Dcp-1 Death caspase-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

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Official Symbol: Dcp-1provided by FlyBase
Official Full Name: Death caspase-1provided by FlyBase
Primary source: FLYBASE:FBgn0010501
Locus tag: Dmel_CG5370
Gene type: protein coding
RNA name: death caspase-1
RefSeq status: REVIEWED
Organism: Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ccp1; CG5370; dcp-1; DCP-1; dcp1; Dcp1; DCP1; Dmel\CG5370; l(2)01862; l(2)02132

Genomic context

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Location :: 59E3-59E3

Sequence :: Chromosome: 2R; NT_033778.3 (19438838..19441079)

See Dcp-1 in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1, and ice
Title: Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis.
Autophagy suppresses Dcp-1-mediated apoptotic cell death, whereas Dcp-1 positively regulates autophagy, possibly through feedback regulation.
Title: A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes.
HeT-A mRNA is derepressed in mRNA degradation mutants dcp1, indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.
Title: piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline.
Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death in Drosophila.
Title: Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis.
A double-mutant analysis between drICE and death caspase-1 (dcp-1), another effector caspase, reveals that some cells (type I) strictly require drICE for apoptosis, whereas other cells (type II) require either drICE or dcp-1.
Title: The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila.
novel characteristic morphological features of egg chambers lacking both dcp-1 and pita functions in the germline cells; suggested an essential role of dcp-1 and/or pita during mid-oogenesis
Title: Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesis.

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Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_476974.1	NP_524101.2	th	BIND	PubMed	DIAP1 interacts with DCP-1.
BioGRID:63329	BioGRID:62614	Ark	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63329	BioGRID:65293	W	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63329	BioGRID:65298	grim	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63329	BioGRID:65299	rpr	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63329	BioGRID:65064	th	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Suppression

Pathways from BioSystems

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Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
Apoptotic cleavage of cellular proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptotic execution phase, organism-specific biosystem (from REACTOME)
Apoptotic execution phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Breakdown of the nuclear lamina, organism-specific biosystem (from REACTOME)
Breakdown of the nuclear lamina, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

Dm0623 (e-PCR)
- UniSTS:50079

Homology

Homologs of the Dcp-1 gene: The Dcp-1 gene is conserved in human, chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, zebrafish, and mosquito.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info
cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cysteine-type endopeptidase activity	NAS Non-traceable Author Statement more info	PubMed
cysteine-type endopeptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
actin filament organization	TAS Traceable Author Statement more info	PubMed
apoptotic process	IDA Inferred from Direct Assay more info
apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic process	TAS Traceable Author Statement more info	PubMed
autophagic cell death	IEP Inferred from Expression Pattern more info	PubMed
cleavage of lamin involved in execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
cytoplasmic transport, nurse cell to oocyte	TAS Traceable Author Statement more info	PubMed
developmental programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
multicellular organismal development	TAS Traceable Author Statement more info	PubMed
negative regulation of neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info
neuron remodeling	IMP Inferred from Mutant Phenotype more info
nurse cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
nurse cell apoptotic process	TAS Traceable Author Statement more info	PubMed
ovarian nurse cell to oocyte transport	IMP Inferred from Mutant Phenotype more info	PubMed
ovarian nurse cell to oocyte transport	TAS Traceable Author Statement more info	PubMed
programmed cell death	IDA Inferred from Direct Assay more info
proteolysis	TAS Traceable Author Statement more info	PubMed
salivary gland cell autophagic cell death	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: CG5370 gene product from transcript CG5370-RA

Names: CG5370-PA; Dcp-1-PA; caspase; caspase 1; caspase-1; death caspase-1

NP_476974.1

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

19438838..19441079

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057626.3 → NP_476974.1 death caspase-1 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

O02002

Related

FBpp0071971, FBtr0072062

Conserved Domains (1) summary

cd00032
Location:71 – 313
Blast Score: 763

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...