Fmr1 [Drosophila melanogaster] - Gene

Help top of page

Summary

Official Symbol: Fmr1provided by Flybase
Primary source: FLYBASE:FBgn0028734
Locus tag: Dmel_CG6203
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AT24755; BcDNA:GM08679; cg6203; CG6203; dfmr; dFMR; dfmr1; dFmr1; dFMR1; dFmrp; dFMRP; dfxr; dFXR; dfxr1; dFXR1; dFXRP; Dmel\CG6203; dmfr1; EP(3)3517; fmr; FMR; fmr1; FMR1; Fmrp; FMRp; FMRP; FXR

Help top of page

Genomic context

Location :: 85F10-85F12

Sequence :: Chromosome: 3R; NT_033777.2 (5927142..5935843, complement)

See Fmr1 in Epigenomics, MapViewer

Chromosome 3R - NT_033777.2 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fmr1 encodes two functional isoforms with respect to expression and activity throughout neuronal development.
Title: A non-canonical start codon in the Drosophila fragile X gene yields two functional isoforms.
The results of this study suggested that dFMR1 with the RNA-editing pathway and suggest that proper NMJ synaptic architecture requires modulation of dADAR activity by dFMR1.
Title: Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein.
requirement of dFMRP for the retention of transitory peptidergic neurons shows evident circuit specificity
Title: Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons.
Changes in magnitude and fidelity of calcium signals in the absence of FMRP may contribute to defects in neuronal structure and function, leading to hallmark learning and memory dysfunction of fragile X syndrome.
Title: The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons.
study demonstrates that the gene Fmr1 plays an important role in sleep-dependent synaptic renormalization
Title: Sleep and synaptic homeostasis: structural evidence in Drosophila.
These results demonstrate that dFMRP plays a crucial role in controlling MT formation and mitochondrial transport.
Title: Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria.
Data show that in the early embryo dFMRP associates specifically with Caprin, and with eIF4G, a key regulator of translational initiation.
Title: dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition.
FMR1 protein expression in blood smear for Fragile X syndrome diagnosis.
Title: FMR1 protein expression in blood smears for fragile X syndrome diagnosis in a Mexican population sample.
FMRP is required during brain development to control the exit from quiescence and proliferative capacity of neuroblasts as well as neuron production.
Title: Fragile X protein controls neural stem cell proliferation in the Drosophila brain.
These results indicate that FMR1 gene function is evolutionarily conserved in neural mechanisms and cannot be compensated by either FXR1 or FXR2, but that all three proteins can substitute for each other in non-neuronal requirements.
Title: Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P.

Submit: New GeneRIF Correction See all (43)

Help top of page

Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:63147	BioGRID:60738	A16	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:65002	AGO2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:63147	BioGRID:57550	CG12470	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:65741	CG12768	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:63701	CG2199	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:64758	CG4328	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:62101	CG8854	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:60514	CHIP	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:67642	Dcr-1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:63147	BioGRID:61171	Lim3	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:67225	Nup43	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:65943	Rm62	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:63147	BioGRID:62897	RpL11	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:63147	BioGRID:78249	RpL5	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:63147	BioGRID:60577	Stam	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:60980	cact	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:59516	dock	BioGRID	PubMed	Two-hybrid
BioGRID:63147	BioGRID:625175	futsch	BioGRID	PubMed	Phenotypic Suppression; Protein-RNA
BioGRID:63147	BioGRID:69326	pnr	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63147	BioGRID:65064	th	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63147	BioGRID:61139	tup	BioGRID	PubMed	Two-hybrid

Help top of page

General gene information

Homology

Homologs of the Fmr1 gene: The Fmr1 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, and zebrafish.

Pathways from BioSystems

RNA transport, organism-specific biosystem (from KEGG)
RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
RNA transport, conserved biosystem (from KEGG)
RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
RNA binding	IDA Inferred from Direct Assay more info	PubMed
mRNA binding	IDA Inferred from Direct Assay more info	PubMed
mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
mRNA binding	NAS Non-traceable Author Statement more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein self-association	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
brain development	IMP Inferred from Mutant Phenotype more info	PubMed
cellularization	IDA Inferred from Direct Assay more info	PubMed
cellularization	IGI Inferred from Genetic Interaction more info
NOT chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
circadian rhythm	TAS Traceable Author Statement more info	PubMed
circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
germ cell development	IGI Inferred from Genetic Interaction more info	PubMed
germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
germ-line cyst formation	IGI Inferred from Genetic Interaction more info	PubMed
germ-line cyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
heterochromatin assembly	IMP Inferred from Mutant Phenotype more info	PubMed
larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
locomotion	TAS Traceable Author Statement more info	PubMed
locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
male courtship behavior	IMP Inferred from Mutant Phenotype more info
male courtship behavior	TAS Traceable Author Statement more info	PubMed
mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of translation	IEP Inferred from Expression Pattern more info	PubMed
neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
oocyte dorsal/ventral axis specification	IGI Inferred from Genetic Interaction more info	PubMed
NOT phototaxis	IMP Inferred from Mutant Phenotype more info	PubMed
pole cell formation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of mitotic cell cycle, embryonic	IGI Inferred from Genetic Interaction more info
regulation of synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of synaptic growth at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of translation	NAS Non-traceable Author Statement more info	PubMed
short-term memory	IMP Inferred from Mutant Phenotype more info
sperm axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
synapse assembly	NAS Non-traceable Author Statement more info	PubMed
NOT synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
RNA-induced silencing complex	IPI Inferred from Physical Interaction more info	PubMed
RNA-induced silencing complex	TAS Traceable Author Statement more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
lipid particle	IDA Inferred from Direct Assay more info	PubMed
micro-ribonucleoprotein complex	TAS Traceable Author Statement more info	PubMed

