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    KIF5B kinesin family member 5B [ Homo sapiens ]

    Gene ID: 3799, updated on 19-May-2012
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    Summary

    Official Symbol
    KIF5Bprovided by HGNC
    Official Full Name
    kinesin family member 5Bprovided by HGNC
    Primary source
    HGNC:6324
    See related
    Ensembl:ENSG00000170759; HPRD:07214; MIM:602809; Vega:OTTHUMG00000017913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KNS; KINH; KNS1; UKHC
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    Genomic context

    Location :
    10p11.22
    Sequence :
    Chromosome: 10; NC_000010.10 (32297938..32345371, complement)
    See KIF5B in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 12 Neighboring gene uncharacterized LOC100652968 Neighboring gene high mobility group box 1 pseudogene 7 Neighboring gene ribosomal protein L34 pseudogene 19 Neighboring gene ribosomal protein S4X pseudogene 11 Neighboring gene RNA, U7 small nuclear 22 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A metal switch for controlling the activity of molecular motor proteins. Cochran JC, et al. Nat Struct Mol Biol, 2011 Dec 25. PMID 22198464.
    2. Arl8 and SKIP act together to link lysosomes to kinesin-1. Rosa-Ferreira C, et al. Dev Cell, 2011 Dec 13. PMID 22172677.
    3. Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection. Strunze S, et al. Cell Host Microbe, 2011 Sep 15. PMID 21925109.
    4. A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome. Dodding MP, et al. EMBO J, 2011 Nov 16. PMID 21915095.
    5. Probing the structural and energetic basis of kinesin-microtubule binding using computational alanine-scanning mutagenesis. Li M, et al. Biochemistry, 2011 Oct 11. PMID 21910419.

    See all (59) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data indicate that mutant KIF5B kinesin-1 binds ATP similarly in the presence of either metal ion, but its ATP hydrolysis activity is greatly diminished in the presence of Mg(2+).
      Title: A metal switch for controlling the activity of molecular motor proteins.
    2. Arl8 and SKIP are required for lysosomes to distribute away from the microtubule-organizing center. We identify two kinesin light chain binding motifs in SKIP that are required for lysosomes to accumulate kinesin-1 and redistribute to the cell periphery.
      Title: Arl8 and SKIP act together to link lysosomes to kinesin-1.
    3. Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection.
      Title: Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection.
    4. findings show a bipartite tryptophan-based motif in vaccinia virus A36 is required for kinesin-1-dependent transport of the virus; bioinformatic analysis reveals that related bipartite tryptophan-based motifs are present in over 450 human proteins
      Title: A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome.
    5. The conventional kinesin-microtubule binding free energy is dominated by van der Waals interactions and electrostatic interactions.
      Title: Probing the structural and energetic basis of kinesin-microtubule binding using computational alanine-scanning mutagenesis.
    6. The discovery of the novel KIF5B-ALK variant further consolidated the role of aberrant anaplastic lymphoma kinase signaling in lung carcinogenesis.
      Title: A novel KIF5B-ALK variant in nonsmall cell lung cancer.
    7. the interaction between the kinesin-1 head and its regulatory tail domain
      Title: The Kinesin-1 tail conformationally restricts the nucleotide pocket.
    8. a kinesin-1 tail fragment associates with microtubules with submicromolar affinity and binding is largely electrostatic
      Title: Microtubule-associated protein-like binding of the kinesin-1 tail to microtubules.
    9. This indicates that kinesin-1 facilitates the transport of SNAP-25 containing vesicles as a prerequisite to SNAP-25 driven membrane fusion events.
      Title: Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane.
    10. Na,K-ATPase traffic toward the plasma membrane in alveolar epithelial cells is driven by kinesin-1, where KLC2 is the isoform regulating this process.
      Title: Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells.
    Submit: New GeneRIF Correction See all (26)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004512.1 BAA74865.1 PLEKHM2    BIND  PubMed SKIP interacts with kinesin HC. 
    NP_004512.1 Q9UPV9 TRAK1    BIND  PubMed OIP106 interacts with KIF5B. 
    P33176 Q12840 KIF5A    HPRD  PubMed  
    P33176 Q6P597 KLC3    HPRD  PubMed  
    P33176 Q86UP2 KTN1    HPRD  PubMed  
    P33176 Q15596 NCOA2    HPRD  PubMed  
    P33176 Q92597 NDRG1    HPRD  PubMed  
    P33176 Q9P2E9 RRBP1    HPRD  PubMed  
    P33176 O00161 SNAP23    HPRD  PubMed  
    P33176 P60880 SNAP25    HPRD  PubMed  
    P33176 Q9NX95 SYBU    HPRD  PubMed  
    P33176 P31946 YWHAB    HPRD  PubMed  
    P33176 P61981 YWHAG    HPRD  PubMed  
    P33176 P27348 YWHAQ    HPRD  PubMed  
    P33176 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:110000 BioGRID:106821 APC    BioGRID  PubMed Two-hybrid 
    BioGRID:110000 BioGRID:107424 CDC5L    BioGRID  PubMed Two-hybrid 
    BioGRID:110000 BioGRID:108171 DTNB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110000 BioGRID:122669 FYCO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:109187 GSK3B    BioGRID  PubMed Two-hybrid 
    BioGRID:110000 BioGRID:110001 KIF5C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110000 BioGRID:110029 KLC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110000 BioGRID:122313 KLC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110000 BioGRID:108326 MARK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:115669 NDRG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:110895 NME2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:115045 RAPGEF2    BioGRID  PubMed Two-hybrid 
    BioGRID:110000 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:114303 SNAP23    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110000 BioGRID:112500 SNAP25    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110000 BioGRID:116734 SPG20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:115503 USPL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:113259 VDAC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:113365 YWHAH    BioGRID  PubMed Affinity Capture-MS; Far Western 
    BioGRID:110000 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110000 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Diabetes pathways, organism-specific biosystem (from REACTOME)
      Diabetes pathways, organism-specific biosystemThis module groups several normal processes that have key roles in the synthesis and function of insulin, insulin-like growth factors and ghrelin, and whose derangement is thus central to the pathoge...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • Insulin Synthesis and Processing, organism-specific biosystem (from REACTOME)
      Insulin Synthesis and Processing, organism-specific biosystemThe generation of insulin-containing secretory granules from proinsulin in the lumen of the endoplasmic reticulum (ER) can be described in 4 steps: formation of intramolecular disulfide bonds, format...
    • Kinesins, organism-specific biosystem (from REACTOME)
      Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
    • N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
      N-cadherin signaling events, organism-specific biosystem
      N-cadherin signaling events

