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KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 [ Homo sapiens (human) ]

Gene ID: 3783, updated on 19-Oct-2014
Official Symbol
KCNN4provided by HGNC
Official Full Name
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4provided by HGNC
Primary source
HGNC:HGNC:6293
See related
Ensembl:ENSG00000104783; HPRD:04130; MIM:602754; Vega:OTTHUMG00000182779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IK1; SK4; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1
Summary
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
See KCNN4 in Epigenomics, MapViewer
Location:
19q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (43766533..43782117, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44270685..44286269, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene immunity-related GTPase family, cinema Neighboring gene SMG9 nonsense mediated mRNA decay factor Neighboring gene LY6/PLAUR domain containing 5 Neighboring gene zinc finger protein 283

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

  • Ca2+ activated K+ channels, organism-specific biosystem (from REACTOME)
    Ca2+ activated K+ channels, organism-specific biosystemCa2+ activated potassium channels are expressed in neuronal and non-neuronal tissue such as smooth muscle, epithelial cell and sensory cells. Ca2+ activated potassium channels are activated when the ...
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Protein digestion and absorption, organism-specific biosystem (from KEGG)
    Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Protein digestion and absorption, conserved biosystem (from KEGG)
    Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Intermediate conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT small conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
cell volume homeostasis IEA
Inferred from Electronic Annotation
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
phospholipid translocation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
potassium ion export IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
saliva secretion IEA
Inferred from Electronic Annotation
more info
 
stabilization of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
synaptic transmission TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IC
Inferred by Curator
more info
PubMed 
Preferred Names
intermediate conductance calcium-activated potassium channel protein 4
Names
intermediate conductance calcium-activated potassium channel protein 4
SKCa4
SKCa 4
putative Gardos channel
putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002250.2NP_002241.1  intermediate conductance calcium-activated potassium channel protein 4

    See proteins identical to NP_002241.1

    Status: REVIEWED

    Source sequence(s)
    AF022797
    Consensus CDS
    CCDS12630.1
    UniProtKB/Swiss-Prot
    O15554
    Related
    ENSP00000262888, OTTHUMP00000270147, ENST00000262888, OTTHUMT00000463598
    Conserved Domains (3) summary
    pfam02888
    Location:304376
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:11129
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:237286
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    43766533..43782117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258886.1XP_005258943.1  

    Conserved Domains (3) summary
    pfam02888
    Location:128200
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:1155
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:61110
    Ion_trans_2; Ion channel
  2. XM_005258882.1XP_005258939.1  

    Conserved Domains (3) summary
    pfam02888
    Location:272344
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:1197
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:205254
    Ion_trans_2; Ion channel
  3. XM_005258883.1XP_005258940.1  

    Conserved Domains (2) summary
    pfam02888
    Location:241313
    CaMBD; Calmodulin binding domain
    pfam07885
    Location:174223
    Ion_trans_2; Ion channel

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    40702891..40717615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    44272786..44287492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)