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KCNG1 potassium voltage-gated channel modifier subfamily G member 1 [ Homo sapiens (human) ]

Gene ID: 3755, updated on 26-May-2016
Official Symbol
KCNG1provided by HGNC
Official Full Name
potassium voltage-gated channel modifier subfamily G member 1provided by HGNC
Primary source
HGNC:HGNC:6248
See related
Ensembl:ENSG00000026559 HPRD:04809; MIM:603788; Vega:OTTHUMG00000032745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K13; kH2; KCNG; KV6.1
Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]
Orthologs
Location:
20q13
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (51003656..51023176, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49620193..49639675, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ADNP antisense RNA 1 Neighboring gene dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene uncharacterized LOC105372661 Neighboring gene uncharacterized LOC105372662 Neighboring gene ribosomal protein SA pseudogene 1

NHGRI GWAS Catalog

Description
Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of KCNG1 by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed
Knockdown of potassium voltage-gated channel, subfamily G, member 1 (KCNG1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Voltage gated Potassium channels, organism-specific biosystem (from REACTOME)
    Voltage gated Potassium channels, organism-specific biosystemVoltage-gated K+ channels (Kv) determine the excitability of heart, brain and skeletal muscle cells. Kv form octameric channel with alpha subunits that forms the pore of the channel and associated be...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC12878

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium channel activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium ion transport NAS
Non-traceable Author Statement
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
colocalizes_with voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
potassium voltage-gated channel subfamily G member 1
Names
potassium channel KH2
potassium channel Kv6.1
potassium channel, voltage gated modifier subfamily G, member 1
potassium voltage-gated channel, subfamily G, member 1
voltage-gated potassium channel subunit Kv6.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002237.3NP_002228.2  potassium voltage-gated channel subfamily G member 1

    See identical proteins and their annotated locations for NP_002228.2

    Status: REVIEWED

    Source sequence(s)
    AF033383, BC046629, BG029104, CN301212, CN480356, DA580190, DA684016
    Consensus CDS
    CCDS13436.1
    UniProtKB/Swiss-Prot
    Q9UIX4
    UniProtKB/TrEMBL
    Q86Y85
    Related
    ENSP00000360626, OTTHUMP00000043416, ENST00000371571, OTTHUMT00000079726
    Conserved Domains (3) summary
    pfam00520
    Location:270456
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383460
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    51003656..51023176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528804.1XP_011527106.1  

    See identical proteins and their annotated locations for XP_011527106.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (3) summary
    pfam00520
    Location:270456
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383460
    Ion_trans_2; Ion channel
  2. XM_011528800.1XP_011527102.1  

    See identical proteins and their annotated locations for XP_011527102.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (3) summary
    pfam00520
    Location:270456
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383460
    Ion_trans_2; Ion channel
  3. XM_011528802.1XP_011527104.1  

    See identical proteins and their annotated locations for XP_011527104.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (3) summary
    pfam00520
    Location:270456
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383460
    Ion_trans_2; Ion channel
  4. XM_011528801.1XP_011527103.1  

    See identical proteins and their annotated locations for XP_011527103.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (3) summary
    pfam00520
    Location:270456
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383460
    Ion_trans_2; Ion channel
  5. XM_011528806.1XP_011527108.1  

    See identical proteins and their annotated locations for XP_011527108.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (3) summary
    pfam00520
    Location:270456
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383460
    Ion_trans_2; Ion channel
  6. XM_006723785.2XP_006723848.1  

    See identical proteins and their annotated locations for XP_006723848.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (3) summary
    pfam00520
    Location:270456
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383460
    Ion_trans_2; Ion channel
  7. XM_011528803.1XP_011527105.1  

    See identical proteins and their annotated locations for XP_011527105.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (3) summary
    pfam00520
    Location:270456
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383460
    Ion_trans_2; Ion channel
  8. XM_011528805.1XP_011527107.1  

    See identical proteins and their annotated locations for XP_011527107.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (3) summary
    pfam00520
    Location:270456
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
    pfam07885
    Location:383460
    Ion_trans_2; Ion channel

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    49525802..49545284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172318.2: Suppressed sequence

    Description
    NM_172318.2: This RefSeq was temporarily suppressed because its source, BC006367.1, was from a cancerous cell line. The remaining transcript data that support this splice variant are of incomplete length.