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KLC1 kinesin light chain 1 [ Homo sapiens (human) ]

Gene ID: 3831, updated on 12-May-2016
Official Symbol
KLC1provided by HGNC
Official Full Name
kinesin light chain 1provided by HGNC
Primary source
HGNC:HGNC:6387
See related
Ensembl:ENSG00000126214 HPRD:02489; MIM:600025; Vega:OTTHUMG00000169227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLC; KNS2; KNS2A
Summary
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]
Orthologs
Location:
14q32.3
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (103629188..103701551)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104095525..104167888)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene apoptogenic 1, mitochondrial Neighboring gene uncharacterized LOC105370688 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene zinc finger FYVE-type containing 21 Neighboring gene protein phosphatase 1 regulatory subunit 13B Neighboring gene long intergenic non-protein coding RNA 637

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 trafficking events, organism-specific biosystem
    Arf6 trafficking events
  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases activate KTN1, organism-specific biosystem (from REACTOME)
    RHO GTPases activate KTN1, organism-specific biosystemGTP-bound active forms of RHO GTPases RHOA, RHOG, RAC1 and CDC42 bind kinectin (KTN1), a protein inserted in endoplasmic reticulum membranes that interacts with the cargo-binding site of kinesin and ...
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: APOPT1

Homology

Clone Names

  • MGC15245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
motor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
microtubule-based movement TAS
Traceable Author Statement
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
stress granule disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic, membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
kinesin complex ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
kinesin light chain 1
Names
kinesin 2 60/70kDa
medulloblastoma antigen MU-MB-2.50

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012307.1 RefSeqGene

    Range
    5001..77364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130107.1NP_001123579.1  kinesin light chain 1 isoform 3

    See identical proteins and their annotated locations for NP_001123579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3, also known as D.
    Source sequence(s)
    BC008881, BK001163, BK001164, BM988840, BP274336
    Consensus CDS
    CCDS45168.1
    UniProtKB/Swiss-Prot
    Q07866
    UniProtKB/TrEMBL
    Q7RTQ2
    Related
    ENSP00000414982, OTTHUMP00000240457, ENST00000452929, OTTHUMT00000402950
    Conserved Domains (5) summary
    pfam09311
    Location:80254
    Rab5-bind; Rabaptin-like protein
    pfam13374
    Location:296337
    TPR_10; Tetratricopeptide repeat
    pfam13414
    Location:253328
    TPR_11; TPR repeat
    pfam13424
    Location:293370
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
  2. NM_005552.4NP_005543.2  kinesin light chain 1 isoform 1

    See identical proteins and their annotated locations for NP_005543.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 3' sequence, as compared to variant 3. The resulting isoform (1, also known as C) has a shorter and distinct C-terminus, as compared to isoform 3.
    Source sequence(s)
    AL049840, BC008881, BP274336, CB050619, DA501532
    Consensus CDS
    CCDS32165.1
    UniProtKB/Swiss-Prot
    Q07866
    Related
    ENSP00000374394, OTTHUMP00000240452, ENST00000389744, OTTHUMT00000402945
    Conserved Domains (5) summary
    pfam09311
    Location:80254
    Rab5-bind; Rabaptin-like protein
    pfam13374
    Location:296337
    TPR_10; Tetratricopeptide repeat
    pfam13414
    Location:253328
    TPR_11; TPR repeat
    pfam13424
    Location:293370
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
  3. NM_182923.3NP_891553.2  kinesin light chain 1 isoform 2

    See identical proteins and their annotated locations for NP_891553.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 3. The resulting isoform (2, also known as H) has a shorter and distinct C-terminus when compared to isoform 3.
    Source sequence(s)
    AL139300, BM988840, BP274336, L04733
    Consensus CDS
    CCDS41996.1
    UniProtKB/Swiss-Prot
    Q07866
    Related
    ENSP00000341154, OTTHUMP00000240454, ENST00000348520, OTTHUMT00000402947
    Conserved Domains (5) summary
    pfam09311
    Location:80254
    Rab5-bind; Rabaptin-like protein
    pfam13374
    Location:296337
    TPR_10; Tetratricopeptide repeat
    pfam13414
    Location:253328
    TPR_11; TPR repeat
    pfam13424
    Location:293370
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    103629188..103701551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    104033686..104106029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)