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KCNS1 potassium voltage-gated channel modifier subfamily S member 1 [ Homo sapiens (human) ]

Gene ID: 3787, updated on 29-Jun-2016
Official Symbol
KCNS1provided by HGNC
Official Full Name
potassium voltage-gated channel modifier subfamily S member 1provided by HGNC
Primary source
HGNC:HGNC:6300
See related
Ensembl:ENSG00000124134 HPRD:04214; MIM:602905; Vega:OTTHUMG00000033079
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Kv9.1
Summary
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]
Orthologs
Location:
20q12
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (45091214..45101112, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43720950..43729753, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene STK4 antisense RNA 1 (head to head) Neighboring gene serine/threonine kinase 4 Neighboring gene WAP four-disulfide core domain 5 Neighboring gene WAP four-disulfide core domain 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.
NHGRI GWA Catalog
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Voltage gated Potassium channels, organism-specific biosystem (from REACTOME)
    Voltage gated Potassium channels, organism-specific biosystemVoltage-gated K+ channels (Kv) determine the excitability of heart, brain and skeletal muscle cells. Kv form octameric channel with alpha subunits that forms the pore of the channel and associated be...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
potassium voltage-gated channel subfamily S member 1
Names
delayed-rectifier K(+) channel alpha subunit 1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
potassium voltage-gated channel, modifier subfamily S, member 1
voltage-gated potassium channel subunit Kv9.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322799.1NP_001309728.1  potassium voltage-gated channel subfamily S member 1

    Status: REVIEWED

    Source sequence(s)
    AK289735, CA449742, Z93016
    UniProtKB/Swiss-Prot
    Q96KK3
    UniProtKB/TrEMBL
    A2RUL8
    Related
    ENSP00000445595, ENST00000537075
    Conserved Domains (3) summary
    pfam00520
    Location:275456
    Ion_trans; Ion transport protein
    pfam02214
    Location:52151
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383457
    Ion_trans_2; Ion channel
  2. NM_002251.4NP_002242.2  potassium voltage-gated channel subfamily S member 1

    See identical proteins and their annotated locations for NP_002242.2

    Status: REVIEWED

    Source sequence(s)
    AF043473, CA449742, Z93016
    Consensus CDS
    CCDS13342.1
    UniProtKB/Swiss-Prot
    Q96KK3
    UniProtKB/TrEMBL
    A2RUL8
    Related
    ENSP00000307694, OTTHUMP00000031783, ENST00000306117, OTTHUMT00000080507
    Conserved Domains (3) summary
    pfam00520
    Location:275456
    Ion_trans; Ion transport protein
    pfam02214
    Location:52151
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383457
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

    Range
    45091214..45101112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027846.1XP_016883335.1  

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    43622602..43632500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)