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CG30183 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37749, updated on 4-Apr-2024

Summary

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Official Symbol
CG30183provided by FlyBase
Primary source
FLYBASE:FBgn0050183
Locus tag
Dmel_CG30183
See related
AllianceGenome:FB:FBgn0050183
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4093; CG4530; Dmel\CG30183
Summary
Predicted to enable actin binding activity. Predicted to be involved in actomyosin contractile ring assembly; mitotic cytokinesis; and septin ring organization. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be active in actomyosin contractile ring. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
59F6-59F6; 2-104 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23690247..23697824, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19577770..19585347, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Sulfotransferase 1 Neighboring gene Sulfotransferase 3 Neighboring gene lethal (2) essential for life Neighboring gene Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2 Neighboring gene angel Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene salivary glands marred Neighboring gene lethal-(2)-denticleless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Animal Cell Cytokinesis: The Rho-Dependent Actomyosin-Anilloseptin Contractile Ring as a Membrane Microdomain Gathering, Compressing, and Sorting Machine. Carim SC, et al. Front Cell Dev Biol, 2020. PMID 33117802, Free PMC Article
  2. Deadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects. Temme C, et al. Front Genet, 2014. PMID 24904643, Free PMC Article
  3. A cell atlas of the adult Drosophila midgut. Hung RJ, et al. Proc Natl Acad Sci U S A, 2020 Jan 21. PMID 31915294, Free PMC Article
  4. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article
  5. In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry. Rees JS, et al. Mol Cell Proteomics, 2011 Jun. PMID 21447707, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in actomyosin contractile ring assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in septin ring organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in actomyosin contractile ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG30183-PA
CG30183-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23690247..23697824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144273.2 → NP_001137745.2  uncharacterized protein Dmel_CG30183, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137745.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZP5, Q86NU0, Q9W1L2
    Conserved Domains (2) summary
    cd01263
    Location:1438 → 1549
    PH_anillin; Anillin Pleckstrin homology (PH) domain
    pfam00169
    Location:1442 → 1546
    PH; PH domain

  2. NM_137975.3 → NP_611819.2  uncharacterized protein Dmel_CG30183, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611819.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZP5, Q86NU0, Q9W1L2
    Conserved Domains (2) summary
    cd01263
    Location:1438 → 1549
    PH_anillin; Anillin Pleckstrin homology (PH) domain
    pfam00169
    Location:1442 → 1546
    PH; PH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86NU0 Q86NU0
Q9W1L2 Q9W1L2

Gene LinkOut

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