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KCNK3 potassium channel, two pore domain subfamily K, member 3 [ Homo sapiens (human) ]

Gene ID: 3777, updated on 5-Apr-2015
Official Symbol
KCNK3provided by HGNC
Official Full Name
potassium channel, two pore domain subfamily K, member 3provided by HGNC
Primary source
HGNC:HGNC:6278
See related
HPRD:04451; MIM:603220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OAT1; PPH4; TASK; TBAK1; K2p3.1; TASK-1
Summary
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]
Orthologs
See KCNK3 in MapViewer
Location:
2p23
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (26692713..26731198)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26915581..26954066)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene chromosome 2 open reading frame 70 Neighboring gene calcium and integrin binding family member 4 Neighboring gene ribosomal protein L37 pseudogene 11 Neighboring gene solute carrier family 35, member F6 Neighboring gene centromere protein A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu and TASK-1 decrease HIV-1 transcription by suppressing unintegrated HIV-1 DNA, which is inhibited by overexpression of RelA PubMed
vpu HIV-1 Vpu interacts with TASK-1, a mammalian background K(+) channel, which in turn suppresses TASK-1 current in HEK-293 cells PubMed

Go to the HIV-1, Human Interaction Database

  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Nicotine Activity on Dopaminergic Neurons, organism-specific biosystem (from WikiPathways)
    Nicotine Activity on Dopaminergic Neurons, organism-specific biosystemNicotine is an alkaloid found in tobacco plants. It is a substance that acts as a stimulant in humans and is one of the main factors responsible for tobacco dependence. When nicotine enters the body,...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • TWIK-releated acid-sensitive K+ channel (TASK), organism-specific biosystem (from REACTOME)
    TWIK-releated acid-sensitive K+ channel (TASK), organism-specific biosystemTASK 1 and 3 are closely related both structurally and functionally. TASK1 and TASK3 are activated by extracellular acidification and inhibited by decrease in pH. TASK 1 and Task 3 form functional ho...
  • Tandem pore domain potassium channels, organism-specific biosystem (from REACTOME)
    Tandem pore domain potassium channels, organism-specific biosystemTandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mech...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
open rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
potassium ion leak channel activity IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of mitophagy in response to mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to zinc ion IEA
Inferred from Electronic Annotation
more info
 
cochlea development IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
potassium channel subfamily K member 3
Names
potassium channel subfamily K member 3
TWIK-related acid-sensitive K(+) channel 1
TWIK-related acid-sensitive K+ channel
acid-sensitive potassium channel protein TASK
acid-sensitive potassium channel protein TASK-1
cardiac potassium channel
potassium inwardly-rectifying channel, subfamily K, member 3
two P domain potassium channel
two pore K(+) channel KT3.1
two pore potassium channel KT3.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033884.1 RefSeqGene

    Range
    5001..43486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002246.2NP_002237.1  potassium channel subfamily K member 3

    See identical proteins and their annotated locations for NP_002237.1

    Status: REVIEWED

    Source sequence(s)
    AC015977, AF065163
    Consensus CDS
    CCDS1727.1
    UniProtKB/Swiss-Prot
    O14649
    Conserved Domains (1) summary
    pfam07885
    Location:77129
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    26692713..26731198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264293.1XP_005264350.1  

    Conserved Domains (1) summary
    pfam07885
    Location:57133
    Ion_trans_2; Ion channel

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    26845436..26883789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)