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KIR2DL1 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 [ Homo sapiens (human) ]

Gene ID: 3802, updated on 26-May-2016
Official Symbol
KIR2DL1provided by HGNC
Official Full Name
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1provided by HGNC
Primary source
HGNC:HGNC:6329
See related
Ensembl:ENSG00000125498 HPRD:12000; MIM:604936; Vega:OTTHUMG00000065885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKAT; NKAT1; p58.1; CD158A; KIR221; NKAT-1; KIR-K64
Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Location:
19q13.4
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (54769805..54784326)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55281265..55295778)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains pseudogene 1 Neighboring gene uncharacterized LOC101928804 Neighboring gene uncharacterized LOC102724300 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
immune response TAS
Traceable Author Statement
more info
PubMed 
natural killer cell inhibitory signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
killer cell immunoglobulin-like receptor 2DL1
Names
CD158 antigen-like family member A
MHC class I NK cell receptor
killer Ig receptor
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
killer inhibitory receptor 2-2-1
natural killer-associated transcript 1
p58 NK cell inhibitory receptor NKR-K6
p58 NK receptor CL-42/47.11
p58 killer cell inhibitory receptor KIR-K64
p58 natural killer cell receptor clones CL-42/47.11
p58.1 MHC class-I-specific NK receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005994.1 

    Range
    90267..104787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014218.2NP_055033.2  killer cell immunoglobulin-like receptor 2DL1 precursor

    See identical proteins and their annotated locations for NP_055033.2

    Status: REVIEWED

    Source sequence(s)
    AC011501, AY366237, AY366240
    Consensus CDS
    CCDS12904.1
    UniProtKB/Swiss-Prot
    P43626
    UniProtKB/TrEMBL
    Q6H2H2, Q6H2H3
    Related
    ENSP00000336769, OTTHUMP00000068618, ENST00000336077, OTTHUMT00000141148
    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    54769805..54784326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526939.1XP_011525241.1  

    See identical proteins and their annotated locations for XP_011525241.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    675474..689985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p2 ALT_REF_LOCI_2

    Range
    369241..402184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p2 ALT_REF_LOCI_7

    Range
    674139..688660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011548561.1XP_011546863.1  

    See identical proteins and their annotated locations for XP_011546863.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p2 ALT_REF_LOCI_9

    Range
    752371..766892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011548706.1XP_011547008.1  

    See identical proteins and their annotated locations for XP_011547008.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_10

Genomic

  1. NT_187636.1 Reference GRCh38.p2 ALT_REF_LOCI_10

    Range
    118418..132946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547137.1XP_011545439.1  

    See identical proteins and their annotated locations for XP_011545439.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_11

Genomic

  1. NT_187637.1 Reference GRCh38.p2 ALT_REF_LOCI_11

    Range
    84513..99034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547143.1XP_011545445.1  

    See identical proteins and their annotated locations for XP_011545445.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_13

Genomic

  1. NT_187639.1 Reference GRCh38.p2 ALT_REF_LOCI_13

    Range
    85082..99603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547146.1XP_011545448.1  

    See identical proteins and their annotated locations for XP_011545448.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_14

Genomic

  1. NT_187640.1 Reference GRCh38.p2 ALT_REF_LOCI_14

    Range
    73878..88399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_15

Genomic

  1. NT_187641.1 Reference GRCh38.p2 ALT_REF_LOCI_15

    Range
    124099..138620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547148.1XP_011545450.1  

    See identical proteins and their annotated locations for XP_011545450.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_17

Genomic

  1. NT_187643.1 Reference GRCh38.p2 ALT_REF_LOCI_17

    Range
    84773..99294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547155.1XP_011545457.1  

    See identical proteins and their annotated locations for XP_011545457.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_19

Genomic

  1. NT_187645.1 Reference GRCh38.p2 ALT_REF_LOCI_19

    Range
    84789..99310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547163.1XP_011545465.1  

    See identical proteins and their annotated locations for XP_011545465.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_20

Genomic

  1. NT_187668.1 Reference GRCh38.p2 ALT_REF_LOCI_20

    Range
    74675..89192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547543.1XP_011545845.1  

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_21

Genomic

  1. NT_187669.1 Reference GRCh38.p2 ALT_REF_LOCI_21

    Range
    84773..99294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547545.1XP_011545847.1  

    See identical proteins and their annotated locations for XP_011545847.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_23

Genomic

  1. NT_187671.1 Reference GRCh38.p2 ALT_REF_LOCI_23

    Range
    48718..63238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547556.1XP_011545858.1  

    See identical proteins and their annotated locations for XP_011545858.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_24

Genomic

  1. NT_187672.1 Reference GRCh38.p2 ALT_REF_LOCI_24

    Range
    71391..85904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_25

Genomic

  1. NT_187673.1 Reference GRCh38.p2 ALT_REF_LOCI_25

    Range
    84752..99273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547559.1XP_011545861.1  

    See identical proteins and their annotated locations for XP_011545861.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_26

Genomic

  1. NT_187674.1 Reference GRCh38.p2 ALT_REF_LOCI_26

    Range
    56653..71164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_27

Genomic

  1. NT_187675.1 Reference GRCh38.p2 ALT_REF_LOCI_27

    Range
    112804..127332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547568.1XP_011545870.1  

    See identical proteins and their annotated locations for XP_011545870.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_28

Genomic

  1. NT_187676.1 Reference GRCh38.p2 ALT_REF_LOCI_28

    Range
    45719..60240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547575.1XP_011545877.1  

    See identical proteins and their annotated locations for XP_011545877.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_30

Genomic

  1. NT_187683.1 Reference GRCh38.p2 ALT_REF_LOCI_30

    Range
    43990..58502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_31

Genomic

  1. NT_187684.1 Reference GRCh38.p2 ALT_REF_LOCI_31

    Range
    86260..100786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547806.1XP_011546108.1  

    See identical proteins and their annotated locations for XP_011546108.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_32

Genomic

  1. NT_187685.1 Reference GRCh38.p2 ALT_REF_LOCI_32

    Range
    84265..98786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547809.1XP_011546111.1  

    See identical proteins and their annotated locations for XP_011546111.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_33

Genomic

  1. NT_187686.1 Reference GRCh38.p2 ALT_REF_LOCI_33

    Range
    85114..99642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547810.1XP_011546112.1  

    See identical proteins and their annotated locations for XP_011546112.1

    Conserved Domains (2) summary
    cd05711
    Location:28122
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:128216
    Ig; Immunoglobulin domain

Reference GRCh38.p2 ALT_REF_LOCI_34

Genomic

  1. NT_187687.1 Reference GRCh38.p2 ALT_REF_LOCI_34

    Range
    84577..99087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    55274832..55289346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)