Egfr Epidermal growth factor receptor [ Drosophila melanogaster ]

Gene ID: 37455, updated on 19-May-2012

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Summary

Official Symbol: Egfrprovided by Flybase
Official Full Name: Epidermal growth factor receptorprovided by Flybase
Primary source: FLYBASE:FBgn0003731
Locus tag: Dmel_CG10079
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: C-erb; c-erbB; CG10079; D-Egf; d-egf-r; D-EGFR; dEgfr; dEGFR; Degfr; DEGFR; dEGFR1; der; Der; DER; DER flb; DER/EGFR; DER/faint little ball; DER/top; DER/torpedo; DER1; Dmel\CG10079; DmHD-33; EFG-R; Egf; Egf-r; EGF-R; egfr; EgfR; EGFr; EGFR; EK2-6; El; Elp; Elp-1; Elp-B1; Elp-B1RB1; flb; HD-33; l(2)05351; l(2)09261; l(2)57DEFa; l(2)57Ea; l(2)57EFa; mor1; top; TOP; top/DER; top/flb; Torpedo/DER; torpedo/egfr; torpedo/Egfr; Torpedo/Egfr

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Genomic context

Location :: 57E9-57F1

Sequence :: Chromosome: 2R; NT_033778.3 (17410510..17446932)

See Egfr in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Holn1 acts downstream of EGFR and ERK signaling in the Grh/Fos mediated wound closure pathway.
Title: Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila.
Findings provide strong evidence that Msk signals non-autonomously through the Vein-Egfr signaling pathway for late tendon cell late differentiation and/or maintenance.
Title: Moleskin is essential for the formation of the myotendinous junction in Drosophila.
Data show that the differentiation delay phenotype is caused by decreased levels of different components of the EGFR signaling pathway in the absence of rbf and rno.
Title: RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye.
Egfr signaling is required for specification of alternative neuroblast identities.
Title: Serial specification of diverse neuroblast identities from a neurogenic placode by Notch and Egfr signaling.
Drk plays a negative role in EGFR signaling by enhancing receptor endocytosis through cooperating with the RING domain of D-Cbl.
Title: D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis.
Data suggest that ISC self-renewal is cooperatively controlled by EGFR, Wg and JAK/STAT signaling pathway activities.
Title: EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells.
EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila
Title: EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila.
EGFR pathway coordinates stem cell proliferation and gut remodeling following infection.
Title: Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection.
Data show that expression of a dominant negative form of rab11 induces a loss of the polarization of RTK activity, which correlates with a severe migration phenotype.
Title: Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration.
Bap170 participates instead in the negative regulation of EGFR signaling
Title: Bap170, a subunit of the Drosophila PBAP chromatin remodeling complex, negatively regulates the EGFR signaling.

Submit: New GeneRIF Correction See all (71)

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:63083	BioGRID:59052	B-H1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:67045	CSN5	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:68974	CanB	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:67310	Dl	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:62224	Dp	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:58322	Dsor1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:67516	E2f	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:64545	Gap1	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:67421	H	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:61885	Jra	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:77452	Krn	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:62511	Lis-1	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:57823	N	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:58251	Nrg	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:58962	Pp2B-14D	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:59185	Pvf1	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:60256	Pvr	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:66301	Ras85D	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:59534	S	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:62337	SelD	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:68802	Shc	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:61430	Src42A	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:67407	Stat92E	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:64448	Tequila	BioGRID	PubMed	Two-hybrid
BioGRID:63083	BioGRID:65293	W	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:57554	ac	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:59621	aop	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:65137	aos	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:57697	arm	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:59535	ast	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:66156	ato	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:63464	bs	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:60980	cact	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:68605	ci	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:62870	cora	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:69557	csw	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:60497	da	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:60991	dac	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:59659	dpp	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:59468	ebi	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:59819	ed	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:63646	emc	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:60071	eya	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:68827	fus	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:68062	gro	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:61396	gus	BioGRID	PubMed	Two-hybrid
BioGRID:63083	BioGRID:67184	htl	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:533679	kay	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:60732	kek1	BioGRID	PubMed	Phenotypic Suppression; Reconstituted Complex
BioGRID:63083	BioGRID:69588	kn	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:65544	kni	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:59717	lilli	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:69604	net	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:57942	ovo	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:57758	phl	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:63189	px	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:69112	rg	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:63708	rho	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:78013	rl	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:63083	BioGRID:58454	sev	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:58941	sl	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:61229	spi	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:68145	spz	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:63919	sty	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:66603	svp	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:59924	tkv	BioGRID	PubMed	Phenotypic Suppression
BioGRID:63083	BioGRID:67924	veli	BioGRID	PubMed	Two-hybrid
BioGRID:63083	BioGRID:64117	vn	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:63083	BioGRID:64202	vvl	BioGRID	PubMed	Phenotypic Enhancement

