CycB Cyclin B [Drosophila melanogaster] - Gene

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Summary

Official Symbol: CycBprovided by Flybase
Official Full Name: Cyclin Bprovided by Flybase
Primary source: FLYBASE:FBgn0000405
Locus tag: Dmel_CG3510
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2g; 3510; CG3510; cyc B; Cyc B; cyc-B; cycB; Cycb; CYCB; cyclin B; cyclinB; DmcycB; Dmel\CG3510; mAbF2F4

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Genomic context

Location :: 59B2-59B2

Sequence :: Chromosome: 2R; NT_033778.3 (18691026..18694490, complement)

See CycB in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

dFMRP and Caprin collaborate to control the cell cycle at the MBT by directly mediating the normal repression of maternal Cyclin B mRNA and the activation of zygotic fruhstart mRNA.
Title: dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition.
induced by myb in eye imaginal disc
Title: Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc.
CycB is required for the division of germline stem cells and their precursors.
Title: The division of Drosophila germline stem cells and their precursors requires a specific cyclin.
These data argue that changes in poly(A) tail length are not a universal mechanism governing embryonic cell cycles, and that PNG-mediated derepression of translation is an important alternative mechanism in Drosophila.
Title: The Drosophila PNG kinase complex regulates the translation of cyclin B.
We identified cyclin B as a direct transcriptional target of Fos in Drosophila melanogaster, with Fos binding to a region upstream of the cyclin B gene in vivo and cyclin B mRNA being specifically reduced under Fos loss-of-function conditions.
Title: Control of G2/M transition by Drosophila Fos.
Cyclin B associates with spindle microtubules throughout meiosis I and meiosis II, and dissociates from the meiotic spindle in anaphase II. Fzy and Cort are required for this loss of cyclin B from the meiotic spindle.
Title: The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila.
Hsp90 is required to localize CycB to the mitotic spindle.
Title: Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans.
Fzy/Cdc20 is responsible for catalyzing the first phase of cyclin B destruction that occurs on the mitotic spindle, whereas Fzr/Cdh1 is responsible for catalyzing the second phase of cyclin B destruction that occurs throughout the cell.
Title: The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and time.
interphase extension after cycle 10 is probably controlled by both cyclin B limitation and the DNA-replication checkpoint
Title: Both cyclin B levels and DNA-replication checkpoint control the early embryonic mitoses in Drosophila.
Hedgehog, Gutfeeling, and Sex-lethal function to regulate Cyclin B, providing a link between Sex-lethal and mitosis.
Title: Antizyme is a target of sex-lethal in the Drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin B.

Submit: New GeneRIF Correction See all (11)

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:63230	BioGRID:66659	Arp87C	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63230	BioGRID:61428	BubR1	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:63867	CG11486	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:63895	CG11505	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:58852	CG12708	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:65100	CG13045	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:60468	CG13138	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:62970	CG13423	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:60007	CG13996	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:68265	CG14062	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:59255	CG14207	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:59258	CG14222	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:533580	CG14425	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:65657	CG14570	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:65751	CG14641	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:66938	CG14868	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:72488	CG17450	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:57748	CG3078	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:66561	CG31211	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:65869	CG31550	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:57935	CG32772	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:76824	CG32819	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:76825	CG32820	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:64800	CG42709	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:64965	CG6945	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:62023	CG7763	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:64190	CG8368	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:60011	CG9117	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:60320	CG9465	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:59277	Cdc42	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63230	BioGRID:60354	Cks30A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:63230	BioGRID:66209	Cks85A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:63230	BioGRID:64701	CycA	BioGRID	PubMed	Affinity Capture-MS; Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63230	BioGRID:67895	CycB3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:63230	BioGRID:64049	Dhc64C	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63230	BioGRID:64877	Gl	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63230	BioGRID:58891	Myb	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63230	BioGRID:77548	Myo95E	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:58107	Nf-YC	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:66749	Rbp4	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:65211	Rbp6	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:68066	Sld5	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:60899	Su(H)	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:63374	TBPH	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:60426	Trp1	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:68905	Xbp1	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:65752	abs	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:61808	brp	BioGRID	PubMed	Two-hybrid
	NP_476797.1	cdc2	BIND	PubMed	Cyclin B interacts with Cdk1.
BioGRID:63230	BioGRID:60495	cdc2	BioGRID	PubMed	Affinity Capture-MS; Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63230	BioGRID:59999	chic	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63230	BioGRID:63117	comr	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:61303	dia	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63230	BioGRID:67755	eIF4G2	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:63243	fd59A	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:64940	gnu	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63230	BioGRID:67557	how	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:58948	mei-41	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63230	BioGRID:69972	mr	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63230	BioGRID:68000	msi	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:63711	pUf68	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:69325	plu	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63230	BioGRID:57644	png	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63230	BioGRID:61054	qua	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63230	BioGRID:62657	robl	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63230	BioGRID:58031	rux	BioGRID	PubMed	Affinity Capture-MS; Phenotypic Suppression
BioGRID:63230	BioGRID:61463	sced	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63230	BioGRID:59774	sec5	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:65184	sinah	BioGRID	PubMed	Two-hybrid
BioGRID:63230	BioGRID:58046	sqh	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63230	BioGRID:63569	zip	BioGRID	PubMed	Phenotypic Suppression

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General gene information

Homology

Homologs of the CycB gene: The CycB gene is conserved in human, chimpanzee, , dog, cow, rat, zebrafish, mosquito, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, and A.thaliana.

