ARF3 ADP-ribosylation factor 3 [Homo sapiens] - Gene

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Summary

Official Symbol: ARF3provided by HGNC
Official Full Name: ADP-ribosylation factor 3provided by HGNC
Primary source: HGNC:654
See related: Ensembl:ENSG00000134287; HPRD:00056; MIM:103190; Vega:OTTHUMG00000168080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 12q13

Sequence :: Chromosome: 12; NC_000012.11 (49329992..49351252, complement)

See ARF3 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that Arf3 plays a unique function at the trans-Golgi network that likely involves recruitment by a specific receptor.
Title: Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
expression and subcellular redistribution by heregulin
Title: Heregulin promotes expression and subcellular redistribution of ADP-ribosylation factor 3.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001650.1		GGA1	BIND	PubMed	ARF3 (hArf3) interacts with an unspecified isoform of GGA1 (hGGA1).
P61204	P53367	ARFIP1	HPRD	PubMed
P61204	P53365	ARFIP2	HPRD	PubMed
P61204	P54259	ATN1	HPRD	PubMed
P61204	Q9UJY4	GGA2	HPRD	PubMed
P61204	Q02241	KIF23	HPRD	PubMed
P61204	Q9NRD5	PICK1	HPRD	PubMed
P61204	P14672	SLC2A4	HPRD	PubMed
BioGRID:106872	BioGRID:229294	2810046L04Rik	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106872	BioGRID:223223	AI837181	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106872	BioGRID:118084	ARFIP1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106872	BioGRID:117174	ARFIP2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106872	BioGRID:198294	Bach1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106872	BioGRID:117540	GGA1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106872	BioGRID:116697	GGA2	BioGRID	PubMed	Two-hybrid
BioGRID:106872	BioGRID:116775	GGA3	BioGRID	PubMed	Two-hybrid
BioGRID:106872	BioGRID:114873	KIF23	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106872	BioGRID:200937	Kif1c	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106872	BioGRID:204968	Mapk13	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106872	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	TAS Traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
GTP catabolic process	TAS Traceable Author Statement more info	PubMed
protein transport	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
intracellular	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: ADP-ribosylation factor 3

Names: ADP-ribosylation factor 3; small GTP binding protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001659.2 → NP_001650.1 ADP-ribosylation factor 3

Status: REVIEWED

Source sequence(s)

BC017565, BC028402, BM966960

Consensus CDS

CCDS8774.1

UniProtKB/Swiss-Prot

P61204

Related

ENSP00000256682, OTTHUMP00000165241, ENST00000256682, OTTHUMT00000258242

Conserved Domains (1) summary

cd04150
Location:18 – 176
Blast Score: 910

Arf1_5_like; ADP-ribosylation factor-1 (Arf1) and ADP-ribosylation factor-5 (Arf5)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

49329992..49351252, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

46361992..46383255, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC073610.17 (54279..75597)	None
genomic	CH471111.1	EAW58025.1
		EAW58026.1
		EAW58027.1
genomic	M74492.1	None
genomic	M74493.1	AAA58359.1
mRNA	AF493882.1	AAM12596.1
mRNA	AK291633.1	BAF84322.1
mRNA	AK303726.1	BAG64702.1
mRNA	AK316528.1	BAH14899.1
mRNA	BC007647.1	AAH07647.1
mRNA	BC007762.2	AAH07762.1
mRNA	BC017565.2	AAH17565.1
mRNA	BC028402.2	AAH28402.1
mRNA	BM966960.1	None
mRNA	BT006670.1	AAP35316.1
mRNA	M74491.1	AAB59425.1
other-genetic	EU832818.1	ACE87829.1
other-genetic	GQ129444.1	ACT64578.1