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    NaCP60E Na channel protein 60E [ Drosophila melanogaster ]

    Gene ID: 37981, updated on 10-May-2012
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    Summary

    Official Symbol
    NaCP60Eprovided by Flybase
    Official Full Name
    Na channel protein 60Eprovided by Flybase
    Primary source
    FLYBASE:FBgn0085434
    Locus tag
    Dmel_CG34405
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18506; CG34405; CG9071; CT24831; DIC60; Dmel\CG34405; DSC; dsc1; DSC1; DSCI; Na-CP; smi60E
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    Genomic context

    Location :
    60E5-60E5
    Sequence :
    Chromosome: 2R; NT_033778.3 (20779163..20807797)
    See NaCP60E in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Na,K-ATPase Interacting Neighboring gene CG10142 gene product from transcript CG10142-RA Neighboring gene CG9083 gene product from transcript CG9083-RB Neighboring gene Thiamine pyrophosphate carrier protein 2 Neighboring gene Ribosomal protein L41 Neighboring gene painless Neighboring gene CG30427 gene product from transcript CG30427-RC

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Two types of Ca2+ channel linked to two endocytic pathways coordinately maintain synaptic transmission at the Drosophila synapse. Kuromi H, et al. Eur J Neurosci, 2010 Aug. PMID 20704589.
    2. Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, inactivation, and persistent current. Lin WH, et al. J Neurophysiol, 2009 Sep. PMID 19625535.
    3. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    4. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.
    5. A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing. Molnar C, et al. Genetics, 2006 Nov. PMID 16980395.

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This study showed that transcripts lacking all cytoplasmic alternatively spliced exons still produce functional channels'
      Title: Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, inactivation, and persistent current.
    2. DSC1 channels are expressed in both the central and the peripheral nervous system of adult Drosophila melanogaster.
      Title: DSC1 channels are expressed in both the central and the peripheral nervous system of adult Drosophila melanogaster.
    3. These results identify nebula/DSCR1 as a regulator of mitochondrial function and integrity and further suggest that an increased level of DSCR1 may contribute to the mitochondrial dysfunction seen in Down syndrome.
      Title: Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:63549 BioGRID:59405 CG14614    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:58464 CG18292    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:64899 CG32138    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:60630 CG6509    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:62076 CG8888    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:68520 CanA1    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:64701 CycA    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:68443 Mlc2    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:58891 Myb    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:61640 Nup50    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:58962 Pp2B-14D    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:68008 RASSF8    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:78249 RpL5    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:60062 Sec61alpha    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:59691 Taf10b    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:69807 Tapdelta    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:67106 cher    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:69215 lolal    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:63699 msd5    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:58943 nonA    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:62753 pAbp    BioGRID  PubMed Two-hybrid 
    BioGRID:63549 BioGRID:60626 salm    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    mobile_element

    • Loc: 20806755-20806799 mobile_element_type = transposon:1360{}5042

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    voltage-gated sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    voltage-gated sodium channel activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    sodium ion transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    voltage-gated sodium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    CG34405 gene product from transcript CG34405-RH
    Names
    CG34405-PG
    CG34405-PH
    CG34405-PI
    CG34405-PJ
    CG34405-PK
    CG34405-PL
    Na channel protein 60E
    Na-channel-protein
    NaCP60E-PG
    NaCP60E-PH
    NaCP60E-PI
    NaCP60E-PJ
    NaCP60E-PK
    NaCP60E-PL
    put. sodium channel gene
    smell impaired 60E
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      20779163..20807797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202078.2 → NP_001189007.2  Na channel protein 60E, isoform H [Drosophila melanogaster]

      Status: REVIEWED

    2. NM_001259579.1 → NP_001246508.1  Na channel protein 60E, isoform J [Drosophila melanogaster]

      Status: REVIEWED

    3. NM_166696.4 → NP_726495.3  Na channel protein 60E, isoform G [Drosophila melanogaster]

      Status: REVIEWED

    4. NM_001259581.1 → NP_001246510.1  Na channel protein 60E, isoform L [Drosophila melanogaster]

      Status: REVIEWED

    5. NM_001259580.1 → NP_001246509.1  Na channel protein 60E, isoform K [Drosophila melanogaster]

      Status: REVIEWED

    6. NM_001259578.1 → NP_001246507.1  Na channel protein 60E, isoform I [Drosophila melanogaster]

      Status: REVIEWED

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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAM70798.3
    genomic AE013599.4 AFH08261.1
    genomic AE013599.4 AAF47291.6
    genomic AE013599.4 AFH08263.1
    genomic AE013599.4 AFH08262.1
    genomic AE013599.4 AFH08260.1
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    Additional Links

    Gene LinkOut

      Supplemental Content

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