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cytoplasm organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    stress granule disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    vesicle transport along microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    ciliary rootlet IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinesin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    vesicle IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    kinesin-1 heavy chain
    Names
    kinesin-1 heavy chain
    kinesin heavy chain
    kinesin 1 (110-120kD)
    ubiquitous kinesin heavy chain
    conventional kinesin heavy chain
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004521.2 → NP_004512.1  kinesin-1 heavy chain

      Status: VALIDATED

      Source sequence(s)
      AL161932, BC065267, BP361225, BU633712, DC399931, X65873
      Consensus CDS
      CCDS7171.1
      UniProtKB/Swiss-Prot
      P33176
      UniProtKB/TrEMBL
      Q6P164
      Related
      ENSP00000307078, OTTHUMP00000019411, ENST00000302418, OTTHUMT00000047467
      Conserved Domains (2) summary
      cd01369
      Location:6 – 325
      Blast Score: 1454
      KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup. Members of this group have been associated with organelle transport. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are ...
      TIGR02168
      Location:414 – 803
      Blast Score: 170
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      32297938..32345371, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      32018111..32065919, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL161932.15 CAH71618.1
    genomic CH471072.2 EAW85976.1
      EAW85977.1
    mRNA AK289413.1 BAF82102.1
    mRNA AK299542.1 BAG61489.1
    mRNA AK307502.1 None
    mRNA BC010885.1 None
    mRNA BC065267.1 AAH65267.1
    mRNA BC080604.1 AAH80604.1
    mRNA BC111042.1 AAI11043.1
    mRNA BC126279.1 AAI26280.1
    mRNA BC126281.1 AAI26282.1
    mRNA BP361225.1 None
    mRNA BU633712.1 None
    mRNA DC399931.1 None
    mRNA X65873.1 CAA46703.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33176.1 GenPept UniProtKB/Swiss-Prot:P33176
    Q2TA90 GenPept UniProtKB/TrEMBL:Q2TA90
    Q66K46 GenPept UniProtKB/TrEMBL:Q66K46
    Q6P164 GenPept UniProtKB/TrEMBL:Q6P164
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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