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    metl methyltransferase-like [ Drosophila melanogaster ]

    Gene ID: 38197, updated on 9-May-2012
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    Summary

    Official Symbol
    metlprovided by Flybase
    Official Full Name
    methyltransferase-likeprovided by Flybase
    Primary source
    FLYBASE:FBgn0035247
    Locus tag
    Dmel_CG13929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey109; CG13929; Dmel\CG13929
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    Genomic context

    Location :
    62A9-62A9
    Sequence :
    Chromosome: 3L; NT_037436.3 (1637942..1639234, complement)
    See metl in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene gamma-glutamyl carboxylase Neighboring gene CG13928 gene product from transcript CG13928-RA Neighboring gene n-synaptobrevin Neighboring gene alpha-coatomer protein Neighboring gene Big brother

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    3. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.
    4. Combined evidence annotation of transposable elements in genome sequences. Quesneville H, et al. PLoS Comput Biol, 2005 Jul. PMID 16110336.
    5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208.

    See all (11) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_647636.3 NP_524184.1 Psn    BIND  PubMed Presenilin (DLA-b) interacts with Metl. 
    NP_647636.3 NP_730535.1 Psn    BIND  PubMed Presenilin (DLA-a) interacts with Metl. 
    BioGRID:63731 BioGRID:67579 CG7069    BioGRID  PubMed Two-hybrid 
    BioGRID:63731 BioGRID:59568 Cdlc2    BioGRID  PubMed Two-hybrid 
    BioGRID:63731 BioGRID:67217 Dlc90F    BioGRID  PubMed Two-hybrid 
    BioGRID:63731 BioGRID:58460 Hsp60    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63731 BioGRID:65518 Psn    BioGRID  PubMed Phenotypic Enhancement; Reconstituted Complex; Two-hybrid 
    BioGRID:63731 BioGRID:57853 Rala    BioGRID  PubMed Two-hybrid 
    BioGRID:63731 BioGRID:57920 ctp    BioGRID  PubMed Two-hybrid 
    BioGRID:63731 BioGRID:58261 oc    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the metl gene: The metl gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , and N.crassa.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    S-adenosylmethionine-dependent methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
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    General protein information

    Preferred Names
    CG13929 gene product from transcript CG13929-RA
    Names
    CG13929-PA
    CG13929-PB
    methyltransferase-like
    metl-PA
    metl-PB
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      1637942..1639234, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167907.2 → NP_728647.2  methyltransferase-like, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB75
      UniProtKB/Swiss-Prot
      Q86BS6
      Related
      FBpp0072695, FBtr0072813
      Conserved Domains (2) summary
      cd02440
      Location:113 – 219
      Blast Score: 165
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam13847
      Location:112 – 267
      Blast Score: 125
      Methyltransf_31; Methyltransferase domain

    2. NM_139379.3 → NP_647636.3  methyltransferase-like, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86BS6
      Related
      FBpp0072696, FBtr0072814
      Conserved Domains (2) summary
      cd02440
      Location:136 – 242
      Blast Score: 168
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam13847
      Location:135 – 290
      Blast Score: 129
      Methyltransf_31; Methyltransferase domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA BT126162.1 ADZ99414.1
    genomic AE014296.4 AAF47532.2
    genomic AE014296.4 AAF47531.2
    mRNA AY051875.1 AAK93299.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BS6.2 GenPept
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    Additional Links

    Gene LinkOut

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