U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NaCP60E Na channel protein 60E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37981, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
NaCP60Eprovided by FlyBase
Official Full Name
Na channel protein 60Eprovided by FlyBase
Primary source
FLYBASE:FBgn0085434
Locus tag
Dmel_CG34405
See related
AllianceGenome:FB:FBgn0085434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18506; CG34405; CG9071; CT24831; DIC60; Dmel\CG34405; dsc; DSC; dsc1; DSC1; DSCI; Na-CP; smi60E
Old locus tag
CG18506; CG9071; Dmel_CG18506; Dmel_CG9071
Summary
Enables voltage-gated cation channel activity. Involved in olfactory behavior. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Is expressed in several structures, including adult central nervous system; anterior-posterior subdivision of organism; neuron projection bundle; region of integument; and spermatozoon. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and developmental and epileptic encephalopathy 13. Orthologous to human SCN8A (sodium voltage-gated channel alpha subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
60E5-60E5; 2-107 cM
Exon count:
31
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24891614..24921677)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20779137..20809200)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43466 Neighboring gene Na,K-ATPase Interacting Neighboring gene Ance-5 Neighboring gene uncharacterized protein Neighboring gene Thiamine pyrophosphate carrier protein 2 Neighboring gene Ribosomal protein L41 Neighboring gene painless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. Dong K, et al. Pestic Biochem Physiol, 2015 May. PMID 25987218
  2. Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids. Rinkevich FD, et al. Neurotoxicology, 2015 Mar. PMID 25687544, Free PMC Article
  3. Nucleotide sequence of the putative sodium channel gene from Drosophila: the four homologous domains. Salkoff L, et al. Nucleic Acids Res, 1987 Oct 26. PMID 2444928, Free PMC Article
  4. DSC1 channel-dependent developmental regulation of pyrethroid susceptibility in Drosophila melanogaster. Chen X, et al. Pestic Biochem Physiol, 2018 Jun. PMID 29891372
  5. Molecular characterization and functional expression of the DSC1 channel. Zhang T, et al. Insect Biochem Mol Biol, 2011 Jul. PMID 21571069, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We summarize major findings from recent studies and highlight a unique role of the DSC1 channel, distinct from that of the sodium channel, in regulating membrane excitability and modulating toxicity of pyrethroid insecticides
    Title: The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels.
  2. These results reveal an important role of the DSC1 channel in modulating the stability of neural circuits, particularly under environmental stresses, likely by maintaining the sustainability of synaptic transmission.
    Title: Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress.
  3. This study showed that transcripts lacking all cytoplasmic alternatively spliced exons still produce functional channels'
    Title: Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, inactivation, and persistent current.
  4. DSC1 channels are expressed in both the central and the peripheral nervous system of adult Drosophila melanogaster.
    Title: DSC1 channels are expressed in both the central and the peripheral nervous system of adult Drosophila melanogaster.
  5. These results identify nebula/DSCR1 as a regulator of mitochondrial function and integrity and further suggest that an increased level of DSCR1 may contribute to the mitochondrial dysfunction seen in Down syndrome.
    Title: Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

mobile_element

  • Loc: 24919232-24919276 mobile_element_type = transposon:1360{}5042

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monoatomic cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated sodium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables voltage-gated sodium channel activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane depolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neuronal action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in olfactory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Na channel protein 60E
Names
CG34405-PG
CG34405-PH
CG34405-PI
CG34405-PJ
CG34405-PK
CG34405-PL
CG34405-PM
CG34405-PN
CG34405-PO
CG34405-PP
Na-channel-protein
NaCP60E-PG
NaCP60E-PH
NaCP60E-PI
NaCP60E-PJ
NaCP60E-PK
NaCP60E-PL
NaCP60E-PM
NaCP60E-PN
NaCP60E-PO
NaCP60E-PP
put. sodium channel gene
smell impaired 60E
sodium channel 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24891614..24921677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259579.3 → NP_001246508.1  Na channel protein 60E, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246508.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K814
    Conserved Domains (3) summary
    cd13433
    Location:2009 → 2063
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1768 → 2019
    Ion_trans; Ion transport protein
    pfam16905
    Location:2331 → 2386
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. NM_166696.5 → NP_726495.3  Na channel protein 60E, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726495.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4KF50, A9NIV8, Q27930, Q7JN09, Q7JN86, Q7JN87, Q7JN88, Q7JN89, Q7K324, Q8MMC7, Q9W0Y8
    Conserved Domains (4) summary
    cd13433
    Location:2009 → 2063
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1751 → 2019
    Ion_trans; Ion transport protein
    pfam16905
    Location:2325 → 2386
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl25732
    Location:1152 → 1421
    SMC_N; RecF/RecN/SMC N terminal domain

  3. NM_001259581.2 → NP_001246510.1  Na channel protein 60E, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246510.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7I8
    Conserved Domains (3) summary
    cd13433
    Location:2009 → 2063
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1768 → 2019
    Ion_trans; Ion transport protein
    pfam16905
    Location:2331 → 2386
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. NM_001274245.2 → NP_001261174.1  Na channel protein 60E, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261174.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG05, D6W4K7
    Conserved Domains (1) summary
    pfam00520
    Location:152 → 361
    Ion_trans; Ion transport protein

  5. NM_001274244.2 → NP_001261173.1  Na channel protein 60E, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261173.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGE9
    Conserved Domains (1) summary
    pfam00520
    Location:705 → 902
    Ion_trans; Ion transport protein

  6. NM_001259580.2 → NP_001246509.1  Na channel protein 60E, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246509.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K887
    Conserved Domains (3) summary
    cd13433
    Location:2014 → 2068
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1773 → 2024
    Ion_trans; Ion transport protein
    pfam16905
    Location:2336 → 2391
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  7. NM_001274246.2 → NP_001261175.1  Na channel protein 60E, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261175.1

    Status: REVIEWED

    Conserved Domains (2) summary
    cd13433
    Location:2009 → 2063
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1768 → 2019
    Ion_trans; Ion transport protein

  8. NM_001274243.2 → NP_001261172.1  Na channel protein 60E, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261172.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFH8
    Conserved Domains (3) summary
    cd13433
    Location:2009 → 2063
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1768 → 2019
    Ion_trans; Ion transport protein
    pfam16905
    Location:2331 → 2386
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  9. NM_001202078.3 → NP_001189007.2  Na channel protein 60E, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189007.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4KF50, A9NIV8, Q27930, Q7JN09, Q7JN86, Q7JN87, Q7JN88, Q7JN89, Q7K324, Q8MMC7, Q9W0Y8
    Conserved Domains (4) summary
    cd13433
    Location:2009 → 2063
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1751 → 2019
    Ion_trans; Ion transport protein
    pfam16905
    Location:2325 → 2386
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    cl25732
    Location:1152 → 1421
    SMC_N; RecF/RecN/SMC N terminal domain

  10. NM_001259578.1 → NP_001246507.1  Na channel protein 60E, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246507.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K8B5
    Conserved Domains (3) summary
    cd13433
    Location:1877 → 1931
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1636 → 1887
    Ion_trans; Ion transport protein
    pfam16905
    Location:2199 → 2254
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7I8 A0A0B4K7I8
A0A0B4K814 A0A0B4K814
A0A0B4K887 A0A0B4K887
A0A0B4K8B5 A0A0B4K8B5
A0A0B4KFH8 A0A0B4KFH8
A0A0B4KG05 A0A0B4KG05
A0A0B4KGE9 A0A0B4KGE9
Q9W0Y8.6 Q9W0Y8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous