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Tina-1 Troponin C-akin-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37989, updated on 4-Apr-2024

Summary

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Official Symbol
Tina-1provided by FlyBase
Official Full Name
Troponin C-akin-1provided by FlyBase
Primary source
FLYBASE:FBgn0035083
Locus tag
Dmel_CG2803
See related
AllianceGenome:FB:FBgn0035083
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GM14784; CG2803; Dmel\CG2803
Summary
Predicted to enable gamma-glutamylaminecyclotransferase activity. Predicted to be involved in heart development. Predicted to be active in cytosol. Is expressed in adult head; adult heart; and embryonic/larval heart. Orthologous to human GGACT (gamma-glutamylamine cyclotransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Tina-1 in Genome Data Viewer
Location:
60E5-60E8; 2-107 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24940625..24942413, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20828148..20829936, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel. Lovato TL, et al. Development, 2002 Nov. PMID 12397110
  2. Second chromosome genes required for heart development in Drosophila melanogaster. Tao Y, et al. Genesis, 2007 Oct. PMID 17941041
  3. Establishing A-P polarity in the embryonic heart tube: a conserved function of Hox genes in Drosophila and vertebrates? Lo PC, et al. Trends Cardiovasc Med, 2003 Jul. PMID 12837580
  4. Microarray analysis of the gene expression profiles of SL2 cells stimulated by LPS/PGN and curdlan. Jin LH, et al. Mol Cells, 2008 Jun 30. PMID 18460901
  5. Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase. Chen CL, et al. Proc Natl Acad Sci U S A, 2015 Sep 29. PMID 26362788, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gamma-glutamylaminecyclotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables gamma-glutamylaminecyclotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of muscle NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in heart development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
troponin C-akin-1
Names
CG2803-PA
CG2803-PB
Tina-1-PA
Tina-1-PB
NP_001033974.1
NP_611983.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24940625..24942413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138139.4 → NP_611983.2  troponin C-akin-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611983.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95T30, Q9W0Y1
    Related
    FBpp0072317
    Conserved Domains (1) summary
    pfam06094
    Location:14 → 130
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

  2. NM_001038885.2 → NP_001033974.1  troponin C-akin-1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033974.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PE12
    Conserved Domains (1) summary
    cl22886
    Location:1 → 38
    GGCT_like; GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2PE12 Q2PE12
Q9W0Y1.1 Q9W0Y1

Gene LinkOut

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