Dll Distal-less [Drosophila melanogaster] - Gene

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Summary

Official Symbol: Dllprovided by Flybase
Official Full Name: Distal-lessprovided by Flybase
Primary source: FLYBASE:FBgn0000157
Locus tag: Dmel_CG3629
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2.7; Art; Ba; BcDNA:LP01770; CG3629; dl; dll; DLL; Dmel\CG3629; E(Arp); En(Arp); l(2)01092; l(2)387

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Genomic context

Location :: 60E2-60E2; 2-107.8 cM

Sequence :: Chromosome: 2R; NT_033778.3 (20702353..20722686)

See Dll in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

studied a 17kb genomic region in the Dll locus which lies downstream of the coding sequence and found control elements of primary functional importance for the expression of Dll in the leg and in other tissues
Title: Control of Distal-less expression in the Drosophila appendages by functional 3' enhancers.
The medial leg fates are established via a regulatory cascade in which Wg+Dpp activate Distalless and then Distalless directly activates dac, with Wg+Dpp as less critical, permissive inputs.
Title: Establishment of medial fates along the proximodistal axis of the Drosophila leg through direct activation of dachshund by Distalless.
disco plays a fundamental role in the Dll-dependent patterning of antenna and leg, perhaps as a regulator of Dll gene expression
Title: Mutual regulation of the Drosophila disconnected (disco) and Distal-less (Dll) genes contributes to proximal-distal patterning of antenna and leg.
These findings provide a complete and high-resolution fate map of the Drosophila appendage primordia, linking the primary domains to specific cis-regulatory elements in Dll.
Title: The origins of the Drosophila leg revealed by the cis-regulatory architecture of the Distalless gene.
The development of the Drosophila leg requires both Decapentaplegic (Dpp) and Wingless (Wg), two signals that establish the proximo-distal (PD) axis by activating target genes such as Distalless.
Title: Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development.
Hox protein Ultrabithorax (Ubx) suppresses limb formation in the abdomen by repressing the leg selector gene Distalless
Title: Specificity of Distalless repression and limb primordia development by abdominal Hox proteins.
Distal-less...specify antenna fates via regulation of multiple genes.
Title: Distal-less and homothorax regulate multiple targets to pattern the Drosophila antenna.
Dll functions in subdividing the thoracic limb primordium.
Title: Distal-less functions in subdividing the Drosophila thoracic limb primordium.
abdominal Hox proteins work directly with two segmentation proteins, Sloppy paired and Engrailed, to repress the Hox target gene Distalless in anterior and posterior compartments, respectively; segmentation proteins can function as Hox cofactors
Title: Direct integration of Hox and segmentation gene inputs during Drosophila development.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:63542	BioGRID:62391	BEAF-32	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63542	BioGRID:61233	CG10262	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:63867	CG11486	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:60579	CG14071	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:68662	CG32016	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:62199	CG3884	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:61068	CG5674	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:61084	CG5783	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:60245	CG8455	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:61339	CG9248	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:62461	Cdk5	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:60913	Cul-3	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:64171	D19A	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:61846	Orc6	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:65606	Pc	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63542	BioGRID:61322	RPA2	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:62202	Su(z)2	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63542	BioGRID:62880	Tab2	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:60206	cdc14	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:64116	mad2	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:58968	mbt	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:68673	nej	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:69325	plu	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:57644	png	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:61717	sec31	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:65303	star1	BioGRID	PubMed	Two-hybrid
BioGRID:63542	BioGRID:70682	term	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the Dll gene: The Dll gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, and mosquito.

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	NAS Non-traceable Author Statement more info
transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
analia development	TAS Traceable Author Statement more info	PubMed
antennal development	IMP Inferred from Mutant Phenotype more info	PubMed
antennal development	TAS Traceable Author Statement more info	PubMed
determination of ventral identity	IMP Inferred from Mutant Phenotype more info	PubMed
genital disc development	TAS Traceable Author Statement more info	PubMed
imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
imaginal disc-derived limb morphogenesis	NAS Non-traceable Author Statement more info
imaginal disc-derived male genitalia development	NAS Non-traceable Author Statement more info	PubMed
imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
leg disc proximal/distal pattern formation	TAS Traceable Author Statement more info	PubMed
negative regulation of gene expression	IEP Inferred from Expression Pattern more info	PubMed
proboscis development	IMP Inferred from Mutant Phenotype more info	PubMed
proximal/distal pattern formation, imaginal disc	NAS Non-traceable Author Statement more info
proximal/distal pattern formation, imaginal disc	TAS Traceable Author Statement more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
specification of organ identity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info
nucleus	NAS Non-traceable Author Statement more info

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General protein information

Preferred Names: CG3629 gene product from transcript CG3629-RA

Names: CG3629-PA; CG3629-PB; CG3629-PC; Distal-less; Distall-less; Dll-PA; Dll-PB; Dll-PC; brista; distal-less; distalless; enhancer of Arp

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

20702353..20722686

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079133.1 → NP_523857.1 Distal-less, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P20009

Related

FBpp0072286, FBtr0072379

Conserved Domains (1) summary

cd00086
Location:125 – 183
Blast Score: 157

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001144287.1 → NP_001137759.1 Distal-less, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A2VEF7

Related

FBpp0289353, FBtr0300076

Conserved Domains (1) summary

cd00086
Location:125 – 183
Blast Score: 158

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_166689.1 → NP_726486.1 Distal-less, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P20009

Related

FBpp0072285, FBtr0072378

Conserved Domains (1) summary

cd00086
Location:125 – 183
Blast Score: 157

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.