KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 [Homo sapiens] - Gene

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Summary

Official Symbol: KCNN4provided by HGNC
Official Full Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4provided by HGNC
Primary source: HGNC:6293
See related: Ensembl:ENSG00000104783; HPRD:04130; MIM:602754
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IK1; SK4; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1
Summary: The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 19q13.2

Sequence :: Chromosome: 19; NC_000019.9 (44270685..44285409, complement)

See KCNN4 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study focussed on the endocytic internalization and the intracellular transport of the human isoform hK(Ca)3.1.
Title: Dynamic redistribution of calcium sensitive potassium channels (hK(Ca)3.1) in migrating cells.
PRL-3 promoted the proliferation of LoVo cells through upregulation of KCNN4 channels which facilitated the G2/M transition.
Title: PRL-3 promotes the proliferation of LoVo cells via the upregulation of KCNN4 channels.
The K(+) channel K(Ca)3.1 plays a key role in human fibrocyte migration
Title: Functional KCa3.1 K+ channels are required for human fibrocyte migration.
hypoxic exercise training this intervention depresses Gardos channel-modulated erythrocyte rheological functions
Title: Hypoxic exercise training causes erythrocyte senescence and rheological dysfunction by depressed Gardos channel activity.
the N-terminal domain of K(Ca)3.1 is critical for channel trafficking to the plasma membrane
Title: Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, K(Ca)3.1, in immune function of lymphoid cells.
Data suggest that human IK1-induced cell proliferation occurs by a direct interaction with ERK1/2 and JNK signaling pathways.
Title: Calcium-activated K+ channels increase cell proliferation independent of K+ conductance.
Results are consistent with the notion that human K(Ca)3.1 channels are assembled from two homomeric dimers and not randomly from four independent subunits.
Title: Dual-color quantum dot detection of a heterotetrameric potassium channel (hKCa3.1).
Intermediate conductance calcium-activated potassium channel mediates vasodilation together with nitric oxide and connexin 37 in mesenteric artery.
Title: Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide.
presence of mtKCa3.1 in tumor cell lines using biochemical and electrophysiological approaches
Title: An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1.
hKCa3.1 might contribute to breast tumour-progression and can serve as a useful prognostic marker for breast cancer.
Title: Intermediate conductance Ca2+ activated K+ channels are expressed and functional in breast adenocarcinomas: correlation with tumour grade and metastasis status.

Submit: New GeneRIF Correction See all (54)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
O15554	Calmodulin 1	CALM1	HPRD	PubMed
O15554	P54619	PRKAG1	HPRD	PubMed
BioGRID:109984	BioGRID:107252	CALM1	BioGRID	PubMed	Co-purification; Reconstituted Complex; Two-hybrid
BioGRID:109984	BioGRID:62106	Cam	BioGRID	PubMed	Reconstituted Complex
BioGRID:109984	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:109984	BioGRID:114555	USP8	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
calmodulin binding	IEA Inferred from Electronic Annotation more info
ion channel activity	IEA Inferred from Electronic Annotation more info
protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
small conductance calcium-activated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
cell volume homeostasis	IEA Inferred from Electronic Annotation more info
defense response	TAS Traceable Author Statement more info	PubMed
ion transport	IEA Inferred from Electronic Annotation more info
phospholipid translocation	IEA Inferred from Electronic Annotation more info
positive regulation of T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
potassium ion transport	IEA Inferred from Electronic Annotation more info
saliva secretion	IEA Inferred from Electronic Annotation more info
stabilization of membrane potential	IDA Inferred from Direct Assay more info	PubMed
synaptic transmission	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info
voltage-gated potassium channel complex	IC Inferred by Curator more info	PubMed

General protein information

Preferred Names: intermediate conductance calcium-activated potassium channel protein 4

Names: intermediate conductance calcium-activated potassium channel protein 4; SKCa4; SKCa 4; putative Gardos channel; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002250.2 → NP_002241.1 intermediate conductance calcium-activated potassium channel protein 4

Status: REVIEWED

Source sequence(s)

AF022797

Consensus CDS

CCDS12630.1

UniProtKB/Swiss-Prot

O15554

Related

ENSP00000262888, ENST00000262888

Conserved Domains (3) summary

pfam03530
Location:20 – 129
Blast Score: 393

SK_channel; Calcium-activated SK potassium channel

cl03763
Location:304 – 376
Blast Score: 300

CaMBD; Calmodulin binding domain

cl11596
Location:220 – 278
Blast Score: 142

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

44270685..44285409, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

40702891..40717615, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	A95651.1	CAB70490.1
genomic	AC115522.2 (6194..20918)	None
genomic	AF305731.1	AAG26917.1
genomic	AF305735.1	AAG26917.1
genomic	CH471126.1	EAW57229.1
		EAW57230.1
genomic	HC874393.1	CBM42811.1
mRNA	AB128983.1	BAI52725.1
mRNA	AB128984.1	BAI52726.1
mRNA	AB128985.1	BAI52727.1
mRNA	AF000972.1	AAB82739.1
mRNA	AF022150.1	AAC23541.1
mRNA	AF022797.1	AAC51913.1
mRNA	AF033021.1	AAC36804.1
mRNA	AF053403.1	AAC35281.1
mRNA	AF395661.1	AAK81862.1
mRNA	BC015337.1	AAH15337.1
mRNA	BT007426.1	AAP36094.1
other-genetic	DQ891493.2	ABM82419.1
other-genetic	DQ894684.2	ABM85610.1