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MAST4 microtubule associated serine/threonine kinase family member 4 [ Homo sapiens (human) ]

Gene ID: 375449, updated on 7-Dec-2014
Official Symbol
MAST4provided by HGNC
Official Full Name
microtubule associated serine/threonine kinase family member 4provided by HGNC
Primary source
HGNC:HGNC:19037
See related
Ensembl:ENSG00000069020; HPRD:14195; Vega:OTTHUMG00000152471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
See MAST4 in Epigenomics, MapViewer
Location:
5q12.3
Exon count:
37
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (66596348..67169598)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (65892176..66465426)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928769 Neighboring gene peptidylprolyl isomerase A (cyclophilin A) pseudogene Neighboring gene uncharacterized LOC101928794 Neighboring gene CD180 molecule Neighboring gene uncharacterized LOC101928819

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of carotid atherosclerosis in HIV-infected men.
NHGRI GWA Catalog
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ16540, FLJ33039, KIAA0303, DKFZp686N1467, DKFZp686E18148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
microtubule-associated serine/threonine-protein kinase 4
Names
microtubule-associated serine/threonine-protein kinase 4
NP_001158136.1
NP_055998.1
NP_942123.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034036.1 

    Range
    5001..578248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164664.1NP_001158136.1  microtubule-associated serine/threonine-protein kinase 4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC008872, AC008920, AC016634, AC044799, AC092373
    Consensus CDS
    CCDS54861.1
    UniProtKB/TrEMBL
    J3QT34
    Related
    ENSP00000385727, OTTHUMP00000201718, ENST00000403625, OTTHUMT00000326324
    Conserved Domains (4) summary
    cd05609
    Location:568872
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:258532
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:570843
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11461224
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001290226.1NP_001277155.1  microtubule-associated serine/threonine-protein kinase 4 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter, differs in the 5' UTR, uses a downstream start codon, and has an alternate in-frame exon compared to variant 3. The encoded protein (isoform d) has a shorter and distinct N-terminus compared to isoform c.
    Source sequence(s)
    AB002301, AC044799, AK299538, DA794310
    UniProtKB/TrEMBL
    B4DS23
    UniProtKB/Swiss-Prot
    O15021
    Conserved Domains (4) summary
    cd05609
    Location:362666
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:49326
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:364637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9401018
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001290227.1NP_001277156.1  microtubule-associated serine/threonine-protein kinase 4 isoform e

    See proteins identical to NP_001277156.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter, differs in the 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon compared to variant 3. The encoded protein (isoform e) has a shorter and distinct N-terminus compared to isoform c.
    Source sequence(s)
    AC008872, AC044799, AK296707
    UniProtKB/TrEMBL
    B4DKT8
    Conserved Domains (4) summary
    cd05609
    Location:374678
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64338
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:376649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:885963
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. NM_001290228.1NP_001277157.1  microtubule-associated serine/threonine-protein kinase 4 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses a distinct 3' coding region and 3' UTR compared to variant 3. The encoded protein (isoform f) has a shorter and distinct C-terminus compared to isoform c.
    Source sequence(s)
    AC008872, AC092373, AY439222, BC033215, CB044105
    UniProtKB/TrEMBL
    E7EX28
    UniProtKB/Swiss-Prot
    O15021
    UniProtKB/TrEMBL
    Q6T2V4
  5. NM_001297651.1NP_001284580.1  microtubule-associated serine/threonine-protein kinase 4 isoform g

    See proteins identical to NP_001284580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate 5' exon, compared to variant 3. The encoded isoform (g) is shorter and has a distinct N-terminus, compared to isoform c.
    Source sequence(s)
    AC044799, AK057601, AK299706, AY830839, BF515864
    Consensus CDS
    CCDS75254.1
    UniProtKB/TrEMBL
    B4DSE5
    UniProtKB/Swiss-Prot
    O15021
    Conserved Domains (4) summary
    cd05609
    Location:374678
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64338
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:376649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9521030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. NM_015183.2NP_055998.1  microtubule-associated serine/threonine-protein kinase 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and includes an alternate in-frame exon in the 5' coding region, compared to variant 3. The resulting isoform (a) has a shorter N-terminus and includes an additional segment near the N-terminus, compared to isoform c.
    Source sequence(s)
    AC044799, AY830839
    Consensus CDS
    CCDS47225.1
    UniProtKB/Swiss-Prot
    O15021
    Conserved Domains (4) summary
    cd05609
    Location:379683
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:69343
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:381654
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9571035
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. NM_198828.2NP_942123.1  microtubule-associated serine/threonine-protein kinase 4 isoform b

    See proteins identical to NP_942123.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a distinct 3' coding region and 3' UTR, compared to variant 3. The resulting isoform (b) has a substantially shorter and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    BC033215, BM967134
    Consensus CDS
    CCDS47224.1
    UniProtKB/Swiss-Prot
    O15021
    Related
    ENSP00000385088, OTTHUMP00000201724, ENST00000406374, OTTHUMT00000326333

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    66596348..67169598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714602.1XP_006714665.1  

    Conserved Domains (4) summary
    cd05609
    Location:596900
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:283560
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:598871
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11741252
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_005248498.1XP_005248555.1  

    Conserved Domains (4) summary
    cd05609
    Location:571875
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:258535
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:573846
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11491227
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_006714607.1XP_006714670.1  

    Conserved Domains (4) summary
    cd05609
    Location:370674
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:57334
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:372645
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9481026
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_006714612.1XP_006714675.1  

    Conserved Domains (4) summary
    cd05609
    Location:220524
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:1184
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:222495
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:798876
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_006714608.1XP_006714671.1  

    Conserved Domains (4) summary
    cd05609
    Location:362666
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:49326
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:364637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9401018
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_006714604.1XP_006714667.1  

    See proteins identical to XP_006714667.1

    Conserved Domains (4) summary
    cd05609
    Location:377681
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64341
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:379652
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9551033
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. XM_006714606.1XP_006714669.1  

    See proteins identical to XP_006714669.1

    UniProtKB/Swiss-Prot
    O15021
    Conserved Domains (4) summary
    cd05609
    Location:374678
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64338
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:376649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9521030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  8. XM_006714611.1XP_006714674.1  

    Conserved Domains (4) summary
    cd05609
    Location:374678
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64338
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:376649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:885963
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  9. XM_006714603.1XP_006714666.1  

    See proteins identical to XP_006714666.1

    Conserved Domains (4) summary
    cd05609
    Location:377681
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64341
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:379652
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9551033
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  10. XM_006714605.1XP_006714668.1  

    Conserved Domains (4) summary
    cd05609
    Location:374678
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64338
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:376649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9521030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  11. XM_006714610.1XP_006714673.1  

    See proteins identical to XP_006714673.1

    Conserved Domains (4) summary
    cd05609
    Location:374678
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64338
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:376649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:885963
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  12. XM_006714609.1XP_006714672.1  

    Conserved Domains (4) summary
    cd05609
    Location:359663
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:46323
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:361634
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9371015
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    65892076..66465814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    62849136..63424533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)