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MAST4 microtubule associated serine/threonine kinase family member 4 [ Homo sapiens (human) ]

Gene ID: 375449, updated on 8-May-2016
Official Symbol
MAST4provided by HGNC
Official Full Name
microtubule associated serine/threonine kinase family member 4provided by HGNC
Primary source
HGNC:HGNC:19037
See related
Ensembl:ENSG00000069020 HPRD:14195; Vega:OTTHUMG00000152471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Orthologs
Location:
5q12.3
Exon count:
42
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (66596348..67169598)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (65892176..66465426)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC401191 Neighboring gene uncharacterized LOC105379002 Neighboring gene uncharacterized LOC101928769 Neighboring gene peptidylprolyl isomerase A (cyclophilin A) pseudogene Neighboring gene uncharacterized LOC101928794 Neighboring gene CD180 molecule Neighboring gene uncharacterized LOC101928819

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of carotid atherosclerosis in HIV-infected men.
NHGRI GWA Catalog
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ16540, FLJ33039, KIAA0303, DKFZp686N1467, DKFZp686E18148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
NOT cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
microtubule-associated serine/threonine-protein kinase 4
NP_001158136.1
NP_001277155.1
NP_001277156.1
NP_001277157.1
NP_001284580.1
NP_055998.1
NP_942123.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034036.1 RefSeqGene

    Range
    5001..578248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164664.1NP_001158136.1  microtubule-associated serine/threonine-protein kinase 4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC008872, AC008920, AC016634, AC044799, AC092373
    Consensus CDS
    CCDS54861.1
    UniProtKB/TrEMBL
    J3QT34
    Related
    ENSP00000385727, OTTHUMP00000201718, ENST00000403625, OTTHUMT00000326324
    Conserved Domains (4) summary
    pfam08926
    Location:258532
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:570843
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11461224
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:569848
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  2. NM_001290226.1NP_001277155.1  microtubule-associated serine/threonine-protein kinase 4 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter, differs in the 5' UTR, uses a downstream start codon, and has an alternate in-frame exon compared to variant 3. The encoded protein (isoform d) has a shorter and distinct N-terminus compared to isoform c.
    Source sequence(s)
    AB002301, AC044799, AK299538, DA794310
    UniProtKB/Swiss-Prot
    O15021
    UniProtKB/TrEMBL
    B4DS23
    Related
    ENSP00000384099, OTTHUMP00000201720, ENST00000405643, OTTHUMT00000326326
    Conserved Domains (4) summary
    pfam08926
    Location:49326
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:364637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9401018
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:363642
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  3. NM_001290227.1NP_001277156.1  microtubule-associated serine/threonine-protein kinase 4 isoform e

    See identical proteins and their annotated locations for NP_001277156.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter, differs in the 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon compared to variant 3. The encoded protein (isoform e) has a shorter and distinct N-terminus compared to isoform c.
    Source sequence(s)
    AC008872, AC044799, AK296707
    UniProtKB/TrEMBL
    B4DKT8
    Conserved Domains (4) summary
    pfam08926
    Location:64338
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:376649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:885963
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  4. NM_001290228.1NP_001277157.1  microtubule-associated serine/threonine-protein kinase 4 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses a distinct 3' coding region and 3' UTR compared to variant 3. The encoded protein (isoform f) has a shorter and distinct C-terminus compared to isoform c.
    Source sequence(s)
    AC008872, AC092373, AY439222, BC033215, CB044105
    Consensus CDS
    CCDS78015.1
    UniProtKB/Swiss-Prot
    O15021
    UniProtKB/TrEMBL
    E7EX28, Q6T2V4
    Related
    ENSP00000384547, OTTHUMP00000201725, ENST00000406039, OTTHUMT00000326334
  5. NM_001297651.1NP_001284580.1  microtubule-associated serine/threonine-protein kinase 4 isoform g

    See identical proteins and their annotated locations for NP_001284580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate 5' exon, compared to variant 3. The encoded isoform (g) is shorter and has a distinct N-terminus, compared to isoform c.
    Source sequence(s)
    AC044799, AK057601, AK299706, AY830839, BF515864
    Consensus CDS
    CCDS75254.1
    UniProtKB/Swiss-Prot
    O15021
    UniProtKB/TrEMBL
    B4DSE5
    Related
    ENSP00000261569, OTTHUMP00000201722, ENST00000261569, OTTHUMT00000326330
    Conserved Domains (4) summary
    pfam08926
    Location:64338
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:376649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9521030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  6. NM_015183.2NP_055998.1  microtubule-associated serine/threonine-protein kinase 4 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and includes an alternate in-frame exon in the 5' coding region, compared to variant 3. The resulting isoform (a) has a shorter N-terminus and includes an additional segment near the N-terminus, compared to isoform c.
    Source sequence(s)
    AC044799, AY830839
    Consensus CDS
    CCDS47225.1
    UniProtKB/Swiss-Prot
    O15021
    Related
    ENSP00000384313, OTTHUMP00000201719, ENST00000403666, OTTHUMT00000326325
    Conserved Domains (4) summary
    pfam08926
    Location:69343
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:381654
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9571035
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:380659
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  7. NM_198828.2NP_942123.1  microtubule-associated serine/threonine-protein kinase 4 isoform b

    See identical proteins and their annotated locations for NP_942123.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a distinct 3' coding region and 3' UTR, compared to variant 3. The resulting isoform (b) has a substantially shorter and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    BC033215, BM967134
    Consensus CDS
    CCDS47224.1
    UniProtKB/Swiss-Prot
    O15021
    Related
    ENSP00000385088, OTTHUMP00000201724, ENST00000406374, OTTHUMT00000326333

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    66596348..67169598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543383.1XP_011541685.1  

    Conserved Domains (4) summary
    pfam08926
    Location:270544
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:582855
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11581236
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:581860
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  2. XM_011543381.1XP_011541683.1  

    Conserved Domains (4) summary
    pfam08926
    Location:357631
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:669942
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:12451323
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:668947
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  3. XM_011543382.1XP_011541684.1  

    Conserved Domains (4) summary
    pfam08926
    Location:295569
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:607880
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11831261
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:606885
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  4. XM_011543385.1XP_011541687.1  

    Conserved Domains (4) summary
    pfam08926
    Location:49323
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:361634
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9371015
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:360639
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  5. XM_006714606.2XP_006714669.1  

    See identical proteins and their annotated locations for XP_006714669.1

    UniProtKB/Swiss-Prot
    O15021
    Conserved Domains (4) summary
    pfam08926
    Location:64338
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:376649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9521030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  6. XM_006714610.1XP_006714673.1  

    See identical proteins and their annotated locations for XP_006714673.1

    Conserved Domains (4) summary
    pfam08926
    Location:64338
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:376649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:885963
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  7. XM_011543386.1XP_011541688.1  

    Conserved Domains (4) summary
    pfam08926
    Location:46320
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:358631
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9341012
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:357636
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  8. XM_011543384.1XP_011541686.1  

    Conserved Domains (4) summary
    pfam08926
    Location:58332
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:370643
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9461024
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:369648
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    65892076..66465814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)