Help top of page

General protein information

Preferred Names: CG6203 gene product from transcript CG6203-RC

Names: CG6203-PA; CG6203-PB; CG6203-PC; CG6203-PD; CG6203-PE; CG6203-PF; CG6203-PG; Fmr1; Fmr1-PA; Fmr1-PB; Fmr1-PC; Fmr1-PD; Fmr1-PE; Fmr1-PF; Fmr1-PG; Fragile-X mental retardation protein; Fragile-X-related; dFmr1; drosophila fragile X mental retardation protein; fragile X; fragile X mental retardation 1; fragile X mental retardation gene; fragile X mental retardation protein; fragile X protein; fragile X related protein; fragile X-related; fragile x related; fragile-X

NP_001247017.1

non-AUG (CUG) translation initiation

Help top of page

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.2

Range

5927142..5935843, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169324.2 → NP_731443.1 Fmr1, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NFU0

Related

FBpp0081676, FBtr0082198

Conserved Domains (3) summary

cd00105
Location:289 – 357
Blast Score: 113

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cl00098
Location:223 – 282
Blast Score: 96

KH-II; KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional ...

cl15261
Location:59 – 115
Blast Score: 95

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
NM_001260088.1 → NP_001247017.1 Fmr1, isoform G [Drosophila melanogaster]

Status: REVIEWED
NM_169326.2 → NP_731445.1 Fmr1, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NFU0

Related

FBpp0081678, FBtr0082200

Conserved Domains (3) summary

cd00105
Location:251 – 319
Blast Score: 112

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cl00098
Location:185 – 244
Blast Score: 95

KH-II; KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional ...

cl15261
Location:21 – 77
Blast Score: 96

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
NM_001170109.1 → NP_001163580.1 Fmr1, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

B3LF78

Related

FBpp0290600, FBtr0301386

Conserved Domains (3) summary

cd00105
Location:251 – 322
Blast Score: 105

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cl00098
Location:185 – 244
Blast Score: 95

KH-II; KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional ...

cl15261
Location:21 – 77
Blast Score: 96

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
NM_137801.4 → NP_611645.1 Fmr1, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NFU0

Related

FBpp0081675

Conserved Domains (3) summary

cd00105
Location:289 – 360
Blast Score: 106

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cl00098
Location:223 – 282
Blast Score: 96

KH-II; KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional ...

cl15261
Location:59 – 115
Blast Score: 95

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
NM_169325.3 → NP_731444.1 Fmr1, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NFU0

Related

FBpp0081677

Conserved Domains (3) summary

cd00105
Location:289 – 357
Blast Score: 113

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cl00098
Location:223 – 282
Blast Score: 96

KH-II; KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional ...

cl15261
Location:59 – 115
Blast Score: 95

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
NM_169327.2 → NP_731446.1 Fmr1, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NFU0

Related

FBpp0081674

Conserved Domains (4) summary

cd00105
Location:289 – 350
Blast Score: 111

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam12235
Location:359 – 400
Blast Score: 79

FXR1P_C; Fragile X-related 1 protein C terminal

cl00098
Location:223 – 282
Blast Score: 95

KH-II; KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional ...

cl15261
Location:59 – 115
Blast Score: 94

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
mRNA	AF205596.1	AAF14639.1
genomic	AE014297.2	AAN13451.1
mRNA	AJ422083.1	CAD19444.1
genomic	AE014297.2	AAN13452.1
mRNA	BT031124.1	ABX00746.1
genomic	AF205597.1	AAF14640.1
genomic	AE014297.2	AFH06335.1
genomic	AE014297.2	AAN13453.1
genomic	AE014297.2	ACZ94877.1
mRNA	BT033066.1	ACE82589.1
mRNA	AJ271221.1	CAB66340.1
genomic	AE014297.2	AAF54493.2
genomic	AE014297.2	AAN13454.1
mRNA	AJ413217.1	CAC88757.2