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    inaD inactivation no afterpotential D [ Drosophila melanogaster ]

    Gene ID: 37629, updated on 10-May-2012
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    Summary

    Official Symbol
    inaDprovided by Flybase
    Official Full Name
    inactivation no afterpotential Dprovided by Flybase
    Primary source
    FLYBASE:FBgn0001263
    Locus tag
    Dmel_CG3504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3504; Dmel\CG3504; Ina-D; InaD; INAD
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    Genomic context

    Location :
    59B3-59B3; 2-101 cM
    Sequence :
    Chromosome: 2R; NT_033778.3 (18743211..18746317, complement)
    See inaD in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG3649 gene product from transcript CG3649-RB Neighboring gene CG13531 gene product from transcript CG13531-RB Neighboring gene Ribosomal protein L23 Neighboring gene forkhead domain 59A Neighboring gene CG13532 gene product from transcript CG13532-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Liu W, et al. Cell, 2011 Jun 24. PMID 21703451.
    2. Dependence on a retinophilin/myosin complex for stability of PKC and INAD and termination of phototransduction. Venkatachalam K, et al. J Neurosci, 2010 Aug 25. PMID 20739554.
    3. A forward genetic screen in Drosophila melanogaster to identify mutations affecting INAD localization in photoreceptor cells. Sanxaridis PD, et al. Fly (Austin), 2010 Apr-Jun. PMID 20404479.
    4. Retinophilin is a light-regulated phosphoprotein required to suppress photoreceptor dark noise in Drosophila. Mecklenburg KL, et al. J Neurosci, 2010 Jan 27. PMID 20107052.
    5. Requirement for an enzymatic visual cycle in Drosophila. Wang X, et al. Curr Biol, 2010 Jan 26. PMID 20045325.

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Through biochemical and structural studies, study shows that the redox potential of PDZ5 is allosterically regulated by its interaction with another INAD domain, PDZ4.
      Title: The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye.
    2. genetic screen of the third chromosome for mutations that result in mislocalization of an INAD-GFP fusion protein
      Title: A forward genetic screen in Drosophila melanogaster to identify mutations affecting INAD localization in photoreceptor cells.
    3. TRP associates with INAD via its last 14 residues to facilitate its regulation by eye-PKC that fine-tunes the visual signaling
      Title: Anchoring TRP to the INAD macromolecular complex requires the last 14 residues in its carboxyl terminus.
    4. study demonstrates conformational switch mechanism for PDZ domain function & suggest INAD behaves more like a dynamic machine rather than a passive scaffold, regulating signal transduction through cycles of conformational change
      Title: Dynamic scaffolding in a G protein-coupled signaling system.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:63241 BioGRID:60738 A16    BioGRID  PubMed Two-hybrid 
    BioGRID:63241 BioGRID:66212 CG8136    BioGRID  PubMed Two-hybrid 
    BioGRID:63241 BioGRID:58753 CG9411    BioGRID  PubMed Two-hybrid 
    BioGRID:63241 BioGRID:60514 CHIP    BioGRID  PubMed Two-hybrid 
    BioGRID:63241 BioGRID:60772 Drep-4    BioGRID  PubMed Two-hybrid 
    BioGRID:63241 BioGRID:62158 Galpha49B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:63241 BioGRID:68008 RASSF8    BioGRID  PubMed Two-hybrid 
    BioGRID:63241 BioGRID:60577 Stam    BioGRID  PubMed Two-hybrid 
    BioGRID:63241 BioGRID:61158 hk    BioGRID  PubMed Two-hybrid 
    BioGRID:63241 BioGRID:62602 inaC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:63241 BioGRID:67356 ninaE    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:63241 BioGRID:57893 norpA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:63241 BioGRID:68399 trp    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Pathways from BioSystems

    • Phototransduction - fly, organism-specific biosystem (from KEGG)
      Phototransduction - fly, organism-specific biosystemPhototransduction is the process that converts the signal of light (photons) into a change of membrane potential in photoreceptor cells. Drosophila visual signaling is initiated with the activation o...
    • Phototransduction - fly, conserved biosystem (from KEGG)
      Phototransduction - fly, conserved biosystemPhototransduction is the process that converts the signal of light (photons) into a change of membrane potential in photoreceptor cells. Drosophila visual signaling is initiated with the activation o...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    myosin III binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    myosin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor signaling complex scaffold activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    deactivation of rhodopsin mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    detection of light stimulus involved in sensory perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    phototransduction IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    phototransduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    inaD signaling complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    inaD signaling complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    rhabdomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG3504 gene product from transcript CG3504-RA
    Names
    CG3504-PA
    CG3504-PB
    INAD
    inaD-PA
    inaD-PB
    inactivation no afterpotential D
    inactivation, no after-depolarization
    inactivation-no after potential D
    inactivation-no-afterpotential D
    inactivation-no-afterpotential-D
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      18743211..18746317, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166566.1 → NP_726260.1  inactivation no afterpotential D, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24008
      Related
      FBpp0071820, FBtr0071909
      Conserved Domains (1) summary
      cd00992
      Location:15 – 103
      Blast Score: 183
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. NM_001259541.1 → NP_001246470.1  inactivation no afterpotential D, isoform B [Drosophila melanogaster]

      Status: REVIEWED

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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAF46915.1
    mRNA U15803.1 AAC36490.1
    mRNA BT004473.1 AAO42637.1
    genomic AE013599.4 AFH08223.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24008.2 GenPept
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    Additional Links

    Gene LinkOut

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