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    p130CAS [ Drosophila melanogaster ]

    Gene ID: 38021, updated on 11-May-2012
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    Summary

    Official Symbol
    p130CASprovided by Flybase
    Primary source
    FLYBASE:FBgn0035101
    Locus tag
    Dmel_CG1212
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1212; CT1293; Dcas; DCas; Dmel\CG1212
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    Genomic context

    Location :
    61B1-61B2
    Sequence :
    Chromosome: 3L; NT_037436.3 (152884..174517)
    See p130CAS in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene CG6845 gene product from transcript CG6845-RE Neighboring gene CG7051 gene product from transcript CG7051-RA Neighboring gene CG43151 gene product from transcript CG43151-RA Neighboring gene CG7049 gene product from transcript CG7049-RA Neighboring gene Vitamin D[[3]] up-regulated protein 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Dcas supports cell polarization and cell-cell adhesion complexes in development. Tikhmyanova N, et al. PLoS One, 2010 Aug 24. PMID 20808771.
    3. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    4. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.
    5. Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development. Huang Z, et al. Development, 2007 Jun. PMID 17537798.

    See all (14) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. p130CAS signaling protein functions with integrins to specify axon guidance during development.
      Title: Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:63585 BioGRID:64163 Acp65Aa    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:63585 BioGRID:65655 CG11247    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:66688 CG11656    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:57891 CG2982    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:66870 CG3731    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:60718 CG5525    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:60005 CG9098    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:68262 CG9986    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:67832 Golgin84    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:61124 Grip71    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:61195 Pax    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:60352 borr    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:71022 mit(1)15    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:62328 opa1-like    BioGRID  PubMed Two-hybrid 
    BioGRID:63585 BioGRID:68196 wdb    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    Pathways from BioSystems

    mobile_element

    • Loc: 164030-164149 mobile_element_type = transposon:INE-1{}3913

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    axonal defasciculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		  
    cytoskeletal anchoring at plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG1212 gene product from transcript CG1212-RD
    Names
    CG1212-PB
    CG1212-PD
    CG1212-PE
    CG1212-PF
    CG1212-PG
    p130CAS
    p130CAS-PB
    p130CAS-PD
    p130CAS-PE
    p130CAS-PF
    p130CAS-PG
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      152884..174517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103986.3 → NP_001097456.2  p130CAS, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4IJ58
      Related
      FBpp0289142
      Conserved Domains (3) summary
      cd00174
      Location:81 – 136
      Blast Score: 147
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd11549
      Location:434 – 596
      Blast Score: 475
      Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
      cd11564
      Location:693 – 818
      Blast Score: 489
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    2. NM_001169831.2 → NP_001163302.1  p130CAS, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVE5
      Related
      FBpp0291103
      Conserved Domains (3) summary
      cd00174
      Location:43 – 98
      Blast Score: 145
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd11549
      Location:396 – 558
      Blast Score: 474
      Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
      cd11564
      Location:655 – 780
      Blast Score: 494
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    3. NM_167797.3 → NP_728478.1  p130CAS, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0H1
      UniProtKB/TrEMBL
      Q95U71
      Related
      FBpp0072377
      Conserved Domains (2) summary
      cd11549
      Location:171 – 333
      Blast Score: 467
      Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
      cd11564
      Location:430 – 555
      Blast Score: 486
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    4. NM_001144389.2 → NP_001137861.1  p130CAS, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0H1
      UniProtKB/TrEMBL
      Q95U71
      Related
      FBpp0289144
      Conserved Domains (2) summary
      cd11549
      Location:171 – 333
      Blast Score: 467
      Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
      cd11564
      Location:430 – 555
      Blast Score: 486
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    5. NM_001144388.2 → NP_001137860.1  p130CAS, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0H1
      Related
      FBpp0289143
      Conserved Domains (2) summary
      cd11549
      Location:170 – 332
      Blast Score: 467
      Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
      cd11564
      Location:429 – 554
      Blast Score: 486
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA BT030416.1 ABO52836.1
    genomic AE014296.4 ABW08421.2
    mRNA EF599121.1 ABQ96885.1
    genomic AE014296.4 ACZ94574.1
    mRNA AY058273.1 AAL13502.1
    genomic AE014296.4 ACL83217.1
    genomic AE014296.4 AAF47336.1
    genomic AE014296.4 ACL83216.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAF47335.2 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content