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Ssrp Structure specific recognition protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37767, updated on 11-Apr-2024

Summary

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Official Symbol
Ssrpprovided by FlyBase
Official Full Name
Structure specific recognition proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0010278
Locus tag
Dmel_CG4817
See related
AllianceGenome:FB:FBgn0010278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cf5; CG4817; Dmel\CG4817; dSsrp; dSSRP; DssRP; dSSRP1; ssrp; SSRP; SSRP1
Summary
Enables nucleosomal DNA binding activity and protein self-association. Involved in several processes, including negative regulation of protein phosphorylation; ovarian follicle cell development; and positive regulation of actin filament polymerization. Located in nucleolus. Part of FACT complex. Is expressed in several structures, including embryonic brain; extended germ band embryo; gut section; larval ventral nerve cord; and ovary. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
60A2-60A2; 2-105 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23806361..23809004, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19693884..19696527, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44807 Neighboring gene NTF2-related export protein 1 Neighboring gene pippin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solution structure of the HMG-box domain in the SSRP1 subunit of FACT. Kasai N, et al. J Biomol NMR, 2005 May. PMID 16041486
  2. Isolation and characterization of cDNA clones encoding the Drosophila homolog of the HMG-box SSRP family that recognizes specific DNA structures. Bruhn SL, et al. Nucleic Acids Res, 1993 Apr 11. PMID 8479916, Free PMC Article
  3. A Drosophila single-strand DNA/RNA-binding factor contains a high-mobility-group box and is enriched in the nucleolus. Hsu T, et al. Proc Natl Acad Sci U S A, 1993 Jul 15. PMID 7688122, Free PMC Article
  4. Ultrasensitive Change in Nucleosome Binding by Multiple Phosphorylations to the Intrinsically Disordered Region of the Histone Chaperone FACT. Aoki D, et al. J Mol Biol, 2020 Jul 24. PMID 32553729
  5. A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing. Tettey TT, et al. Cell Rep, 2019 Jun 25. PMID 31242411

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. alternatively spliced isoforms control self-renewal in neuroblast lineages
    Title: Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.
  2. rapid chromatin transactions during early embryogenesis through the dephosphorylation of some sites in the maternally transmitted dSSRP1
    Title: Phosphorylated intrinsically disordered region of FACT masks its nucleosomal DNA binding elements.
  3. Study shows that the GAGA factor-FACT complex and its binding site just downstream from the white gene are crucial for position effect variegation.
    Title: Drosophila GAGA factor directs histone H3.3 replacement that prevents the heterochromatin spreading.
  4. Results report the solution structure of the HMG-box domain in Drosophila SSRP1.
    Title: Solution structure of the HMG-box domain in the SSRP1 subunit of FACT.
  5. results show that FACT, a heterodimer of dSPT16 and dSSRP1, associates with GAGA factor through its dSSRP1 subunit & facilitates chromatin remodeling; interactions between GAGA factor and spt16 implicate the GAGA factor-FACT complex in Hox gene expression
    Title: Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromo shadow domain binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosomal DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of FACT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of FACT complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with polytene chromosome puff IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
structure specific recognition protein
Names
CG4817-PA
Ssrp-PA
chorion factor
structure-specific recognition protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23806361..23809004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079106.3 → NP_523830.2  structure specific recognition protein [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523830.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q05344, Q86NM5, Q9W1J4
    UniProtKB/TrEMBL
    B5RJ65
    Related
    FBpp0072151
    Conserved Domains (4) summary
    COG5165
    Location:20 → 499
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    cd13231
    Location:332 → 427
    PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2
    pfam00505
    Location:557 → 620
    HMG_box; HMG (high mobility group) box
    pfam03531
    Location:75 → 284
    SSrecog; Structure-specific recognition protein (SSRP1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05344.2 Q05344

Gene LinkOut

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