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General gene information

Pathways from BioSystems

Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dorso-ventral axis formation, organism-specific biosystem (from KEGG)
Dorso-ventral axis formation, organism-specific biosystem
Dorso-ventral axis formation
Dorso-ventral axis formation, conserved biosystem (from KEGG)
Dorso-ventral axis formation, conserved biosystem
Dorso-ventral axis formation
EGFR downregulation, organism-specific biosystem (from REACTOME)
EGFR downregulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
L1CAM interactions, organism-specific biosystem (from REACTOME)
L1CAM interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAPK signaling pathway - fly, organism-specific biosystem (from KEGG)
MAPK signaling pathway - fly, organism-specific biosystem
MAPK signaling pathway - fly
MAPK signaling pathway - fly, conserved biosystem (from KEGG)
MAPK signaling pathway - fly, conserved biosystem
MAPK signaling pathway - fly
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal transduction by L1, organism-specific biosystem (from REACTOME)
Signal transduction by L1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
Signaling by EGFR in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
epidermal growth factor-activated receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
epidermal growth factor-activated receptor activity	TAS Traceable Author Statement more info	PubMed
gurken-activated receptor activity	NAS Non-traceable Author Statement more info
protein domain specific binding	IEA Inferred from Electronic Annotation more info
protein tyrosine kinase activity	NAS Non-traceable Author Statement more info
transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
Malpighian tubule morphogenesis	TAS Traceable Author Statement more info	PubMed
R7 cell differentiation	TAS Traceable Author Statement more info	PubMed
antennal development	NAS Non-traceable Author Statement more info	PubMed
anterior/posterior pattern specification	TAS Traceable Author Statement more info	PubMed
anti-apoptosis	NAS Non-traceable Author Statement more info	PubMed
behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
blastoderm segmentation	TAS Traceable Author Statement more info	PubMed
border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
border follicle cell migration	TAS Traceable Author Statement more info	PubMed
brain development	TAS Traceable Author Statement more info	PubMed
branched duct epithelial cell fate determination, open tracheal system	TAS Traceable Author Statement more info	PubMed
cell fate commitment	NAS Non-traceable Author Statement more info
cell fate determination	TAS Traceable Author Statement more info	PubMed
cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
chorion-containing eggshell pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
chorion-containing eggshell pattern formation	TAS Traceable Author Statement more info	PubMed
compound eye cone cell fate commitment	TAS Traceable Author Statement more info	PubMed
compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
compound eye morphogenesis	TAS Traceable Author Statement more info	PubMed
compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
compound eye photoreceptor cell differentiation	TAS Traceable Author Statement more info	PubMed
compound eye photoreceptor fate commitment	TAS Traceable Author Statement more info	PubMed
determination of genital disc primordium	IMP Inferred from Mutant Phenotype more info	PubMed
digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info
dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
dorsal/ventral axis specification	NAS Non-traceable Author Statement more info
dorsal/ventral pattern formation	TAS Traceable Author Statement more info	PubMed
embryonic axis specification	NAS Non-traceable Author Statement more info
embryonic pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
embryonic pattern specification	TAS Traceable Author Statement more info	PubMed
epidermal growth factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
establishment or maintenance of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
eye development	IMP Inferred from Mutant Phenotype more info	PubMed
eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
female germ-line cyst encapsulation	TAS Traceable Author Statement more info	PubMed
gastrulation	TAS Traceable Author Statement more info	PubMed
germ-band shortening	IMP Inferred from Mutant Phenotype more info	PubMed
germ-band shortening	TAS Traceable Author Statement more info	PubMed
germ-line stem cell maintenance	IGI Inferred from Genetic Interaction more info	PubMed
gonad development	IMP Inferred from Mutant Phenotype more info
gurken receptor signaling pathway	NAS Non-traceable Author Statement more info
haltere development	IMP Inferred from Mutant Phenotype more info	PubMed
heart process	IMP Inferred from Mutant Phenotype more info
imaginal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
imaginal disc development	NAS Non-traceable Author Statement more info
imaginal disc development	TAS Traceable Author Statement more info	PubMed
imaginal disc pattern formation	NAS Non-traceable Author Statement more info
imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
imaginal disc-derived wing morphogenesis	NAS Non-traceable Author Statement more info	PubMed
imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
imaginal disc-derived wing vein morphogenesis	TAS Traceable Author Statement more info	PubMed
imaginal disc-derived wing vein specification	TAS Traceable Author Statement more info	PubMed
leg disc proximal/distal pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
leg disc proximal/distal pattern formation	TAS Traceable Author Statement more info	PubMed
maintenance of epithelial integrity, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
male germ-line cyst encapsulation	TAS Traceable Author Statement more info	PubMed
maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded	IMP Inferred from Mutant Phenotype more info	PubMed
morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
morphogenesis of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
muscle attachment	TAS Traceable Author Statement more info	PubMed
muscle cell fate specification	TAS Traceable Author Statement more info	PubMed
negative regulation of S phase of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of compound eye retinal cell programmed cell death	TAS Traceable Author Statement more info	PubMed
neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
notum cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
notum development	IMP Inferred from Mutant Phenotype more info	PubMed
oenocyte differentiation	TAS Traceable Author Statement more info	PubMed
ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
oocyte anterior/posterior axis specification	NAS Non-traceable Author Statement more info	PubMed
oocyte axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
oocyte dorsal/ventral axis specification	NAS Non-traceable Author Statement more info	PubMed
oogenesis	NAS Non-traceable Author Statement more info
open tracheal system development	TAS Traceable Author Statement more info	PubMed
peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
progression of morphogenetic furrow involved in compound eye morphogenesis	TAS Traceable Author Statement more info	PubMed
protein phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	NAS Non-traceable Author Statement more info	PubMed
regulation of R8 cell spacing in compound eye	NAS Non-traceable Author Statement more info	PubMed
regulation of R8 cell spacing in compound eye	TAS Traceable Author Statement more info	PubMed
regulation of hemocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
salivary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
second mitotic wave involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
second mitotic wave involved in compound eye morphogenesis	TAS Traceable Author Statement more info	PubMed
segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
spiracle morphogenesis, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
stomatogastric nervous system development	TAS Traceable Author Statement more info	PubMed
tracheal pit formation in open tracheal system	TAS Traceable Author Statement more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
wing and notum subfield formation	IMP Inferred from Mutant Phenotype more info	PubMed
wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
wing disc proximal/distal pattern formation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
integral to plasma membrane	NAS Non-traceable Author Statement more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info	PubMed

