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plcg1 phospholipase C, gamma 1 [ Danio rerio (zebrafish) ]

Gene ID: 373867, updated on 27-Mar-2024

Summary

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Official Symbol
plcg1provided by ZNC
Official Full Name
phospholipase C, gamma 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030421-3
See related
Ensembl:ENSDARG00000038442 AllianceGenome:ZFIN:ZDB-GENE-030421-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj46f04; wu:fj46f04; wu:fj57a05
Summary
Predicted to enable phosphatidylinositol phospholipase C activity. Acts upstream of or within several processes, including blood vessel morphogenesis; fin regeneration; and hemopoiesis. Is expressed in brain; intermediate cell mass of mesoderm; ovary; pericardial region; and vasculature. Orthologous to human PLCG1 (phospholipase C gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
31
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (2790177..2870869)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (2848501..2927173)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene zgc:114123 Neighboring gene DNA topoisomerase Ib Neighboring gene zinc fingers and homeoboxes 3b Neighboring gene RAB5 interacting factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The role of phospholipase C gamma 1 in primitive hematopoiesis during zebrafish development. Ma AC, et al. Exp Hematol, 2007 Mar. PMID 17309817
  2. miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo. Pedrioli DM, et al. Mol Cell Biol, 2010 Jul. PMID 20479124, Free PMC Article
  3. Vasohibin 1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk. de Oliveira MB, et al. Development, 2021 Feb 19. PMID 33547133, Free PMC Article
  4. An investigation into the role of prostaglandins in zebrafish oocyte maturation and ovulation. Lister AL, et al. Gen Comp Endocrinol, 2008 Oct. PMID 18722378
  5. The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk. Mauri C, et al. Angiogenesis, 2021 May. PMID 33677657, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish
    Title: Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish.
  2. genetic analyses suggest that Vegf/Plcg1 signaling acts at multiple time points and in different signaling contexts to mediate distinct aspects of artery development
    Title: A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development.
  3. muscle of the heart uses the VEGF-PLCgamma1 cascade to control the strength of the heart beat
    Title: VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of epithelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of angioblast cell migration involved in selective angioblast sprouting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Names
dead beat
ded
NP_919388.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194407.1 → NP_919388.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

    See identical proteins and their annotated locations for NP_919388.1

    Status: PROVISIONAL

    Source sequence(s)
    AY163168
    UniProtKB/TrEMBL
    Q804J6
    Related
    ENSDARP00000120537.1, ENSDART00000135781.2
    Conserved Domains (11) summary
    smart00149
    Location:949 → 1064
    PLCYc; Phospholipase C, catalytic domain (part); domain Y
    cd00275
    Location:1082 → 1206
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:314 → 472
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:658 → 760
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:540 → 644
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11970
    Location:786 → 845
    SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1
    cd13234
    Location:857 → 928
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:29 → 151
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    pfam00169
    Location:865 → 924
    PH; PH domain
    pfam09279
    Location:242 → 306
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl17171
    Location:484 → 521
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    2790177..2870869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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