These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_008916.1 RefSeqGene
- Range
- 4613..37971
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_288
mRNA and Protein(s)
-
NM_000238.3 → NP_000229.1 potassium voltage-gated channel subfamily H member 2 isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (a).
- Source sequence(s)
-
AF363636, BM674996, DQ525913, U04270
- Consensus CDS
-
CCDS5910.1
- UniProtKB/Swiss-Prot
-
Q12809
- UniProtKB/TrEMBL
-
Q15BH2
- Related
- ENSP00000262186, OTTHUMP00000212821, ENST00000262186, OTTHUMT00000350741
- Conserved Domains (5) summary
-
- cd00038
Location:742 – 853
Blast Score: 212
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- cd00130
Location:41 – 132
Blast Score: 112
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- PLN03192
Location:410 – 847
Blast Score: 315
- PLN03192; Voltage-dependent potassium channel; Provisional
- pfam13426
Location:29 – 130
Blast Score: 187
- PAS_9; PAS domain
- cl11596
Location:611 – 660
Blast Score: 136
- Ion_trans_2; Ion channel
-
NM_001204798.1 → NP_001191727.1 potassium voltage-gated channel subfamily H member 2 isoform d
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and 5' and 3' coding regions compared to variant 1, resulting in a shorter isoform (d) with different N- and C-termini compared to isoform a.
- Source sequence(s)
-
AJ609614, BC001914, BG683210, BQ478289
- UniProtKB/Swiss-Prot
-
Q12809
- UniProtKB/TrEMBL
-
Q708S9
- Conserved Domains (3) summary
-
- cd00038
Location:402 – 462
Blast Score: 121
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- PLN03192
Location:70 – 462
Blast Score: 282
- PLN03192; Voltage-dependent potassium channel; Provisional
- cl11596
Location:271 – 320
Blast Score: 124
- Ion_trans_2; Ion channel
-
NM_172056.2 → NP_742053.1 potassium voltage-gated channel subfamily H member 2 isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (2), also known as HERG-USO, differs in the 3' UTR and 3' coding region compared to variant 1, resulting in a shorter isoform (b) with a different C-terminus compared to isoform a.
- Source sequence(s)
-
AB044806, BC001914, BQ478289, DQ525913
- Consensus CDS
-
CCDS47747.1
- UniProtKB/TrEMBL
-
G5E9I0
- UniProtKB/Swiss-Prot
-
Q12809
- UniProtKB/TrEMBL
-
Q15BH2
- Related
- ENSP00000387657, ENST00000430723
- Conserved Domains (5) summary
-
- cd00038
Location:742 – 802
Blast Score: 122
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- cd00130
Location:41 – 132
Blast Score: 112
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- PLN03192
Location:410 – 802
Blast Score: 283
- PLN03192; Voltage-dependent potassium channel; Provisional
- pfam13426
Location:29 – 130
Blast Score: 187
- PAS_9; PAS domain
- cl11596
Location:611 – 660
Blast Score: 132
- Ion_trans_2; Ion channel
-
NM_172057.2 → NP_742054.1 potassium voltage-gated channel subfamily H member 2 isoform c
Status: REVIEWED
- Description
- Transcript Variant: This variant (3), also known as HERG1b, differs in the 5' UTR and 5' coding region compared to variant 1, resulting in a shorter isoform (c) with a different N-terminus compared to isoform a.
- Source sequence(s)
-
AJ512214, BG683210, BM674996, U04270
- Consensus CDS
-
CCDS5911.1
- UniProtKB/Swiss-Prot
-
Q12809
- Related
- ENSP00000328531, OTTHUMP00000212824, ENST00000330883, OTTHUMT00000350744
- Conserved Domains (3) summary
-
- cd00038
Location:402 – 513
Blast Score: 210
- CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
- PLN03192
Location:70 – 507
Blast Score: 314
- PLN03192; Voltage-dependent potassium channel; Provisional
- cl11596
Location:271 – 320
Blast Score: 133
- Ion_trans_2; Ion channel
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000007.13 Reference GRCh37.p5 Primary Assembly
- Range
- 150642044..150675402, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000139.1 Alternate HuRef
- Range
- 144454320..144487268, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate CRA_TCAGchr7v2
Genomic
-
AC_000068.1 Alternate CRA_TCAGchr7v2
- Range
- 149971333..150004698, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)