KCNN1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 [Homo sapiens] - Gene

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Summary

Official Symbol: KCNN1provided by HGNC
Official Full Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1provided by HGNC
Primary source: HGNC:6290
See related: Ensembl:ENSG00000105642; HPRD:04282; MIM:602982
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SK1; hSK1; SKCA1; KCa2.1
Summary: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 19p13.1

Sequence :: Chromosome: 19; NC_000019.9 (18062111..18109930)

See KCNN1 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Decreased expression of small-conductance Ca2+-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation.
Title: Decreased expression of small-conductance Ca2+-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation.
IK1-like immunoreactivity is observed in enteric neurons of human colon, with a significant decrease of IK1-positive cells in inflamed colon from patients with Crohn's disease and ulcerative colitis.
Title: Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:109981	BioGRID:113164	UBC		BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
calcium-activated potassium channel activity	TAS Traceable Author Statement more info	PubMed
calmodulin binding	IEA Inferred from Electronic Annotation more info
ion channel activity	IEA Inferred from Electronic Annotation more info
potassium channel activity	TAS Traceable Author Statement more info
small conductance calcium-activated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
ion transport	IEA Inferred from Electronic Annotation more info
potassium ion transmembrane transport	TAS Traceable Author Statement more info
potassium ion transport	IEA Inferred from Electronic Annotation more info
synaptic transmission	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info
voltage-gated potassium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: small conductance calcium-activated potassium channel protein 1

Names: small conductance calcium-activated potassium channel protein 1; SKCa 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029893.1 RefSeqGene

Range

5001..52820

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002248.3 → NP_002239.2 small conductance calcium-activated potassium channel protein 1

Status: REVIEWED

Source sequence(s)

BE504989, U69883

UniProtKB/Swiss-Prot

Q92952

Related

ENSP00000222249, ENST00000222249

Conserved Domains (3) summary

pfam03530
Location:92 – 210
Blast Score: 554

SK_channel; Calcium-activated SK potassium channel

cl03763
Location:384 – 461
Blast Score: 351

CaMBD; Calmodulin binding domain

cl11596
Location:294 – 366
Blast Score: 152

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

18062111..18109930

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

17627350..17675149

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005602.1 (23900..29218)	None
genomic	AC020904.7 (2487..44987)	None
genomic	AF131948.1	AAD37507.1
genomic	CH471106.1	EAW84646.1
		EAW84647.1
mRNA	AB198191.1	BAD86831.1
mRNA	AK298170.1	BAG60442.1
mRNA	BC075037.2	AAH75037.3
mRNA	BE504989.1	None
mRNA	U69883.2	AAB09562.1