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    CD82 CD82 molecule [ Homo sapiens ]

    Gene ID: 3732, updated on 13-May-2012
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    Summary

    Official Symbol
    CD82provided by HGNC
    Official Full Name
    CD82 moleculeprovided by HGNC
    Primary source
    HGNC:6210
    See related
    Ensembl:ENSG00000085117; HPRD:09004; MIM:600623; Vega:OTTHUMG00000166472
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27
    Summary
    This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    11p11.2
    Sequence :
    Chromosome: 11; NC_000011.9 (44587141..44641339)
    See CD82 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene ALX homeobox 4 Neighboring gene 60S ribosomal protein L7a-like Neighboring gene ribosomal protein L34 pseudogene 22 Neighboring gene tetraspanin 18 Neighboring gene tumor protein p53 inducible protein 11

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. CD82 expression alters with human endometrial cycles and affects the uterine endometrial receptivity in vitro. Wei X, et al. Exp Biol Med (Maywood), 2012 Mar 1. PMID 22393164.
    2. [Expression of CD82/KAI1 and HIF-1α in non-small cell lung cancer and their relationship to vasculogenic mimicry]. Wu S, et al. Zhongguo Fei Ai Za Zhi, 2011 Dec. PMID 22152691.
    3. Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in primary oral squamous cell carcinoma and corresponding metastases in cervical lymph nodes: association with the metastasis suppressor CD82. Kawasaki G, et al. Anticancer Res, 2011 Oct. PMID 21965773.
    4. [Correlation of CD82 and hTERT expressions and HPV infection with penile cancer]. Zhai JP, et al. Zhonghua Nan Ke Xue, 2011 Sep. PMID 21961244.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (108) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. CD82 expression affects endometrial receptivity of the uterine epithelial cells in vitro
      Title: CD82 expression alters with human endometrial cycles and affects the uterine endometrial receptivity in vitro.
    2. The pathological stage of penile carcinoma, but not lymph node metastasis, was positively correlated with the expression of CD82.
      Title: [Correlation of CD82 and hTERT expressions and HPV infection with penile cancer].
    3. Angiogenesis and the expressions of CD82 and HIF-1alpha are related to differentiation, lymph node metastasis and clinical staging in non-small cell lung cancer.
      Title: [Expression of CD82/KAI1 and HIF-1α in non-small cell lung cancer and their relationship to vasculogenic mimicry].
    4. Study demonstrated that the abnormal lower CD82 expression in ESCs induced by TCDD and estrogen may be an important molecular basis of endometriosis pathogenesis through enhancing the CCL2 secretion and CCR2 expression and the invasion of ESCs.
      Title: CD82 gene suppression in endometrial stromal cells leads to increase of the cell invasiveness in the endometriotic milieu.
    5. Dissecting the diverse functions of the metastasis suppressor CD82/KAI1.
      Title: Dissecting the diverse functions of the metastasis suppressor CD82/KAI1.
    6. This study investigated the expression of TS and DPD in cervical lymph node metastases and its relationship with primary oral squamous cell carcinoma, as well as the interaction between these enzymes and Kangai 1(KAI1/CD82).
      Title: Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in primary oral squamous cell carcinoma and corresponding metastases in cervical lymph nodes: association with the metastasis suppressor CD82.
    7. Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and beta1 integrin activation.
      Title: Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and β1 integrin activation.
    8. decreased levels of CD82 protein were strikingly associated with the tumor status and the distant metastasis.
      Title: Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma.
    9. demonstrated a regulatory role for KAI1 in sphingosine kinase activation, which leads to decreased invasive ability in disease progression of human pancreatic cancer
      Title: KAI1 inhibits HGF-induced invasion of pancreatic cancer by sphingosine kinase activity.
    10. KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer.
      Title: KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer.
    Submit: New GeneRIF Correction See all (78)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Prostate cancer, susceptibility to