Pathways from BioSystems

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem (from REACTOME)
APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystemcomputationally inferred pathway (not manually curated)
APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
Cell Cycle Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle, organism-specific biosystem (from WikiPathways)
Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, organism-specific biosystem (from REACTOME)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin A/B1 associated events during G2/M transition, organism-specific biosystem (from REACTOME)
Cyclin A/B1 associated events during G2/M transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin B2 mediated events, organism-specific biosystem (from REACTOME)
Cyclin B2 mediated events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
E2F mediated regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
E2F-enabled inhibition of pre-replication complex formation, organism-specific biosystem (from REACTOME)
E2F-enabled inhibition of pre-replication complex formation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1/S Transition, organism-specific biosystem (from REACTOME)
G1/S Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2/M Checkpoints, organism-specific biosystem (from REACTOME)
G2/M Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2/M DNA damage checkpoint, organism-specific biosystem (from REACTOME)
G2/M DNA damage checkpoint, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2/M DNA replication checkpoint, organism-specific biosystem (from REACTOME)
G2/M DNA replication checkpoint, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2/M Transition, organism-specific biosystem (from REACTOME)
G2/M Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hedgehog Signaling Pathway, organism-specific biosystem (from WikiPathways)
Hedgehog Signaling Pathway, organism-specific biosystemThe Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, pre...
Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
Mitotic G2-G2/M phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Phosphorylation of the APC/C, organism-specific biosystem (from REACTOME)
Phosphorylation of the APC/C, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
Regulation of mitotic cell cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
cyclin-dependent protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
cyclin-dependent protein kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
cyclin-dependent protein kinase regulator activity	NAS Non-traceable Author Statement more info
protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G2/M transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
attachment of spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
attachment of spindle microtubules to kinetochore	TAS Traceable Author Statement more info	PubMed
cellular process	IMP Inferred from Mutant Phenotype more info	PubMed
cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
cytokinesis after mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic development via the syncytial blastoderm	TAS Traceable Author Statement more info	PubMed
mitotic anaphase B	IMP Inferred from Mutant Phenotype more info	PubMed
mitotic chromosome movement towards spindle pole	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
regulation of chromatin binding	IGI Inferred from Genetic Interaction more info	PubMed
regulation of cyclin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
response to DNA damage stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
syncytial blastoderm mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
chromosome, centromeric region	TAS Traceable Author Statement more info	PubMed
cytoplasm	TAS Traceable Author Statement more info	PubMed
nuclear cyclin-dependent protein kinase holoenzyme complex	NAS Non-traceable Author Statement more info
nucleus	IEA Inferred from Electronic Annotation more info
pole plasm	TAS Traceable Author Statement more info	PubMed
spindle	TAS Traceable Author Statement more info	PubMed
spindle midzone	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Preferred Names: CG3510 gene product from transcript CG3510-RE

Names: CG3510-PA; CG3510-PB; CG3510-PC; CG3510-PE; CycB-PA; CycB-PB; CycB-PC; CycB-PE; Cyclin-B; cyclin B; cyclin B1; cyclinB; dCyclinB

NP_726244.1

EC 2.7.1.-

NP_726245.2

EC 2.7.1.-

NP_726246.1

EC 2.7.1.-

NP_726247.1

EC 2.7.1.-

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

18691026..18694490, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166556.2 → NP_726245.2 cyclin B, isoform E [Drosophila melanogaster]

Status: REVIEWED
NM_166555.2 → NP_726244.1 cyclin B, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P20439

Related

FBpp0071822

Conserved Domains (1) summary

cd00043
Location:289 – 378
Blast Score: 177

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_166557.2 → NP_726246.1 cyclin B, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

C9QPI9

UniProtKB/Swiss-Prot

P20439

Related

FBpp0071824

Conserved Domains (1) summary

cd00043
Location:283 – 372
Blast Score: 176

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_166558.2 → NP_726247.1 cyclin B, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P20439

Related

FBpp0071825

Conserved Domains (1) summary

cd00043
Location:259 – 348
Blast Score: 176

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AE013599.4	AAM71123.2
genomic	HB439599.1	CAZ78045.1
genomic	AE013599.4	AAF46904.1
mRNA	AY102682.1	AAM27511.1
genomic	AJ006773.1	CAA07238.1
mRNA	BT100103.1	ACX70076.1
genomic	AJ006773.1	CAA07239.1
genomic	HB439533.1	CAZ78012.1
genomic	AE013599.4	AAG22197.1
genomic	AE013599.4	AAM71124.1
genomic	HB439535.1	CAZ78013.1
genomic	AJ006773.1	CAA07240.1