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General protein information

Preferred Names: CG10079 gene product from transcript CG10079-RA

Names: CG10079-PA; CG10079-PB; DER-Ellipse; EGF-receptor; EGFR; Egf receptor; Egfr-PA; Egfr-PB; drosophila epidermal growth factor receptor homologue; ellipse; ellipse torpedo; epidermal growth factor receptor; faint little ball; morphological defects 1; torpedo; torpedo/DER

NP_476758.1

EC 2.7.10.-

NP_476759.1

EC 2.7.10.-

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

17410510..17446932

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057410.3 → NP_476758.1 epidermal growth factor receptor, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q8MLW0

Related

FBpp0071570, FBtr0071653

Conserved Domains (6) summary

cd00064
Location:574 – 612
Blast Score: 109

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05057
Location:881 – 1159
Blast Score: 1406

PTKc_EGFR_like; Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases

cl00066
Location:735 – 785
Blast Score: 114

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:204 – 354
Blast Score: 379

Furin-like; Furin-like cysteine rich region

pfam01030
Location:370 – 498
Blast Score: 286

Recep_L_domain; Receptor L domain

pfam07714
Location:889 – 1141
Blast Score: 927

Pkinase_Tyr; Protein tyrosine kinase
NM_057411.3 → NP_476759.1 epidermal growth factor receptor, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P04412

Related

FBpp0071571, FBtr0071654

Conserved Domains (6) summary

cd00064
Location:623 – 661
Blast Score: 109

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05057
Location:930 – 1208
Blast Score: 1407

PTKc_EGFR_like; Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases

cl00066
Location:784 – 834
Blast Score: 114

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:253 – 403
Blast Score: 378

Furin-like; Furin-like cysteine rich region

pfam01030
Location:419 – 547
Blast Score: 287

Recep_L_domain; Receptor L domain

pfam07714
Location:938 – 1190
Blast Score: 927

Pkinase_Tyr; Protein tyrosine kinase