    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:58080 Pat1    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:59273 Ubqn    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:59522 aru    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:66618 lig3    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:62946 mus209    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:64424 orb2    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:77545 p53    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:61701 ptc    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:57584 skpA    BioGRID  PubMed Two-hybrid 
    BioGRID:63832 BioGRID:68433 spn-A    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to nucleosome-dependent ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NuRD complex IPI
    Inferred from Physical Interaction
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    CG1244 gene product from transcript CG1244-RG
    Names
    CG1244-PA
    CG1244-PB
    CG1244-PC
    CG1244-PD
    CG1244-PE
    CG1244-PF
    CG1244-PG
    MEP-1
    MEP-1-PA
    MEP-1-PB
    MEP-1-PC
    MEP-1-PD
    MEP-1-PE
    MEP-1-PF
    MEP-1-PG
    NP_001137875.1
    NP_647733.1
    NP_728761.1
    NP_728762.1
    NP_728763.1
    NP_728764.1
    NP_728765.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      2631720..2641977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144403.1 → NP_001137875.1  MEP-1, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0
      Related
      FBpp0288779, FBtr0290340

    2. NM_167959.1 → NP_728762.1  MEP-1, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0
      Related
      FBpp0072808, FBtr0072931

    3. NM_139476.2 → NP_647733.1  MEP-1, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0
      Related
      FBpp0072809, FBtr0072932

    4. NM_167958.1 → NP_728761.1  MEP-1, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0
      Related
      FBpp0072810, FBtr0072933

    5. NM_167960.1 → NP_728763.1  MEP-1, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0
      Related
      FBpp0072811, FBtr0072934

    6. NM_167962.1 → NP_728765.1  MEP-1, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0
      Related
      FBpp0072812, FBtr0072935

    7. NM_167961.1 → NP_728764.1  MEP-1, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8J0
      Related
      FBpp0072813, FBtr0072936
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014296.4 AAN11519.1
    genomic AE014296.4 AAG22230.1
    genomic AE014296.4 AAF47670.1
    genomic AE014296.4 AAG22231.1
    genomic AE014296.4 AAF47669.1
    genomic AE014296.4 AAN11520.1
    genomic AE014296.4 ACL83231.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZZ3.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content