KIF2A kinesin heavy chain member 2A [Homo sapiens] - Gene

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Summary

Official Symbol: KIF2Aprovided by HGNC
Official Full Name: kinesin heavy chain member 2Aprovided by HGNC
Primary source: HGNC:6318
See related: Ensembl:ENSG00000068796; HPRD:03996; MIM:602591; Vega:OTTHUMG00000097755
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HK2; KIF2
Summary: The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

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Genomic context

Location :: 5q12-q13

Sequence :: Chromosome: 5; NC_000005.9 (61601989..61682210)

See KIF2A in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The kinesin-2 deficiency weakened intercellular adhesion, despite the maintenance of adherens junctions and other desmosome components at the plasma membrane.
Title: Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp.
Title: Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity.
Targeting of integrin beta1 and kinesin 2alpha by microRNA 183.
Title: Targeting of integrin beta1 and kinesin 2alpha by microRNA 183.
Data show that Kif2a is regulated positively by Plk1 and negatively by Aurora A, and suggest that this antagonistic regulation confers differential stability to microtubules in the spindle versus at the pole versus in the cytosol.
Title: Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a.
DDA3 interacts with the MT depolymerase Kif2a in an microtubule-dependent manner and recruits Kif2a to the mitotic spindle and spindle poles.
Title: DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement.
Observational study of gene-disease association. (HuGE Navigator)
Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
kinesin-1, but not kinesin-2, contributes to the specific cytoplasmic distribution of three of the four steps of VV morphogenesis tested.
Title: Kinesin-1 plays multiple roles during the vaccinia virus life cycle.
These data demonstrate that Kif2b function is required for spindle assembly and chromosome movement and that the microtubule depolymerase activities of Kif2a, Kif2b, and MCAK fulfill distinct functions during mitosis in human cells.
Title: The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.
Kif2a has a role in bipolar spindle assembly along with MCAK
Title: The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK.

Submit: New GeneRIF Correction See all (12)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
O00139	O94985	CLSTN1	HPRD	PubMed
O00139	Q07866	KLC1	HPRD	PubMed
O00139	Q9H0B6	KLC2	HPRD	PubMed
BioGRID:109997	BioGRID:109318	HDGF	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109997	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
microtubule motor activity	IEA Inferred from Electronic Annotation more info
motor activity	TAS Traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
M phase of mitotic cell cycle	TAS Traceable Author Statement more info
blood coagulation	TAS Traceable Author Statement more info
cell differentiation	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
microtubule-based movement	TAS Traceable Author Statement more info
mitotic cell cycle	TAS Traceable Author Statement more info
mitotic prometaphase	TAS Traceable Author Statement more info
mitotic spindle organization	IDA Inferred from Direct Assay more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
centrosome	IDA Inferred from Direct Assay more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
colocalizes_with spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: kinesin-like protein KIF2A

Names: kinesin-like protein KIF2A; kinesin-2; Kinesin, heavy chain, 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098511.2 → NP_001091981.1 kinesin-like protein KIF2A isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes the longest isoform (2).

Source sequence(s)

AC016637, AI652174, DB456309, EF560716

Consensus CDS

CCDS47216.1

UniProtKB/Swiss-Prot

O00139

Related

ENSP00000385000, OTTHUMP00000197299, ENST00000407818, OTTHUMT00000317988

Conserved Domains (1) summary

cd01367
Location:222 – 551
Blast Score: 1293

KISc_KIF2_like; Kinesin motor domain, KIF2-like group. KIF2 is a protein expressed in neurons, which has been associated with axonal transport and neuron development; alternative splice forms have been implicated in lysosomal translocation. This catalytic (head) domain ...
NM_001243952.1 → NP_001230881.1 kinesin-like protein KIF2A isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 2. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 2.

Source sequence(s)

AC016637, AI652174, BC047544, DB456309

UniProtKB/TrEMBL

E9PB70

Conserved Domains (1) summary

cd01367
Location:202 – 531
Blast Score: 1292

KISc_KIF2_like; Kinesin motor domain, KIF2-like group. KIF2 is a protein expressed in neurons, which has been associated with axonal transport and neuron development; alternative splice forms have been implicated in lysosomal translocation. This catalytic (head) domain ...
NM_001243953.1 → NP_001230882.1 kinesin-like protein KIF2A isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 3' end of an exon and lacks an alternate in-frame exon compared to isoform 2. The resulting isoform (4) has the same N- and C-termini but lacks two alternate internal segments compared to isoform 2.

Source sequence(s)

AC016637, AI652174, AK315866, DB452624, DB456309

UniProtKB/TrEMBL

B0AZS5

Conserved Domains (1) summary

cd01367
Location:203 – 532
Blast Score: 1289

KISc_KIF2_like; Kinesin motor domain, KIF2-like group. KIF2 is a protein expressed in neurons, which has been associated with axonal transport and neuron development; alternative splice forms have been implicated in lysosomal translocation. This catalytic (head) domain ...
NM_004520.4 → NP_004511.2 kinesin-like protein KIF2A isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 2.

Source sequence(s)

AC016637, AI652174, DB456309, EF560728

Consensus CDS

CCDS3980.2

UniProtKB/Swiss-Prot

O00139

Related

ENSP00000385622, OTTHUMP00000197300, ENST00000401507, OTTHUMT00000317989

Conserved Domains (1) summary

cd01367
Location:222 – 551
Blast Score: 1292

KISc_KIF2_like; Kinesin motor domain, KIF2-like group. KIF2 is a protein expressed in neurons, which has been associated with axonal transport and neuron development; alternative splice forms have been implicated in lysosomal translocation. This catalytic (head) domain ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

61601989..61682210

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

58558087..58638664

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC016637.7 (19139..59184)	None
genomic	AC034242.6	None
genomic	CH471137.2	EAW51387.1
		EAW51388.1
		EAW51389.1
		EAW51390.1
mRNA	AI652174.1	None
mRNA	AK297347.1	BAG59797.1
mRNA	AK302270.1	BAG63616.1
mRNA	AK307880.1	None
mRNA	AK315866.1	BAF98757.1
mRNA	AY317140.1	AAP84320.1
mRNA	AY429552.1	None
mRNA	BC031828.2	AAH31828.1
mRNA	BC047544.1	None
mRNA	DB452624.1	None
mRNA	DB456309.1	None
mRNA	EF560716.1	ABQ59026.1
mRNA	EF560728.1	ABQ59038.1
mRNA	Y08319.1	CAA69621.1
other-genetic	DQ891347.2	ABM82273.1
other-genetic	DQ894527.2	ABM85453.1
other-genetic	EU832810.1	ACE87821.1
other-genetic	GQ129246.1	ACT64380.1