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag proteins co-localize with tetraspanins CD9, CD81, and CD82 in CD63-enriched microdomains PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000011.8 NP_005169.1 BCL3    BIND  PubMed BCL3 interacts with the CD82 (KAI1) promoter. 
    NC_000011.8 NP_001895.1 CTNNB1    BIND  PubMed CTNNB1 (beta-catenin) interacts with the CD82 (KAI1) promoter. 
    NC_000011.8 KAT5    BIND  PubMed HTATIP (Tip60) interacts with the CD82 (KAI1) promoter. 
    NC_000011.8 XP_042066.8 MAP3K1    BIND  PubMed MAP3K1 (MEKK1) interacts with the CD82 (KAI1) promoter. 
    NC_000011.8 NP_006302.2 NCOR1    BIND  PubMed NCOR1 (N-CoR) interacts with the CD82 (KAI1) promoter. 
    NC_000011.8 NP_003989.2 NFKB1    BIND  PubMed NFKB1 (p50) interacts with the CD82 (KAI1) promoter. 
    NC_000011.8 NP_000928.1 POLR2A    BIND  PubMed POLR2A (pol II) interacts with the CD82 (KAI1) promoter. 
    NC_000011.8 NP_003698.1 RUVBL1    BIND  PubMed RUVBL1 (pontin) interacts with the CD82 (KAI1) promoter. 
    NC_000011.8 NP_006657.1 RUVBL2    BIND  PubMed RUVBL2 (reptin) interacts with the CD82 (KAI1) promoter. 
    NC_000011.8 TAB2    BIND  PubMed An unspecified isoform of MAP3K7IP2 (TAB2) interacts with the CD82 (KAI1) promoter. 
    P27701 P27824 CANX    HPRD  PubMed  
    P27701 P15391 CD19    HPRD  PubMed  
    P27701 P01730 CD4    HPRD  PubMed  
    P27701 P08962 CD63    HPRD  PubMed  
    P27701 P00533 EGFR    HPRD  PubMed  
    P27701 P04626 ERBB2    HPRD  PubMed  
    P27701 P21860 ERBB3    HPRD  PubMed  
    P27701 Q99075 HBEGF    HPRD  PubMed  
    P27701 P28067 HLA-DMA    HPRD  PubMed  
    P27701 P28068 HLA-DMB    HPRD  PubMed  
    P27701 P01903 HLA-DRA    HPRD  PubMed  
    P27701 Q969P0 IGSF8    HPRD  PubMed  
    P27701 P26006 ITGA3    HPRD  PubMed  
    P27701 P13612 ITGA4    HPRD  PubMed  
    P27701 P23229 ITGA6    HPRD  PubMed  
    P27701 P05556 ITGB1    HPRD  PubMed  
    P27701 P05107 ITGB2    HPRD  PubMed  
    P27701 Q07954 LRP1    HPRD  PubMed  
    P27701 Q99567 NUP88    HPRD  PubMed  
    P27701 Q9P2B2 PTGFRN    HPRD  PubMed  
    P27701 Q8TAA9 VANGL1    HPRD  PubMed  
    BioGRID:109935 BioGRID:107415 CD151    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:107368 CD19    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:110346 CD46    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:107405 CD63    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:107366 CD9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:108376 ERBB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:108377 ERBB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:108172 HBEGF    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:109354 HLA-DMB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:109357 HLA-DOB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:109367 HLA-DRA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:125011 IGSF8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:109889 ITGAL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:111710 PTGFRN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109935 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CD82 antigen
    Names
    CD82 antigen
    tspan-27
    C33 antigen
    tetraspanin-27
    inducible membrane protein R2
    metastasis suppressor Kangai-1
    kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023234.1 RefSeqGene

      Range
      5001..59199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024844.1 → NP_001020015.1  CD82 antigen isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. The encoded isoform (2) thus lacks a segment in the middle region, as compared to isoform 1.
      Source sequence(s)
      AC010768, AY303776, CB127804, U20770
      Consensus CDS
      CCDS31469.1
      UniProtKB/TrEMBL
      E9PC70
      UniProtKB/Swiss-Prot
      P27701
      UniProtKB/TrEMBL
      Q7Z5N2
      Related
      ENSP00000339686, OTTHUMP00000232951, ENST00000342935, OTTHUMT00000389887
      Conserved Domains (2) summary
      cd03160
      Location:86 – 202
      Blast Score: 376
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 – 231
      Blast Score: 259
      Tetraspannin; Tetraspanin family

    2. NM_002231.3 → NP_002222.1  CD82 antigen isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC010768, CB127804, U20770
      Consensus CDS
      CCDS7909.1
      UniProtKB/Swiss-Prot
      P27701
      Related
      ENSP00000227155, OTTHUMP00000232950, ENST00000227155, OTTHUMT00000389886
      Conserved Domains (2) summary
      cd03160
      Location:106 – 227
      Blast Score: 397
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 – 256
      Blast Score: 297
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      44587141..44641339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      44296423..44350592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC010768.10 (16150..70349) None
    genomic CH471064.2 EAW68063.1
      EAW68064.1
      EAW68065.1
    genomic JA738773.1 CCF77039.1
    genomic JA738775.1 CCF77040.1
    genomic U67266.1 None
    genomic U67274.1 AAC51205.1
    mRNA AK225410.1 None
    mRNA AK225708.1 None
    mRNA AK312677.1 BAG35558.1
    mRNA AY303776.1 AAP76181.1
    mRNA BC000726.2 AAH00726.1
    mRNA BC001821.2 AAH01821.1
    mRNA BT019761.1 AAV38566.1
    mRNA BT019762.1 AAV38567.1
    mRNA CB127804.1 None
    mRNA CR407650.1 CAG28578.1
    mRNA CR542255.1 CAG47051.1
    mRNA S48196.1 AAB23825.1
    mRNA U20770.1 AAC50133.1
    other-genetic DQ892302.2 ABM83228.1
    other-genetic DQ895501.2 ABM86427.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27701.1 GenPept UniProtKB/Swiss-Prot:P27701
    Q6LET0 GenPept UniProtKB/TrEMBL:Q6LET0
    Q7Z5N2 GenPept UniProtKB/TrEMBL:Q7Z5N2
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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