Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

KEL Kell blood group, metallo-endopeptidase [ Homo sapiens (human) ]

Gene ID: 3792, updated on 12-Apr-2014
Official Symbol
KELprovided by HGNC
Official Full Name
Kell blood group, metallo-endopeptidaseprovided by HGNC
Primary source
HGNC:6308
See related
Ensembl:ENSG00000197993; HPRD:00194; MIM:613883; Vega:OTTHUMG00000157159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECE3; CD238
Summary
This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]
Location :
7q33
Sequence :
Chromosome: 7; NC_000007.14 (142941114..142962416, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily V, member 5 Neighboring gene chromosome 7 open reading frame 34 Neighboring gene olfactory receptor, family 9, subfamily A, member 2 Neighboring gene olfactory receptor, family 9, subfamily P, member 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of Kell blood group, metallo-endopeptidase (KEL) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
vasoconstriction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
kell blood group glycoprotein
Names
kell blood group glycoprotein
kell blood group antigen
NP_000411.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007492.1 RefSeqGene

    Range
    5001..26303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000420.2NP_000411.1  kell blood group glycoprotein

    See proteins identical to NP_000411.1

    Status: REVIEWED

    Source sequence(s)
    BC003135
    Consensus CDS
    CCDS34766.1
    UniProtKB/Swiss-Prot
    P23276
    Related
    ENSP00000347409, OTTHUMP00000211578, ENST00000355265, OTTHUMT00000347671
    Conserved Domains (2) summary
    cd08662
    Location:97730
    Blast Score: 1216
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:94732
    Blast Score: 535
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_187562.1

    Range
    964181..985483, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005276988.1XP_005277045.1  

    See proteins identical to XP_005277045.1

    Conserved Domains (2) summary
    cd08662
    Location:109742
    Blast Score: 1216
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:106744
    Blast Score: 535
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
  2. XM_005276989.2XP_005277046.1  

    See proteins identical to XP_005277046.1

    Conserved Domains (1) summary
    cd08662
    Location:1421
    Blast Score: 904
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  3. XM_005276990.2XP_005277047.1  

    See proteins identical to XP_005277047.1

    Conserved Domains (1) summary
    cd08662
    Location:17386
    Blast Score: 830
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14

    Range
    142941114..142962416, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249993.1XP_005250050.1  

    See proteins identical to XP_005250050.1

    Conserved Domains (2) summary
    cd08662
    Location:109742
    Blast Score: 1216
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:106744
    Blast Score: 535
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
  2. XM_005249994.2XP_005250051.1  

    See proteins identical to XP_005250051.1

    Conserved Domains (1) summary
    cd08662
    Location:1421
    Blast Score: 904
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  3. XM_005249995.2XP_005250052.1  

    See proteins identical to XP_005250052.1

    Conserved Domains (1) summary
    cd08662
    Location:17386
    Blast Score: 830
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

Alternate HuRef

Genomic

  1. AC_000139.1 Alternate HuRef

    Range
    136976490..136997792, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    142575086..142596388, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...