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KCNJ15 potassium voltage-gated channel subfamily J member 15 [ Homo sapiens (human) ]

Gene ID: 3772, updated on 10-May-2016
Official Symbol
KCNJ15provided by HGNC
Official Full Name
potassium voltage-gated channel subfamily J member 15provided by HGNC
Primary source
HGNC:HGNC:6261
See related
Ensembl:ENSG00000157551 HPRD:03659; MIM:602106; Vega:OTTHUMG00000090609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRKK; KIR1.3; KIR4.2
Summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]
Orthologs
Location:
21q22.2
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 21 NC_000021.9 (38229915..38303126)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (39601837..39675043)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene cutaneous T-cell lymphoma-associated antigen 1 pseudogene Neighboring gene uncharacterized LOC105372801 Neighboring gene Down syndrome critical region 10 (non-protein coding) Neighboring gene uncharacterized LOC105372800 Neighboring gene spermatogenesis associated 20 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1423 Neighboring gene ERG, ETS transcription factor Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 13

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Activation of G protein gated Potassium channels, organism-specific biosystem (from REACTOME)
    Activation of G protein gated Potassium channels, organism-specific biosystemActivation of Kir 3 channels occurs after binding of G beta gamma subunits of GPCR. Activation of Kir3/GIRK leads to K+ efflux. The dissociation of GPCR into G alpha and G beta gamma subunits is acti...
  • Activation of GABAB receptors, organism-specific biosystem (from REACTOME)
    Activation of GABAB receptors, organism-specific biosystemGABA B receptors are metabotropic receptors that are functionally linked to C type G protein coupled receptors.? GABA B receptors are activated upon ligand binding. The GABA B1 subunit binds ligand a...
  • G protein gated Potassium channels, organism-specific biosystem (from REACTOME)
    G protein gated Potassium channels, organism-specific biosystemInwardly rectifying G protein activated K+ channels (GIRK) are tetrameric assemblies of Ki3 3 family subunits (Kir 3.1, 3.2 3.3 and 3.4). The activation of G protein coupled receptor by ligand result...
  • GABA B receptor activation, organism-specific biosystem (from REACTOME)
    GABA B receptor activation, organism-specific biosystemFunctional GABA B receptors are heteromers of GABA B1 and B2 subunits, complexed with G protein alpha-i, 0, beta, and gamma subunits. They function as metabotropic receptors. When GABA is bound to th...
  • GABA receptor activation, organism-specific biosystem (from REACTOME)
    GABA receptor activation, organism-specific biosystemGamma aminobutyric acid (GABA) receptors are the major inhibitory receptors in human synapses. They are of two types. GABA A receptors are fast-acting ligand gated chloride ion channels that mediate ...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, organism-specific biosystem (from REACTOME)
    Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, organism-specific biosystemGABA B receptors are coupled to Gproteins and function by increasing the K+ and decreasing the Ca2+ inside the cell. The increase in K+ increases the negative membrane potential of the cell thereby h...
  • Inwardly rectifying K+ channels, organism-specific biosystem (from REACTOME)
    Inwardly rectifying K+ channels, organism-specific biosystemInwardly rectifying K+ channels (Kir channels) show an inward rather than outward (like the voltage gated K+ channels) flow of K+ thereby contributing to maintenance of resting membrane potential an...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC13584

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein activated inward rectifier potassium channel activity TAS
Traceable Author Statement
more info
 
inward rectifier potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
potassium ion import IBA
Inferred from Biological aspect of Ancestor
more info
 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
ATP-sensitive inward rectifier potassium channel 15
Names
inward rectifier K(+) channel Kir1.3
inward rectifier K(+) channel Kir4.2
inward rectifier K+ channel KIR4.2
potassium channel, inwardly rectifying subfamily J member 15
potassium channel, inwardly rectifying subfamily J, member 15
potassium inwardly-rectifying channel, subfamily J, member 15

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276435.1NP_001263364.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263364.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction and contains two additional exons in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, BC013327, DA968871
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Related
    ENSP00000484960, ENST00000612702
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel
  2. NM_001276436.1NP_001263365.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction and contains two additional exons in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, BC013327, DA968871, DB232867
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Related
    ENSP00000479100, ENST00000613499
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel
  3. NM_001276437.1NP_001263366.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction and contains an additional exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, BC013327, DA670230, DA675388
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel
  4. NM_001276438.1NP_001263367.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate 5'-most exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, BC013327, DA673158, DA675388
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel
  5. NM_001276439.1NP_001263368.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice junction and contains an additional exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, BC013327, DA673158
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel
  6. NM_002243.4NP_002234.2  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_002234.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction and contains an additional exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, BC013327, DA968871
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Related
    ENSP00000331698, OTTHUMP00000115737, ENST00000328656, OTTHUMT00000207181
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel
  7. NM_170736.2NP_733932.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_733932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, BC013327, D87291, DB008463
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Related
    ENSP00000381911, OTTHUMP00000115738, ENST00000398938, OTTHUMT00000207182
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel
  8. NM_170737.2NP_733933.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_733933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5'-most exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, BC013327, DA632853
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Related
    ENSP00000381907, ENST00000398934
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p2 Primary Assembly

    Range
    38229915..38303126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529560.1XP_011527862.1  

    See identical proteins and their annotated locations for XP_011527862.1

    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel
  2. XM_011529561.1XP_011527863.1  

    See identical proteins and their annotated locations for XP_011527863.1

    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel
  3. XM_006724002.2XP_006724065.1  

    See identical proteins and their annotated locations for XP_006724065.1

    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel
  4. XM_005260975.2XP_005261032.1  

    See identical proteins and their annotated locations for XP_005261032.1

    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30365
    IRK; Inward rectifier potassium channel

Alternate CHM1_1.1

Genomic

  1. NC_018932.2 Alternate CHM1_1.1

    Range
    39162401..39234297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)