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Sf3b3 Splicing factor 3b subunit 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38093, updated on 4-Apr-2024

Summary

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Official Symbol
Sf3b3provided by FlyBase
Official Full Name
Splicing factor 3b subunit 3provided by FlyBase
Primary source
FLYBASE:FBgn0035162
Locus tag
Dmel_CG13900
See related
AllianceGenome:FB:FBgn0035162
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13900; Dmel\CG13900; SF3B3
Summary
Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of SAGA complex and U2 snRNP. Is expressed in several structures, including anterior endoderm; embryonic/larval muscle system; extended germ band embryo; gut section; and visceral muscle primordium. Orthologous to human SF3B3 (splicing factor 3b subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
61D2-61D2; 3-0.5 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (826720..833385, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (826720..833385, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44537 Neighboring gene long non-coding RNA:CR43883 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR45184 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analyses of essential genes in cytological region 61D1-2 to 61F1-2 of Drosophila melanogaster. Saito M, et al. Mol Genet Genomics, 2002 Dec. PMID 12471442
  2. Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster. Oliveira MS, et al. Mol Cell Biol, 2019 Aug 1. PMID 31085682, Free PMC Article
  3. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
  4. What do the structures of GCN5-containing complexes teach us about their function? Helmlinger D, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32739556
  5. Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module. Cornelio-Parra DV, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32911111

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables U2 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2 snRNP ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of catalytic step 2 spliceosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of precatalytic spliceosome HDA PubMed 
part_of small nuclear ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
splicing factor 3b subunit 3
Names
CG13900-PA
CG13900-PC
Sf3b3-PA
Sf3b3-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    826720..833385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167842.3 → NP_728546.1  splicing factor 3b subunit 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728546.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PDJ8, Q5BI86, Q9W0M7
    Related
    FBpp0072494
    Conserved Domains (2) summary
    pfam03178
    Location:872 → 1194
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:76 → 592
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term

  2. NM_001274294.2 → NP_001261223.1  splicing factor 3b subunit 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261223.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDJ8
    Conserved Domains (1) summary
    pfam10433
    Location:76 → 467
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T9L6 Q8T9L6
Q9W0M7.2 Q9W0M7

Gene LinkOut

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