Mes4 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: Mes4provided by Flybase
Primary source: FLYBASE:FBgn0034726
Locus tag: Dmel_CG11301
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 11301; BcDNA:GM21739; CG11301; Dmel\CG11301; NF-Yc

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Genomic context

Location :: 58D8-58D8

Sequence :: Chromosome: 2R; NT_033778.3 (18299312..18300087)

See Mes4 in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identification of the Drosophila Mes4 gene as a novel target of the transcription factor DREF was confirmed.
Title: Identification of the Drosophila Mes4 gene as a novel target of the transcription factor DREF.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:63176	BioGRID:69379	And	BioGRID	PubMed	Two-hybrid
BioGRID:63176	BioGRID:61108	Atac2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:63176	BioGRID:67658	CG17244	BioGRID	PubMed	Two-hybrid
BioGRID:63176	BioGRID:67611	CG5315	BioGRID	PubMed	Two-hybrid
BioGRID:63176	BioGRID:66608	MBD-R2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:63176	BioGRID:67937	Mocs2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:63176	BioGRID:60894	NC2beta	BioGRID	PubMed	Two-hybrid
BioGRID:63176	BioGRID:61237	Nf-YB	BioGRID	PubMed	Two-hybrid
BioGRID:63176	BioGRID:64780	Pcaf	BioGRID	PubMed	Affinity Capture-MS
BioGRID:63176	BioGRID:62311	Rcd1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:63176	BioGRID:63063	Sgf29	BioGRID	PubMed	Affinity Capture-MS
BioGRID:63176	BioGRID:59107	dik	BioGRID	PubMed	Affinity Capture-MS

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General gene information

Pathways from BioSystems

Base excision repair, organism-specific biosystem (from KEGG)
Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
Base excision repair, conserved biosystem (from KEGG)
Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
DNA polymerase epsilon complex, organism-specific biosystem (from KEGG)
DNA polymerase epsilon complex, organism-specific biosystemStructural complex; Genetic information processing; DNA polymerase
DNA replication, organism-specific biosystem (from KEGG)
DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
DNA replication, conserved biosystem (from KEGG)
DNA replication, conserved biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Nucleotide excision repair, organism-specific biosystem (from KEGG)
Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
Nucleotide excision repair, conserved biosystem (from KEGG)
Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
Purine metabolism, organism-specific biosystem (from KEGG)
Purine metabolism, organism-specific biosystem
Purine metabolism
Purine metabolism, conserved biosystem (from KEGG)
Purine metabolism, conserved biosystem
Purine metabolism
Pyrimidine metabolism, organism-specific biosystem (from KEGG)
Pyrimidine metabolism, organism-specific biosystem
Pyrimidine metabolism
Pyrimidine metabolism, conserved biosystem (from KEGG)
Pyrimidine metabolism, conserved biosystem
Pyrimidine metabolism

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
DNA-directed DNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA replication	IC Inferred by Curator more info
response to DNA damage stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
epsilon DNA polymerase complex	IC Inferred by Curator more info
intracellular	IEA Inferred from Electronic Annotation more info

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General protein information

Preferred Names: CG11301 gene product from transcript CG11301-RB

Names: CG11301-PA; CG11301-PB; Mes4; Mes4-PA; Mes4-PB; NF-YC-like

NP_001163253.1

EC 2.7.7.7

NP_611669.1

EC 2.7.7.7

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

18299312..18300087

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169782.1 → NP_001163253.1 Mes4, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9W256

Related

FBpp0290461, FBtr0301243

Conserved Domains (1) summary

cl00074
Location:78 – 140
Blast Score: 155

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
NM_137825.3 → NP_611669.1 Mes4, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9W256

Related

FBpp0071738, FBtr0071827

Conserved Domains (1) summary

cl00074
Location:78 – 140
Blast Score: 155

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...