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    insc inscuteable [ Drosophila melanogaster ]

    Gene ID: 37355, updated on 10-May-2012
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    Summary

    Official Symbol
    inscprovided by Flybase
    Official Full Name
    inscuteableprovided by Flybase
    Primary source
    FLYBASE:FBgn0011674
    Locus tag
    Dmel_CG11312
    Gene type
    protein coding
    RNA name
    inscuteable
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    25/17; CG11312; Dmel\CG11312; fam; Ins; Insc; l(2)05475; l(2)k12405; nem
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    Genomic context

    Location :
    57B3-57B3
    Sequence :
    Chromosome: 2R; NT_033778.3 (16708771..16723569, complement)
    See insc in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG15226 gene product from transcript CG15226-RA Neighboring gene CG15225 gene product from transcript CG15225-RA Neighboring gene skittles Neighboring gene CG17999 gene product from transcript CG17999-RA Neighboring gene CG9993 gene product from transcript CG9993-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions. Culurgioni S, et al. Proc Natl Acad Sci U S A, 2011 Dec 27. PMID 22171003.
    2. The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb. Zhu Z, et al. Mech Dev, 2011 Sep-Dec. PMID 21996673.
    3. Robust spindle alignment in Drosophila neuroblasts by ultrasensitive activation of pins. Smith NR, et al. Mol Cell, 2011 Aug 19. PMID 21855794.
    4. Multipotent neural stem cells generate glial cells of the central complex through transit amplifying intermediate progenitors in Drosophila brain development. Viktorin G, et al. Dev Biol, 2011 Aug 15. PMID 21708145.
    5. On the roles of Notch, Delta, kuzbanian, and inscuteable during the development of Drosophila embryonic neuroblast lineages. Udolph G, et al. Dev Biol, 2009 Dec 15. PMID 19782677.

    See all (185) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb.
      Title: The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb.
    2. Inscuteable and NuMA [Mud] proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions.
      Title: Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions.
    3. three neuroblast lineages (NB1-1, NB4-2, and NB7-1) require insc function for sibling cell fate specification in cells born from early ganglion mother cells (GMCs) whereas insc is not required in cells born from later GMCs of the same lineages
      Title: On the roles of Notch, Delta, kuzbanian, and inscuteable during the development of Drosophila embryonic neuroblast lineages.
    4. we show that Inscuteable, a multiadapter protein required for asymmetric cell division, participates in the formation of specific heart cells to distinguish between a myogenic (cardiomyoblast) and a nonmyogenic (pericardial cell) fate.
      Title: Cell fate decisions in the Drosophila dorsal vessel depend on the multiadapter protein inscuteable.
    5. Insc is required for accurate control of metaphase spindle length, division orientation, and asymmetric cell division.
      Title: Inscuteable mRNA localization is dynein-dependent and regulates apicobasal polarity and spindle length in Drosophila neuroblasts.
    6. Results show that many identified neuroblast lineages do not require inscuteable for normal morphological development.
      Title: Inscuteable-independent apicobasally oriented asymmetric divisions in the Drosophila embryonic CNS.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:63001 BioGRID:64214 G-ialpha65A    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:63001 BioGRID:67421 H    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:63001 BioGRID:57823 N    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:63001 BioGRID:60430 Pen    BioGRID  PubMed Two-hybrid 
    BioGRID:63001 BioGRID:65180 TSG101    BioGRID  PubMed Two-hybrid 
    BioGRID:63001 BioGRID:59832 Traf4    BioGRID  PubMed Two-hybrid 
    BioGRID:63001 BioGRID:66645 Vha55    BioGRID  PubMed Two-hybrid 
    BioGRID:63001 BioGRID:64231 corn    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:63001 BioGRID:72799 raps    BioGRID  PubMed Phenotypic Enhancement 
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    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    cytoskeletal adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cytoskeletal adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    cytoskeletal adaptor activity NAS
    Non-traceable Author Statement
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    RNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    apical protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    apical protein localization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    asymmetric cell division TAS
    Traceable Author Statement
    more info
    		 PubMed 
    asymmetric neuroblast division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    asymmetric neuroblast division TAS
    Traceable Author Statement
    more info
    		 PubMed 
    asymmetric protein localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    asymmetric protein localization involved in cell fate determination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    asymmetric protein localization involved in cell fate determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    basal protein localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		  
    establishment of mitotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    establishment of mitotic spindle localization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    establishment of mitotic spindle localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    neuroblast fate determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein localization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    sensory organ development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apical cortex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    apical part of cell NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG11312 gene product from transcript CG11312-RA
    Names
    CG11312-PA
    fata morgana
    insc-PA
    inscrutable
    inscutable
    inscuteable
    not enough muscles
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      16708771..16723569, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057676.3 → NP_477024.1  inscuteable [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2R4
      Related
      FBpp0071490, FBtr0071562
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAF46626.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2R4.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content