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    KISS1 KiSS-1 metastasis-suppressor [ Homo sapiens ]

    Gene ID: 3814, updated on 20-May-2012
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    Summary

    Official Symbol
    KISS1provided by HGNC
    Official Full Name
    KiSS-1 metastasis-suppressorprovided by HGNC
    Primary source
    HGNC:6341
    Locus tag
    PP5098
    See related
    Ensembl:ENSG00000170498; HPRD:04475; MIM:603286; Vega:OTTHUMG00000036060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KiSS-1; MGC39258
    Summary
    This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
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    Genomic context

    Location :
    1q32
    Sequence :
    Chromosome: 1; NC_000001.10 (204159469..204165619, complement)
    See KISS1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene ethanolamine kinase 2 Neighboring gene renin Neighboring gene tripartite motif containing 60 pseudogene Neighboring gene golgi transport 1A Neighboring gene pleckstrin homology domain containing, family A member 6 Neighboring gene uncharacterized LOC100506823

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Inactivating KISS1 mutation and hypogonadotropic hypogonadism. Topaloglu AK, et al. N Engl J Med, 2012 Feb 16. PMID 22335740.
    2. KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion. Porzionato A, et al. Eur J Histochem, 2011 May 4. PMID 22193294.
    3. Inotropic action of the puberty hormone kisspeptin in rat, mouse and human: cardiovascular distribution and characteristics of the kisspeptin receptor. Maguire JJ, et al. PLoS One, 2011. PMID 22132116.
    4. Clinical significance of KISS1 protein expression for brain invasion and metastasis. Ulasov IV, et al. Cancer, 2012 Apr 15. PMID 21928364.
    5. GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1. Chan YM, et al. J Clin Endocrinol Metab, 2011 Nov. PMID 21880801.

    See all (113) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. we observed a significant correlation between expression of KISS1 and metastasis-free survival (P = .04) along with progression of breast cancer and expression of KISS1 in primary breast cancer
      Title: Clinical significance of KISS1 protein expression for brain invasion and metastasis.
    2. Kisspeptin and its receptor are expressed in the human, rat and mouse heart and kisspeptins possess potent positive inotropic activity.
      Title: Inotropic action of the puberty hormone kisspeptin in rat, mouse and human: cardiovascular distribution and characteristics of the kisspeptin receptor.
    3. KISS1 methylation and its expression may have a role in poor survival in bladder neoplasms
      Title: KISS1 methylation and expression as tumor stratification biomarkers and clinical outcome prognosticators for bladder cancer patients.
    4. the potential of Kp-10 to influence microvascular effects
      Title: The vasoactive potential of kisspeptin-10 in the peripheral vasculature.
    5. Data suggest that KiSS-1 expression in placenta is up-regulated in patients with preeclampsia as compared to control subjects. In this study, concordant expression of KiSS-1 and renin genes was not observed.
      Title: Comparative expression profiles for KiSS-1 and REN genes in preeclamptic and healthy placental tissues.
    6. KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion.
      Title: KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion.
    7. We describe an inactivating mutation in KISS1 in a large consanguineous family that results in failure of pubertal progression, indicating that functional kisspeptin is important for puberty and reproduction in humans.
      Title: Inactivating KISS1 mutation and hypogonadotropic hypogonadism.
    8. expression of the KiSS1 gene is regulated by transactivators and repressors involved in the system-wide control of mammalian puberty.
      Title: Transcriptional regulation of the human KiSS1 gene.
    9. Kisspeptin level was increased in prepubertal obese girls compared to healthy prepubertal girls.
      Title: Circulating kisspeptin levels exhibit sexual dimorphism in adults, are increased in obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty.
    10. coordinated expression patterns of the WASF3 metastasis promoter gene and the KISS1 metastasis suppressor gene appear to exert their influence through inhibition of NF-kappaB signaling, which in turn regulates MMP-9 production facilitating invasion.
      Title: Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells.
    Submit: New GeneRIF Correction See all (86)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Hypogonadotropic hypogonadism

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q15726 Q969F8 KISS1R    HPRD  PubMed  
    Q15726 P50281 MMP14    HPRD  PubMed  
    Q15726 P51512 MMP16    HPRD  PubMed  
    Q15726 P08253 MMP2    HPRD  PubMed  
    Q15726 Q9Y5R2 MMP24    HPRD  PubMed  
    Q15726 P14780 MMP9    HPRD  PubMed  
    BioGRID:110014 BioGRID:124162 KISS1R    BioGRID  PubMed Protein-peptide 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    metastasis-suppressor KiSS-1
    Names
    metastasis-suppressor KiSS-1
    metastin
    kisspeptin-1
    malignant melanoma metastasis-suppressor
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032151.1 RefSeqGene

      Range
      5001..11151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002256.3 → NP_002247.3  metastasis-suppressor KiSS-1 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AL592114, BC022819
      Consensus CDS
      CCDS41454.1
      UniProtKB/Swiss-Prot
      Q15726
      Related
      ENSP00000356162, OTTHUMP00000034312, ENST00000367194, OTTHUMT00000087892

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      204159469..204165619, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      175324487..175330608, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL592114.13 CAH71226.1
    genomic CH471067.1 EAW91506.1
      EAW91507.1
    genomic HC007062.1 CBH19336.1
    mRNA AF218017.1 AAG17259.1
    mRNA AK291695.1 BAF84384.1
    mRNA AY117143.1 AAM78592.1
    mRNA BC022819.1 AAH22819.1
    mRNA U43527.1 AAC79512.1
    other-genetic DQ892799.2 ABM83725.1
    other-genetic DQ896046.2 ABM87045.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15726.4 GenPept UniProtKB/Swiss-Prot:Q15726
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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