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    KIF5C kinesin family member 5C [ Homo sapiens ]

    Gene ID: 3800, updated on 11-May-2012
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    Summary

    Official Symbol
    KIF5Cprovided by HGNC
    Official Full Name
    kinesin family member 5Cprovided by HGNC
    Primary source
    HGNC:6325
    See related
    Ensembl:ENSG00000168280; MIM:604593; Vega:OTTHUMG00000153779
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KINN; NKHC; NKHC2; NKHC-2; FLJ44735; KIAA0531; MGC111478
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
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    Genomic context

    Location :
    2q23.1
    Sequence :
    Chromosome: 2; NC_000002.11 (149632819..149686923)
    Chromosome: 2; NC_000002.11 (149793796..149883273)
    See KIF5C in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 8 pseudogene Neighboring gene ribosomal protein S20 pseudogene 13 Neighboring gene LY6/PLAUR domain containing 6B Neighboring gene thioredoxin pseudogene Neighboring gene family with sequence similarity 8, member A1 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    4. The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility. Wang X, et al. Cell, 2009 Jan 9. PMID 19135897.
    5. KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit. Schäfer B, et al. Cell Mol Life Sci, 2009 Jan. PMID 19011756.

    See all (18) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Results identified the motor neuron protein KIF5C as a new binding partner for the protein kinase CK2alpha'.
      Title: KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit.
    3. KIF5C, a member of the kinesin 1 heavy chain family, is a substrate for protein kinase CK2.
      Title: The kinesin I family member KIF5C is a novel substrate for protein kinase CK2.
    4. binding of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function
      Title: Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.
    5. analysis of the GRIF-1 binding domain of the kinesin, KIF5C, which substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes
      Title: Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O60282 Q9UPV9 TRAK1    BIND  PubMed OIP106 interacts with KIF5C. 
    BioGRID:110001 BioGRID:107841 CSNK2A1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110001 BioGRID:110000 KIF5B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110001 BioGRID:110029 KLC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110001 BioGRID:122313 KLC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110001 BioGRID:117101 SNAPIN    BioGRID  PubMed Two-hybrid 
    BioGRID:110001 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110001 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110001 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    apolipoprotein receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    motor axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    organelle organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    ciliary rootlet IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinesin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    kinesin heavy chain isoform 5C
    Names
    kinesin heavy chain isoform 5C
    kinesin heavy chain neuron-specific 2
    kinesin, heavy chain, neuron-specific
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004522.2 → NP_004513.1  kinesin heavy chain isoform 5C

      Status: PROVISIONAL

      Source sequence(s)
      AB011103, AB209191, AW162840, DA085551
      UniProtKB/Swiss-Prot
      O60282
      UniProtKB/TrEMBL
      Q59GB8
      Related
      ENSP00000393379, OTTHUMP00000204430, ENST00000435030, OTTHUMT00000332562
      Conserved Domains (2) summary
      cd01369
      Location:6 – 327
      Blast Score: 1491
      KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup. Members of this group have been associated with organelle transport. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are ...
      COG1196
      Location:412 – 713
      Blast Score: 107
      Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      149632819..149686923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571033.1 Reference GRCh37.p5 PATCHES

      Range
      3214..96132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      141630838..141685093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC073271.4 (115296..117929) None
    genomic AC105402.5 AAY24013.1
    genomic AC108512.4 AAX82030.1
    genomic AC144443.2 AAX82036.1
    genomic AC144611.2 AAX82035.1
    genomic AC153810.1 (3659..8223) None
    genomic CH471058.2 EAX11544.1
    mRNA AB011103.1 BAA25457.2
    mRNA AB073396.1 BAE45725.1
    mRNA AB209191.1 BAD92428.1
    mRNA AF010146.1 AAD01436.1
    mRNA AK126689.1 None
    mRNA AL050070.1 None
    mRNA AL117393.1 CAB55895.2
    mRNA AW162840.1 None
    mRNA BC002721.2 AAH02721.1
    mRNA BC017298.2 AAH17298.1
    mRNA BC025961.1 AAH25961.1
    mRNA BC110287.1 AAI10288.1
    mRNA BC127772.1 AAI27773.1
    mRNA DA085551.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60282.1 GenPept UniProtKB/Swiss-Prot:O60282
    Q3LIE3 GenPept UniProtKB/TrEMBL:Q3LIE3
    Q53QT4 GenPept UniProtKB/TrEMBL:Q53QT4
    Q57YV5 GenPept UniProtKB/TrEMBL:Q57YV5
    Q57YV6 GenPept UniProtKB/TrEMBL:Q57YV6
    Q57Z91 GenPept UniProtKB/TrEMBL:Q57Z91
    Q59GB8 GenPept UniProtKB/TrEMBL:Q59GB8
    Q6PJC4 GenPept UniProtKB/TrEMBL:Q6PJC4
    Q6PKD1 GenPept UniProtKB/TrEMBL:Q6PKD1
    Q9UFW7 GenPept UniProtKB/TrEMBL:Q9UFW7
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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